Niraparib Related Compounds & Impurities

Niraparib is a PARP inhibitor used for maintenance treatment of recurrent epithelial ovarian cancer regardless of BRCA status.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Niraparib reference standards, pharmacopeial and non-pharmacopeial Niraparib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Niraparib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Niraparib
Niraparib
  • CAT. No.N700000
  • CAS. No.1038915-60-4
  • Mol. F.C19H20N4O
  • Mol. W.320.39 g/mol
  • Stock Status:Custom Synthesis
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Niraparib tosylate monohydrate
Niraparib tosylate monohydrate
  • CAT. No.N700000A
  • CAS. No.1613220-15-7
  • Mol. F.C19H20N4O.C7H8O3S.H2O
  • Mol. W.510.61 g/mol
  • Stock Status:Instock
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Niraparib Tosylate
Niraparib Tosylate
  • CAT. No.N700000B
  • CAS. No.1038915-73-9
  • Mol. F.C19H20N4O.C7H8O3S
  • Mol. W.492.59 g/mol
  • Stock Status:Custom Synthesis
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ent-Niraparib
ent-Niraparib
  • CAT. No.N700001
  • CAS. No.1038915-58-0
  • Mol. F.C19H20N4O
  • Mol. W.320.39 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Niraparib
N-Nitroso Niraparib
  • CAT. No.N700005
  • CAS. No.NA
  • Mol. F.C19H19N5O2
  • Mol. W.349.39 g/mol
  • Stock Status:Instock
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Niraparib Impurity 5
Niraparib Impurity 5
  • CAT. No.N700006
  • CAS. No.1263284-59-8
  • Mol. F.C16H24N2O2
  • Mol. W.276.38 g/mol
  • Stock Status:Custom Synthesis
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tert-butyl(R)-3-(4-(7-carbamoyl-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
tert-butyl(R)-3-(4-(7-carbamoyl-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
  • CAT. No.N700007
  • CAS. No.NA
  • Mol. F.C24H28N4O3
  • Mol. W.420.50 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 1
Niraparib Impurity 1
  • CAT. No.N700008
  • CAS. No.1038916-11-8
  • Mol. F.C24H28N4O3
  • Mol. W.420.50 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 53
Niraparib Impurity 53
  • CAT. No.N700009
  • CAS. No.1038916-08-3
  • Mol. F.C24H27N3O4
  • Mol. W.421.49 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 23
Niraparib Impurity 23
  • CAT. No.N700010
  • CAS. No.NA
  • Mol. F.C24H30N4O5
  • Mol. W.454.52 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 24
Niraparib Impurity 24
  • CAT. No.N700011
  • CAS. No.NA
  • Mol. F.C24H30N4O3
  • Mol. W.422.52 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 30
Niraparib Impurity 30
  • CAT. No.N700012
  • CAS. No.NA
  • Mol. F.C24H29N3O6
  • Mol. W.455.50 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 31
Niraparib Impurity 31
  • CAT. No.N700013
  • CAS. No.NA
  • Mol. F.C24H31N3O4
  • Mol. W.425.52 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 32
Niraparib Impurity 32
  • CAT. No.N700014
  • CAS. No.NA
  • Mol. F.C48H60N8O6
  • Mol. W.845.04 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 33
Niraparib Impurity 33
  • CAT. No.N700015
  • CAS. No.NA
  • Mol. F.C48H62N8O6
  • Mol. W.847.06 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 22
Niraparib Impurity 22
  • CAT. No.N700016
  • CAS. No.NA
  • Mol. F.C24H32N4O3
  • Mol. W.424.54 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 25
Niraparib Impurity 25
  • CAT. No.N700017
  • CAS. No.NA
  • Mol. F.C24H32N4O4
  • Mol. W.440.54 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 26
Niraparib Impurity 26
  • CAT. No.N700018
  • CAS. No.NA
  • Mol. F.C40H53N5O5
  • Mol. W.683.88 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 27
Niraparib Impurity 27
  • CAT. No.N700019
  • CAS. No.1476776-81-4
  • Mol. F.C24H26N4O2
  • Mol. W.402.49 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 28
Niraparib Impurity 28
  • CAT. No.N700020
  • CAS. No.NA
  • Mol. F.C24H30N4O2
  • Mol. W.406.52 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 29
Niraparib Impurity 29
  • CAT. No.N700021
  • CAS. No.NA
  • Mol. F.C24H28N4O3
  • Mol. W.420.50 g/mol
  • Stock Status:Custom Synthesis
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(S)-tert-butyl3-(4-((2-((4-((R)-1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-3-cyanobenzyl)amino)phenyl)piperidine-1-carboxylate
(S)-tert-butyl3-(4-((2-((4-((R)-1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-3-cyanobenzyl)amino)phenyl)piperidine-1-carboxylate
  • CAT. No.N700022
  • CAS. No.NA
  • Mol. F.C40H51N5O4
  • Mol. W.665.86 g/mol
  • Stock Status:Custom Synthesis
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Tert-butyl(S)-3-(4-((2,3-bis(3-cyano-2-nitrophenyl)allyl)amino)phenyl)piperidine-1-carboxylate
Tert-butyl(S)-3-(4-((2,3-bis(3-cyano-2-nitrophenyl)allyl)amino)phenyl)piperidine-1-carboxylate
  • CAT. No.N700023
  • CAS. No.NA
  • Mol. F.C33H32N6O6
  • Mol. W.608.64 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 37
Niraparib Impurity 37
  • CAT. No.N700024
  • CAS. No.NA
  • Mol. F.C24H28N4O4
  • Mol. W.436.50 g/mol
  • Stock Status:Custom Synthesis
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(R)-2-nitro-3-(((4-(piperidin-3-yl)phenyl)amino)methyl)benzonitrile
(R)-2-nitro-3-(((4-(piperidin-3-yl)phenyl)amino)methyl)benzonitrile
  • CAT. No.N700025
  • CAS. No.NA
  • Mol. F.C19H20N4O2
  • Mol. W.336.39 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 39
Niraparib Impurity 39
  • CAT. No.N700026
  • CAS. No.NA
  • Mol. F.C32H32N6O6
  • Mol. W.596.63 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 40
Niraparib Impurity 40
  • CAT. No.N700027
  • CAS. No.NA
  • Mol. F.C24H28N4O5
  • Mol. W.452.50 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 41
Niraparib Impurity 41
  • CAT. No.N700028
  • CAS. No.NA
  • Mol. F.C10H12N2O
  • Mol. W.176.22 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 42
Niraparib Impurity 42
  • CAT. No.N700029
  • CAS. No.NA
  • Mol. F.C26H34N4O2
  • Mol. W.434.57 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 43
Niraparib Impurity 43
  • CAT. No.N700030
  • CAS. No.NA
  • Mol. F.C24H26N4O5
  • Mol. W.450.49 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 45
Niraparib Impurity 45
  • CAT. No.N700031
  • CAS. No.NA
  • Mol. F.C22H25N5O3
  • Mol. W.407.47 g/mol
  • Stock Status:Custom Synthesis
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(S)-tert-butyl3-(4-((2-((4-((R)-1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-3-cyanobenzylidene)amino)phenyl)piperidine-1-carboxylate
(S)-tert-butyl3-(4-((2-((4-((R)-1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-3-cyanobenzylidene)amino)phenyl)piperidine-1-carboxylate
  • CAT. No.N700032
  • CAS. No.NA
  • Mol. F.C40H49N5O4
  • Mol. W.663.85 g/mol
  • Stock Status:Custom Synthesis
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Tert-butyl(S)-3-(4-((2,3-bis(3-cyano-2-nitrophenyl)allylidene)amino)phenyl)piperidine-1-carboxylate
Tert-butyl(S)-3-(4-((2,3-bis(3-cyano-2-nitrophenyl)allylidene)amino)phenyl)piperidine-1-carboxylate
  • CAT. No.N700033
  • CAS. No.NA
  • Mol. F.C33H30N6O6
  • Mol. W.606.63 g/mol
  • Stock Status:Custom Synthesis
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(R)-tert-butyl 3-(4-((3-cyano-2-nitrobenzylidene)amino)phenyl)piperidine-1-carboxylate
(R)-tert-butyl 3-(4-((3-cyano-2-nitrobenzylidene)amino)phenyl)piperidine-1-carboxylate
  • CAT. No.N700034
  • CAS. No.NA
  • Mol. F.C24H26N4O4
  • Mol. W.434.49 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 49
Niraparib Impurity 49
  • CAT. No.N700035
  • CAS. No.NA
  • Mol. F.C25H29N3O3
  • Mol. W.419.52 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 50
Niraparib Impurity 50
  • CAT. No.N700036
  • CAS. No.NA
  • Mol. F.C24H27N3O3
  • Mol. W.405.49 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 51
Niraparib Impurity 51
  • CAT. No.N700037
  • CAS. No.NA
  • Mol. F.C19H24N4O
  • Mol. W.324.42 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 52
Niraparib Impurity 52
  • CAT. No.N700038
  • CAS. No.NA
  • Mol. F.C19H20N4O2
  • Mol. W.336.39 g/mol
  • Stock Status:Custom Synthesis
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3-Methyl-2-nitrobenzoic acid
3-Methyl-2-nitrobenzoic acid
  • CAT. No.N700039
  • CAS. No.5437-38-7
  • Mol. F.C8H7NO4
  • Mol. W.181.15 g/mol
  • Stock Status:Instock
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Niraparib Impurity 62
Niraparib Impurity 62
  • CAT. No.N700040
  • CAS. No.93247-79-1
  • Mol. F.C12H14N2O4
  • Mol. W.250.25 g/mol
  • Stock Status:Instock
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Niraparib Impurity 63
Niraparib Impurity 63
  • CAT. No.N700041
  • CAS. No.887589-62-0
  • Mol. F.C16H24N2O2
  • Mol. W.276.37 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 64
Niraparib Impurity 64
  • CAT. No.N700042
  • CAS. No.NA
  • Mol. F.C11H14BrN
  • Mol. W.240.14 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity E
Niraparib Impurity E
  • CAT. No.N700043
  • CAS. No.NA
  • Mol. F.C19H18N4O
  • Mol. W.318.37 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 2
Niraparib Nitroso Impurity 2
  • CAT. No.N700044
  • CAS. No.NA
  • Mol. F.C11H15N3O
  • Mol. W.205.26 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 3
Niraparib Nitroso Impurity 3
  • CAT. No.N700045
  • CAS. No.NA
  • Mol. F.C20H20N4O5
  • Mol. W.396.40 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 4
Niraparib Nitroso Impurity 4
  • CAT. No.N700046
  • CAS. No.NA
  • Mol. F.C25H30N4O7
  • Mol. W.498.53 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 5
Niraparib Nitroso Impurity 5
  • CAT. No.N700047
  • CAS. No.NA
  • Mol. F.C20H22N4O5
  • Mol. W.398.41 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 6
Niraparib Nitroso Impurity 6
  • CAT. No.N700048
  • CAS. No.NA
  • Mol. F.C20H21N5O6
  • Mol. W.427.41 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Nitroso Impurity 7
Niraparib Nitroso Impurity 7
  • CAT. No.N700049
  • CAS. No.NA
  • Mol. F.C20H20N4O3
  • Mol. W.364.40 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Carboxylic Acid Nitroso Impurity
Niraparib Carboxylic Acid Nitroso Impurity
  • CAT. No.N700050
  • CAS. No.NA
  • Mol. F.C19H18N4O3
  • Mol. W.350.37 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 7
Niraparib Impurity 7
  • CAT. No.N700052
  • CAS. No.NA
  • Mol. F.C19H20N4O.C7H8O3S.H2O
  • Mol. W.510.61 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Acid Impurity
Niraparib Acid Impurity
  • CAT. No.N700053
  • CAS. No.2086267-12-9
  • Mol. F.C19H19N3O
  • Mol. W.321.37 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 8
Niraparib Impurity 8
  • CAT. No.N700055
  • CAS. No.NA
  • Mol. F.C19H19lN3O2.HCl
  • Mol. W.357.83 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 9
Niraparib Impurity 9
  • CAT. No.N700056
  • CAS. No.NA
  • Mol. F.C20H21N3O2
  • Mol. W.335.40 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 11
Niraparib Impurity 11
  • CAT. No.N700058
  • CAS. No.125541-22-2
  • Mol. F.C16H24N2O2
  • Mol. W.276.40 g/mol
  • Stock Status:Custom Synthesis
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Niraparib Impurity 62(E isomer)
Niraparib Impurity 62(E isomer)
  • CAT. No.N700059
  • CAS. No.68109-89-7
  • Mol. F.C12H14N2O4
  • Mol. W.250.30 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Niraparib Carboxylic Acid
Niraparib Carboxylic Acid
  • CAT. No.N700003
  • CAS. No.1476777-06-6
  • Mol. F.C19H19N3O2
  • Mol. W.321.37 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Niraparib-13C6 Hydrochloride
Niraparib-13C6 Hydrochloride
  • CAT. No.N700004
  • CAS. No.NA
  • Mol. F.C1313C6H21ClN4O
  • Mol. W.362.81 g/mol
  • Stock Status:Custom Synthesis
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Rac-Niraparib D4 Tosylate
Rac-Niraparib D4 Tosylate
  • CAT. No.N700051
  • CAS. No.2247259-52-3 (free base)
  • Mol. F.C19H16D4N4O.C7H8O3S
  • Mol. W.496.61 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Niraparib D4
N-Nitroso Niraparib D4
  • CAT. No.N700057
  • CAS. No.NA
  • Mol. F.C19H15D4N5O2
  • Mol. W.353.41 g/mol
  • Stock Status:Custom Synthesis
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