Nirmatrelvir Related Compounds & Impurities

Nirmatrelvir is a SARS-CoV-2 3CL protease inhibitor, the antiviral component of Paxlovid used for COVID-19 treatment.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Nirmatrelvir reference standards, pharmacopeial and non-pharmacopeial Nirmatrelvir impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Nirmatrelvir-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Nirmatrelvir
Nirmatrelvir
  • CAT. No.N920000
  • CAS. No.2628280-40-8
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Instock
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Nirmatrelvir Impurity 1
Nirmatrelvir Impurity 1
  • CAT. No.N920002
  • CAS. No.NA
  • Mol. F.C23H33F3N4O6
  • Mol. W.518.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir R-Isomer
Nirmatrelvir R-Isomer
  • CAT. No.N920003
  • CAS. No.2755812-41-8
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Instock
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N-((S)-1-((1R,2S,5S)-2-cyano-6,6- dimethyl-3-azabicyclo[3.1.0]hexan-3-yl) -3,3-dimethyl-1-oxobutan-2-yl)- 2,2,2-trifluoroacetamide
N-((S)-1-((1R,2S,5S)-2-cyano-6,6- dimethyl-3-azabicyclo[3.1.0]hexan-3-yl) -3,3-dimethyl-1-oxobutan-2-yl)- 2,2,2-trifluoroacetamide
  • CAT. No.N920004
  • CAS. No.NA
  • Mol. F.C16H22F3N3O2
  • Mol. W.345.36 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 4
Nirmatrelvir Impurity 4
  • CAT. No.N920005
  • CAS. No.NA
  • Mol. F.C23H33ClF3N5O4
  • Mol. W.535.99 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 5
Nirmatrelvir Impurity 5
  • CAT. No.N920006
  • CAS. No.NA
  • Mol. F.C26H39F3N4O6
  • Mol. W.560.61 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 7
Nirmatrelvir Impurity 7
  • CAT. No.N920007
  • CAS. No.NA
  • Mol. F.C24H35F3N4O6
  • Mol. W.532.55 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 36
Nirmatrelvir Impurity 36
  • CAT. No.N920008
  • CAS. No.2883654-28-0
  • Mol. F.C21H33N5O3
  • Mol. W.403.52 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanenitrile Hydrochloride
(S)-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanenitrile Hydrochloride
  • CAT. No.N920009
  • CAS. No.2755950-35-5
  • Mol. F.C7H11N3O.HCl
  • Mol. W.189.64 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity B
Nirmatrelvir Impurity B
  • CAT. No.N920010
  • CAS. No.2755812-81-6
  • Mol. F.23H34F3N5O5
  • Mol. W.517.55 g/mol
  • Stock Status:Instock
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(2S)-2-Amino-3-[(3S)-2-oxopyrrolidin-3-yl]propanamide hydrochloride
(2S)-2-Amino-3-[(3S)-2-oxopyrrolidin-3-yl]propanamide hydrochloride
  • CAT. No.N920011
  • CAS. No.2628280-48-6
  • Mol. F.C7H14ClN3O2
  • Mol. W.207.66 g/mol
  • Stock Status:Custom Synthesis
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(S)-methyl-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate Hydrochloride
(S)-methyl-2-amino-3-((S)-2-oxopyrrolidin-3-yl)propanoate Hydrochloride
  • CAT. No.N920012
  • CAS. No.1429218-41-6
  • Mol. F.C8H15ClN2O3
  • Mol. W.222.67 g/mol
  • Stock Status:Custom Synthesis
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(R)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)propanamide Hydrochloride
(R)-2-Amino-3-((S)-2-oxopyrrolidin-3-yl)propanamide Hydrochloride
  • CAT. No.N920013
  • CAS. No.NA
  • Mol. F.C7H14ClN3O2
  • Mol. W.207.66 g/mol
  • Stock Status:Custom Synthesis
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Methyl(1S,2R,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
Methyl(1S,2R,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
  • CAT. No.N920014
  • CAS. No.943516-62-9
  • Mol. F.C9H15NO2
  • Mol. W.169.22 g/mol
  • Stock Status:Custom Synthesis
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(S)-2-Amino-3-((R)-2-oxopyrrolidin-3-yl)propanamide Hydrochloride
(S)-2-Amino-3-((R)-2-oxopyrrolidin-3-yl)propanamide Hydrochloride
  • CAT. No.N920015
  • CAS. No.NA
  • Mol. F.C7H14ClN3O2
  • Mol. W.207.66 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 39
Nirmatrelvir Impurity 39
  • CAT. No.N920016
  • CAS. No.394735-37-6
  • Mol. F.C19H32N2O5
  • Mol. W.368.47 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 34
Nirmatrelvir Impurity 34
  • CAT. No.N920017
  • CAS. No.2755812-45-2
  • Mol. F.C16H23F3N2O4
  • Mol. W.364.40 g/mol
  • Stock Status:Custom Synthesis
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(R)-2-amino-3-((R)-2-oxopyrrolidin-3-yl)propanamide hydrochloride
(R)-2-amino-3-((R)-2-oxopyrrolidin-3-yl)propanamide hydrochloride
  • CAT. No.N920018
  • CAS. No.NA
  • Mol. F.C7H14ClN3O2
  • Mol. W.207.66 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity D
Nirmatrelvir Impurity D
  • CAT. No.N920019
  • CAS. No.565456-77-1
  • Mol. F.C9H16ClNO2
  • Mol. W.205.68 g/mol
  • Stock Status:Instock
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Nirmatrelvir Impurity 41
Nirmatrelvir Impurity 41
  • CAT. No.N920020
  • CAS. No.NA
  • Mol. F.C7H12NO3S.Na
  • Mol. W.213.20 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 43
Nirmatrelvir Impurity 43
  • CAT. No.N920021
  • CAS. No.NA
  • Mol. F.C8H12N2
  • Mol. W.136.19 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 42
Nirmatrelvir Impurity 42
  • CAT. No.N920022
  • CAS. No.2742706-71-2
  • Mol. F.C17H25F3N2O4
  • Mol. W.378.39 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 44
Nirmatrelvir Impurity 44
  • CAT. No.N920023
  • CAS. No.124655-17-0
  • Mol. F.C11H21NO4
  • Mol. W.231.29 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 40
Nirmatrelvir Impurity 40
  • CAT. No.N920024
  • CAS. No.1932411-98-7
  • Mol. F.C9H15NO2
  • Mol. W.169.22 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 45
Nirmatrelvir Impurity 45
  • CAT. No.N920025
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 30
Nirmatrelvir Impurity 30
  • CAT. No.N920026
  • CAS. No.1037559-82-2
  • Mol. F.C8H12N2
  • Mol. W.136.19 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 2
Nirmatrelvir Impurity 2
  • CAT. No.N920027
  • CAS. No.NA
  • Mol. F.C25H31F6N5O5
  • Mol. W.595.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 6
Nirmatrelvir Impurity 6
  • CAT. No.N920028
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 8
Nirmatrelvir Impurity 8
  • CAT. No.N920029
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 9
Nirmatrelvir Impurity 9
  • CAT. No.N920030
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 10
Nirmatrelvir Impurity 10
  • CAT. No.N920031
  • CAS. No.NA
  • Mol. F.C23H33ClF3N5O4
  • Mol. W.535.99 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 11
Nirmatrelvir Impurity 11
  • CAT. No.N920032
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 12
Nirmatrelvir Impurity 12
  • CAT. No.N920033
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 3
Nirmatrelvir Impurity 3
  • CAT. No.N920034
  • CAS. No.NA
  • Mol. F.C23H32F3N5O4
  • Mol. W.499.53 g/mol
  • Stock Status:Custom Synthesis
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Nirmatrelvir Impurity 13
Nirmatrelvir Impurity 13
  • CAT. No.N920036
  • CAS. No.NA
  • Mol. F.C21H33N5O3
  • Mol. W.403.52 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Nirmatrelvir D9
Nirmatrelvir D9
  • CAT. No.N920001
  • CAS. No.2861202-76-6
  • Mol. F.C23H23D9F3N5O4
  • Mol. W.508.58 g/mol
  • Stock Status:Custom Synthesis
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