Metoprolol Related Compounds & Impurities

Metoprolol is a cardioselective beta-1 blocker used for hypertension, angina, heart failure and myocardial infarction secondary prevention.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Metoprolol reference standards, pharmacopeial and non-pharmacopeial Metoprolol impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Metoprolol-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Metoprolol Tartrate
Metoprolol Tartrate
  • CAT. No.M030000
  • CAS. No.56392-17-7
  • Mol. F.C34H56N2O12
  • Mol. W.684.81 g/mol
  • Stock Status:Instock
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Metoprolol
Metoprolol
  • CAT. No.M030000A
  • CAS. No.51384-51-1
  • Mol. F.C15H25NO3
  • Mol. W.267.36 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity A
Metoprolol EP Impurity A
  • CAT. No.M030001
  • CAS. No.109632-08-8
  • Mol. F.C14H23NO3
  • Mol. W.253.34 g / mol
  • Stock Status:Instock
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Metoprolol EP Impurity A Hydrochloride
Metoprolol EP Impurity A Hydrochloride
  • CAT. No.M030001A
  • CAS. No.109632-08-8(base)
  • Mol. F.C14H23NO3.HCl
  • Mol. W.289.80 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol EP Impurity B
Metoprolol EP Impurity B
  • CAT. No.M030002
  • CAS. No.56718-71-9
  • Mol. F.C9H12O2
  • Mol. W.152.19 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity C
Metoprolol EP Impurity C
  • CAT. No.M030003
  • CAS. No.29122-74-5
  • Mol. F.C13H19NO3
  • Mol. W.237.29 g/mol
  • Stock Status:Limited Stock
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Metoprolol EP Impurity C Hydrochloride
Metoprolol EP Impurity C Hydrochloride
  • CAT. No.M030003A
  • CAS. No.29122-74-5
  • Mol. F.C13H19NO3 .HCl
  • Mol. W.273.76 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity D
Metoprolol EP Impurity D
  • CAT. No.M030004
  • CAS. No.62572-90-1
  • Mol. F.C12H18O4
  • Mol. W.226.27 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity E
Metoprolol EP Impurity E
  • CAT. No.M030005
  • CAS. No.163685-38-9
  • Mol. F.C15H25NO3
  • Mol. W.267.36 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity F
Metoprolol EP Impurity F
  • CAT. No.M030006
  • CAS. No.7695-63-8
  • Mol. F.C12H19NO2
  • Mol. W.209.28 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity G
Metoprolol EP Impurity G
  • CAT. No.M030007
  • CAS. No.501-94-0
  • Mol. F.C8H10O2
  • Mol. W.138.16 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity H
Metoprolol EP Impurity H
  • CAT. No.M030008
  • CAS. No.62572-94-5
  • Mol. F.C14H23NO3
  • Mol. W.253.33 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity J
Metoprolol EP Impurity J
  • CAT. No.M030009
  • CAS. No.163685-37-8
  • Mol. F.C18H31NO5
  • Mol. W.341.44 g/mol
  • Stock Status:Instock
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Metoprolol EP Impurity M
Metoprolol EP Impurity M
  • CAT. No.M030010
  • CAS. No.73313-36-7
  • Mol. F.C9H22N2O.2HCl
  • Mol. W.247.21 g / mol
  • Stock Status:Instock
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Metoprolol EP Impurity M (Base)
Metoprolol EP Impurity M (Base)
  • CAT. No.M030010A
  • CAS. No.343785-33-1
  • Mol. F.C9H22N2O
  • Mol. W.174.28 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol EP Impurity N
Metoprolol EP Impurity N
  • CAT. No.M030011
  • CAS. No.6452-57-9
  • Mol. F.C6H15NO2
  • Mol. W.133.18 g/mol
  • Stock Status:Instock
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Metoprolol USP Impurity- D
Metoprolol USP Impurity- D
  • CAT. No.M030012
  • CAS. No.154784-36-8
  • Mol. F.C27H41NO6
  • Mol. W.475.61 g / mol
  • Stock Status:Custom Synthesis
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Metoprolol EP Impurity O Hydrochloride
Metoprolol EP Impurity O Hydrochloride
  • CAT. No.M030012A
  • CAS. No.1486464-40-7
  • Mol. F.C27H41NO6.HCl
  • Mol. W.512.08 g/mol
  • Stock Status:Instock
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Metoprolol Dimer
Metoprolol Dimer
  • CAT. No.M030013
  • CAS. No.230975-30-1
  • Mol. F.C21H28O5
  • Mol. W.360.44 g/mol
  • Stock Status:Instock
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Metoprolol Methoxy Epoxide Impurity
Metoprolol Methoxy Epoxide Impurity
  • CAT. No.M030014
  • CAS. No.56718-70-8
  • Mol. F.C12H16O3
  • Mol. W.208.25 g/mol
  • Stock Status:Instock
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Metoprolol Acid Sodium Salt
Metoprolol Acid Sodium Salt
  • CAT. No.M030015
  • CAS. No.56392-14-4
  • Mol. F.C14H21NO4
  • Mol. W.267.32 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Succinate
Metoprolol Succinate
  • CAT. No.M030016
  • CAS. No.98418-47-4
  • Mol. F.2(C15H25NO3).C4H6O4
  • Mol. W.652.82 g/mol
  • Stock Status:Instock
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Metoprolol Tartrate USP Related compound- B
Metoprolol Tartrate USP Related compound- B
  • CAT. No.M030017
  • CAS. No.56718-76-4
  • Mol. F.C12H17ClO3
  • Mol. W.244.71 g / mol
  • Stock Status:Instock
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P-Formyl Metoprolol
P-Formyl Metoprolol
  • CAT. No.M030020
  • CAS. No.NA
  • Mol. F.C13H19NO3.HCl
  • Mol. W.273.76 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Acid Methyl Ester
Metoprolol Acid Methyl Ester
  • CAT. No.M030021
  • CAS. No.29121-23-1
  • Mol. F.C15H23NO4
  • Mol. W.281.35 g/mol
  • Stock Status:Instock
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alpha-Hydroxy Metoprolol
alpha-Hydroxy Metoprolol
  • CAT. No.M030023
  • CAS. No.56392-16-6
  • Mol. F.C15H25NO4
  • Mol. W.283.36 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol S-Isomer
Metoprolol S-Isomer
  • CAT. No.M030024
  • CAS. No.81024-42-2
  • Mol. F.C15H25NO3
  • Mol. W.267.36 g/mol
  • Stock Status:Instock
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Esmolol Impurity 2
Esmolol Impurity 2
  • CAT. No.M030025
  • CAS. No.50666-68-7
  • Mol. F.C6H14ClNO
  • Mol. W.151.63 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Impurity 6
Metoprolol Impurity 6
  • CAT. No.M030026
  • CAS. No.69628-98-4
  • Mol. F.C9H11NO3
  • Mol. W.181.19 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Process Impurity 4
Metoprolol Process Impurity 4
  • CAT. No.M030027
  • CAS. No.84803-56-5
  • Mol. F.C9H13NO
  • Mol. W.151.21 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol hydroxy Epoxide
Metoprolol hydroxy Epoxide
  • CAT. No.M030028
  • CAS. No.104857-48-9
  • Mol. F.C11H14O3
  • Mol. W.194.23 g/mol
  • Stock Status:Instock
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Metoprolol Epoxy Impurity
Metoprolol Epoxy Impurity
  • CAT. No.M030029
  • CAS. No.122-60-1
  • Mol. F.C9H10O2
  • Mol. W.150.17 g/mol
  • Stock Status:Instock
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Metoprolol Impurity 4
Metoprolol Impurity 4
  • CAT. No.M030030
  • CAS. No.123195-72-2
  • Mol. F.C12H18O2
  • Mol. W.194.27 g/mol
  • Stock Status:Instock
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Metoprolol Impurity 2
Metoprolol Impurity 2
  • CAT. No.M030033
  • CAS. No.NA
  • Mol. F.C28H47NO11
  • Mol. W.573.68 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Lactose Adduct
Metoprolol Lactose Adduct
  • CAT. No.M030034
  • CAS. No.NA
  • Mol. F.C27H45NO13
  • Mol. W.591.70 g/mol
  • Stock Status:Custom Synthesis
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N-Nitrosometoprolol
N-Nitrosometoprolol
  • CAT. No.M030035
  • CAS. No.138768-62-4
  • Mol. F.C15H24N2O4
  • Mol. W.296.36 g/mol
  • Stock Status:Instock
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1-Chloro-3-isopropylamino-2-propanol Hydrochloride
1-Chloro-3-isopropylamino-2-propanol Hydrochloride
  • CAT. No.M030036
  • CAS. No.39552-14-2
  • Mol. F.C6H14ClNO.HCl
  • Mol. W.188.10 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol R-Isomer
Metoprolol R-Isomer
  • CAT. No.M030037
  • CAS. No.81024-43-3
  • Mol. F.C15H25NO3
  • Mol. W.267.36 g/mol
  • Stock Status:Custom Synthesis
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2-(2-Isopropoxyethoxy)ethanol
2-(2-Isopropoxyethoxy)ethanol
  • CAT. No.M030038
  • CAS. No.5412-01-1
  • Mol. F.C7H16O3
  • Mol. W.148.20 g/mol
  • Stock Status:Custom Synthesis
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2-(2-Methoxyphenoxy)-N-methylethanamine
2-(2-Methoxyphenoxy)-N-methylethanamine
  • CAT. No.M030039
  • CAS. No.72955-82-9
  • Mol. F.C10H15NO2
  • Mol. W.181.23 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Impurity T
Metoprolol Impurity T
  • CAT. No.M030040
  • CAS. No.73723-85-0
  • Mol. F.C15H23NO4
  • Mol. W.281.35 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Fumarate
Metoprolol Fumarate
  • CAT. No.M030041
  • CAS. No.119637-66-0
  • Mol. F.C19H29NO7
  • Mol. W.383.44 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol EP Impurity A
N-Nitroso Metoprolol EP Impurity A
  • CAT. No.M030042
  • CAS. No.NA
  • Mol. F.C14H22N2O4
  • Mol. W.282.34 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol EP Impurity C
N-Nitroso Metoprolol EP Impurity C
  • CAT. No.M030043
  • CAS. No.NA
  • Mol. F.C13H18N2O4
  • Mol. W.26.29 g/mol
  • Stock Status:Custom Synthesis
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N-Desisopropyl Metoprolol
N-Desisopropyl Metoprolol
  • CAT. No.M030044
  • CAS. No.74027-60-4
  • Mol. F.C12H19NO3
  • Mol. W.225.28 g/mol
  • Stock Status:Custom Synthesis
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1-(chloro(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
1-(chloro(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
  • CAT. No.M030046
  • CAS. No.NA
  • Mol. F.C15H24ClNO3
  • Mol. W.301.81 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Dimer Impurity 1
Metoprolol Dimer Impurity 1
  • CAT. No.M030047
  • CAS. No.NA
  • Mol. F.C12H28N2O3
  • Mol. W.248.36 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol EP Impurity J
N-Nitroso Metoprolol EP Impurity J
  • CAT. No.M030048
  • CAS. No.NA
  • Mol. F.C18H30N2O6
  • Mol. W.370.40 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol EP Impurity E
N-Nitroso Metoprolol EP Impurity E
  • CAT. No.M030049
  • CAS. No.NA
  • Mol. F.C15H24N2O4
  • Mol. W.296.40 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Impurity 10
Metoprolol Impurity 10
  • CAT. No.M030051
  • CAS. No.1416440-64-6
  • Mol. F.C15H22O5
  • Mol. W.282.33 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Impurity 1
Metoprolol Impurity 1
  • CAT. No.M030052
  • CAS. No.27822-62-4
  • Mol. F.C14H21NO2
  • Mol. W.235.33 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol Impurity 3
Metoprolol Impurity 3
  • CAT. No.M030053
  • CAS. No.NA
  • Mol. F.C12H18O4
  • Mol. W.226.27 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol Impurity 1
N-Nitroso Metoprolol Impurity 1
  • CAT. No.M030054
  • CAS. No.NA
  • Mol. F.C15H22N2O5
  • Mol. W.310.35 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol Impurity 2
N-Nitroso Metoprolol Impurity 2
  • CAT. No.M030055
  • CAS. No.NA
  • Mol. F.C16H25NO4
  • Mol. W.295.37 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol Impurity 3
N-Nitroso Metoprolol Impurity 3
  • CAT. No.M030056
  • CAS. No.NA
  • Mol. F.C10H12O3
  • Mol. W.180.20 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Metoprolol-D7 Hydrochloride
Metoprolol-D7 Hydrochloride
  • CAT. No.M030018
  • CAS. No.1219798-61-4
  • Mol. F.C15H19D7ClNO3
  • Mol. W.310.87 g/mol
  • Stock Status:Instock
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Metoprolol Acid D5
Metoprolol Acid D5
  • CAT. No.M030031
  • CAS. No.1215404-47-9
  • Mol. F.C14H16D5NO4
  • Mol. W.272.35 g/mol
  • Stock Status:Custom Synthesis
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Metoprolol D5
Metoprolol D5
  • CAT. No.M030032
  • CAS. No.959786-79-9
  • Mol. F.C15H20D5NO3
  • Mol. W.272.39 g/mol
  • Stock Status:Custom Synthesis
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Alpha-Hydroxy Metoprolol D5(Mixture of Diastereomers)
Alpha-Hydroxy Metoprolol D5(Mixture of Diastereomers)
  • CAT. No.M030045
  • CAS. No.1189934-03-9
  • Mol. F.C15H20D5NO4
  • Mol. W.288.39 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Metoprolol D6
N-Nitroso Metoprolol D6
  • CAT. No.M030050
  • CAS. No.NA
  • Mol. F.C15H18D6N2O4
  • Mol. W.302.40 g/mol
  • Stock Status:Custom Synthesis
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