Nebivolol Hydrochloride Related Compounds & Impurities

Nebivolol Hydrochloride is a beta-adrenergic receptor antagonist used for cardiovascular conditions.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Nebivolol Hydrochloride reference standards, pharmacopeial and non-pharmacopeial Nebivolol Hydrochloride impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Nebivolol Hydrochloride-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Nebivolol Hydrochloride
rac-Nebivolol
Levonebivolol
Benzylated Nebivolol Hydrochloride
Nebivolol Related Compound D
Nebivolol Related Compound C
Defluoro Nebivolol (Mixture of Diastereomers)
Nebivolol Related Compound E
Nebivolol Impurity B
(R,S,S,S)-Defluoro Nebivolol Hydrochloride
1-(6-Fluorochroman-2-yl)-2-{[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino}ethanol
Nebivolol Related Compound A
(R,R,R,R)-Nebivolol
Nebivolol Impurity 3 (RR,SS)
6-Fluoro-2-(oxiran-2-yl)chroman
Nebivolol D Isomer Hydrochloride
Nebivolol D Isomer Hydrochloride
Nebivolol Impurity 21
4-Hydroxy Nebivolol
Nebivolol Impurity 31(RRSS)
Nebivolol Impurity 5 Hydrochloride (RR,SR)
Nebivolol Impurity 12
Nebivolol USP Related Compound E
Rac Nebivolol Hydrochloride
Nebivolol Isomer-2
Nebivolol Impurity 33
Nebivolol Benzyl compound (Nebivolo EP Impurity B)
1-(3,4-dihydro-2H-chromen-2-yl)-2-(methylamino)ethanol
2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone]
Nebivolol (R,R,R,R)-Isomer Hydrochloride
Nebivolol (S,S,S,S)-Isomer
Nebivolol L RSSS Isomer
Nebivolol L SRSS Isomer
Nebivolol (RSSR + SRRS)
D-Nebivolol
NebivololIsomer RSRR Isomer
Nebivolol RRSS Isomer
Nebivolol Isomer (SRSR+RSRS)
Nebivolol Impurity 1
Nebivolol Impurity 43
Nebivolol Isomer (RSRR+RRRR).
Nebivolol Impurity 9
Nebivolol (S,R,S,R) Isomer Hydrochloride
Nebivolol Impurity 12 Hydrochloride (RR,RR)
(R,S,R,S)-Nebivolol
(R,R,S,R)-Nebivolol
(R,S,S,R)-Nebivolol
(S,R,S,R)-Nebivolol
Nebivolol Lactose Adduct
N-Nitroso-Nebivolol
Nebivolol EP Impurity A
Nebivolol EP Impurity B
Nebivolol EP Impurity D
L-Nebivolol Hydrochloride
4-Hydroxy Nebivolol Hydrochoride
N-Formyl Nebivolol
6-fluorochroman-2-carbaldehyde
(S,R,S,S)-Nebivolol Hydrochloride
Nebivolol RSRR Isomer Hydrochloride
Nebivolol Impurity 4 (SS,RS) Hydrochloride
6-fluorochromane-2-carboxylic acid
Nebivolol Impurity 15 (RS)
Nebivolol RRSS Isomers Hydrochloride
Nebivolol Impurity 20 (SS,SS) Hydrochloride
Nebivolol SRSRIsomers Hydrochloride
Nebivolol Impurity 11
Nebivolol SRSSIsomers Hydrochloride
rel-N-Benzyl Nebivolol
Nebivolol B Isomer
(2S)-2-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-{[(4-methylphenyl)sulphonyl]oxy}ethyl acetate
D-Nebivolol (SR,RR)-D6 Hydrochloride
L-Nebivolol (RS,SS)-D6 Hydrochloride
Nebivolol Impurity 37(RRRS)
Nebivolol Impurity 50
Nebivolol Related Compound A
Nebivolol Des-Fluoro Impurity
N-Nitroso Desfluoro Nebivolol
Nebivolol Nitroso Impurity 1
Nebivolol
Nebivolol Ethanol Impurity
Nebivolol Impurity 66 (RS,SR)
Nebivolol Impurity 67
Nebivolol Impurity 68
(RR,RR)-Nebivolol
Nebivolol Lactose Adduct Hydrochloride
Nebivolol Impurity 69
Didefluoro Nebivolol
Desfluoro Nebivolol (SRSS and RSRR)
Desfluoro Nebivolol (SRRS and RSSR)
1-(6-fluorochroman-2-yl)ethanone
Nebivolol Impurity 58
N-Benzyl (-)-Nebivolol (SSRS)
Nebivolol Impurity 40 (SRSS)
Nebivolol Impurity 41 (SRRR)
Nebivolol EP Impurity B Hydrochloride
Nebivolol Impurity 70
Nebivolol Impurity 71
Nebivolol EP Impurity C
Nebivolol Isomer Impurity
Nebivolol Impurity 27
Nebivolol Related Compound D
Nebivolol Impurity 29
Nebivolol Impurity 30
Nebivolol Related Compound B
Nebivolol Impurity 8
Nebivolol Impurity 10
Desfluoro Nebivolol
Nebivolol Impurity 13
Nebivolol Hydrochloride Impurity 1
Nebivolol Impurity 16
Nebivolol Impurity 2
Benzylated Nebivolol Isomeric Mixture A
Nebivolol Stage-V Isomer- B Chloride Impurity
Nebivolol Impurity 7 (SR)
Nebivolol Impurity 17 (RS)
Nebivolol Impurity 18 (RR)
Nebivolol Impurity 19

Metabolites

Nebivolol-O-beta-D-Glucuronide
Nebivolol Impurity 14

Isotope Labelled Compounds

Racemic Nebivolol-D4 HCl (Mixture of Diastereomers)
rac Nebivolol-D4 (Major)
N-Nitroso rac-Nebivolol-D4 (Mixture of Diastereomers)
(-)-Nebivolol-d4 Hydrochloride
D-Nebivolol D4
Nebivolol D4
S-Nebivolol D4