Macitentan Related Compounds & Impurities

Macitentan is a dual endothelin ETA/ETB receptor antagonist with improved tissue penetration, used for pulmonary arterial hypertension.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Macitentan reference standards, pharmacopeial and non-pharmacopeial Macitentan impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Macitentan-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Macitentan
Macitentan
  • CAT. No.M790000
  • CAS. No.441798-33-0
  • Mol. F.C19H20Br2N6O4S
  • Mol. W.588.27 g/mol
  • Stock Status:Instock
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O-Desbromo-pyrimidinyl Macitentan
O-Desbromo-pyrimidinyl Macitentan
  • CAT. No.M790005
  • CAS. No.1393813-43-8
  • Mol. F.C15H19BrN4O4S
  • Mol. W.431.30 g/mol
  • Stock Status:Instock
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Macitentan Pyrimidine Amine Impurity
Macitentan Pyrimidine Amine Impurity
  • CAT. No.M790006
  • CAS. No.1393813-42-7
  • Mol. F.C13H14BrClN4O2S
  • Mol. W.405.70 g/mol
  • Stock Status:Instock
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Despropylaminosulfonyl Macitentan
Despropylaminosulfonyl Macitentan
  • CAT. No.M790007
  • CAS. No.1433875-21-8
  • Mol. F.C16H13Br2N5O2
  • Mol. W.467.11 g/mol
  • Stock Status:Instock
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Macitentan Impurity 15
Macitentan Impurity 15
  • CAT. No.M790008
  • CAS. No.NA
  • Mol. F.C19H19Br2N5O2
  • Mol. W.509.19 g/mol
  • Stock Status:Instock
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Macitentan Dimer Impurity
Macitentan Dimer Impurity
  • CAT. No.M790009
  • CAS. No.2089065-77-8
  • Mol. F.C28H32Br2N8O6S2
  • Mol. W.800.54 g/mol
  • Stock Status:Instock
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Macitentan Impurity 2
Macitentan Impurity 2
  • CAT. No.M790012
  • CAS. No.2211054-90-7
  • Mol. F.C10H8Br2N4O2
  • Mol. W.376.00 g/mol
  • Stock Status:Instock
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N-Despropyl-N-Ethyl Macitentan
N-Despropyl-N-Ethyl Macitentan
  • CAT. No.M790015
  • CAS. No.441796-13-0
  • Mol. F.C18H18Br2N6O4S
  • Mol. W.574.25 g/mol
  • Stock Status:Instock
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Macitentan n-butyl analogue
Macitentan n-butyl analogue
  • CAT. No.M790016
  • CAS. No.556797-16-1
  • Mol. F.C20H21Br2N5O4S
  • Mol. W.587.28 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 14
Macitentan Impurity 14
  • CAT. No.M790017
  • CAS. No.2211059-05-9
  • Mol. F.C12H12BrN3O2
  • Mol. W.310.15 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 4
Macitentan Impurity 4
  • CAT. No.M790018
  • CAS. No.NA
  • Mol. F.C15H18BrN3O2
  • Mol. W.352.23 g/mol
  • Stock Status:Instock
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Macitentan Isopropyl Impurity
Macitentan Isopropyl Impurity
  • CAT. No.M790019
  • CAS. No.NA
  • Mol. F.C19H20Br2N6O4S
  • Mol. W.588.27 g/mol
  • Stock Status:Instock
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N-Despropyl Macitentan
N-Despropyl Macitentan
  • CAT. No.M790020
  • CAS. No.1103522-45-7
  • Mol. F.C16H14Br2N6O4S
  • Mol. W.546.19 g/mol
  • Stock Status:Custom Synthesis
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N-(5-(4-chlorophenyl)-6(2-((5-chloro-2pyridinyl)oxy)ethoxy) 4-pyrimidinyl)-N'-propylsulfamide
N-(5-(4-chlorophenyl)-6(2-((5-chloro-2pyridinyl)oxy)ethoxy) 4-pyrimidinyl)-N'-propylsulfamide
  • CAT. No.M790021
  • CAS. No.NA
  • Mol. F.C20H21Cl2N5O4S
  • Mol. W.498.38 g/mol
  • Stock Status:Instock
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Macitentan 4-Chloro Analog
Macitentan 4-Chloro Analog
  • CAT. No.M790024
  • CAS. No.441798-36-3
  • Mol. F.C19H20BrClN6O4S
  • Mol. W.543.82 g/mol
  • Stock Status:Instock
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Macitentan Impurity H
Macitentan Impurity H
  • CAT. No.M790026
  • CAS. No.2300968-85-6
  • Mol. F.C19H22N6O4S
  • Mol. W.430.48 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Macitentan
N-Nitroso Macitentan
  • CAT. No.M790027
  • CAS. No.NA
  • Mol. F.C19H19Br2N7O5S
  • Mol. W.617.27 g/mol
  • Stock Status:Custom Synthesis
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N-nitroso N-Propyl Sulfamide
N-nitroso N-Propyl Sulfamide
  • CAT. No.M790028
  • CAS. No.NA
  • Mol. F.C3H9N3O3S
  • Mol. W.167.20 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 25
Macitentan Impurity 25
  • CAT. No.M790029
  • CAS. No.1393813-40-5
  • Mol. F.C8H18N2O4S
  • Mol. W.238.31 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 17
Macitentan Impurity 17
  • CAT. No.M790030
  • CAS. No.2211054-46-3
  • Mol. F.C10H8BrN3O
  • Mol. W.266.09 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Stage-I Hydroxy Impurity
Macitentan Stage-I Hydroxy Impurity
  • CAT. No.M790031
  • CAS. No.2365406-85-3
  • Mol. F.C13H15BrN4O3S
  • Mol. W.387.25 g/mol
  • Stock Status:Instock
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5-(3-Bromophenyl)-4,6-dichloropyrimidine
5-(3-Bromophenyl)-4,6-dichloropyrimidine
  • CAT. No.M790032
  • CAS. No.1532412-37-5
  • Mol. F.C10H5BrCl2N2
  • Mol. W.303.97 g/mol
  • Stock Status:Custom Synthesis
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5-(2-Bromophenyl)-4,6-dichloropyrimidine
5-(2-Bromophenyl)-4,6-dichloropyrimidine
  • CAT. No.M790033
  • CAS. No.1516860-25-5
  • Mol. F.C10H5BrCl2N2
  • Mol. W.303.97 g/mol
  • Stock Status:Custom Synthesis
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5-(4-bromophenyl)-6-chloropyrimidin-4-ol
5-(4-bromophenyl)-6-chloropyrimidin-4-ol
  • CAT. No.M790034
  • CAS. No.NA
  • Mol. F.C10H6BrClN2O
  • Mol. W.285.52 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Macitentan Dimer Impurity
N-Nitroso Macitentan Dimer Impurity
  • CAT. No.M790035
  • CAS. No.NA
  • Mol. F.C28H30Br2N10O8S2
  • Mol. W.858.50 g/mol
  • Stock Status:Custom Synthesis
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S-Despropylamino S-Methyl Macitentan
S-Despropylamino S-Methyl Macitentan
  • CAT. No.M790036
  • CAS. No.556796-88-4
  • Mol. F.C17H15Br2N5O4S
  • Mol. W.545.21 g/mol
  • Stock Status:Custom Synthesis
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N-Despropyl-N-Methyl Macitentan
N-Despropyl-N-Methyl Macitentan
  • CAT. No.M790037
  • CAS. No.441798-25-0
  • Mol. F.C17H16Br2N6O4S
  • Mol. W.560.20 g/mol
  • Stock Status:Custom Synthesis
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5-desbromo-5-Chloro Macitentan
5-desbromo-5-Chloro Macitentan
  • CAT. No.M790039
  • CAS. No.2443747-63-3
  • Mol. F.C19H20BrClN6O4S
  • Mol. W.543.82 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Pyrimidine Amine Impurity
N-Nitroso Pyrimidine Amine Impurity
  • CAT. No.M790040
  • CAS. No.NA
  • Mol. F.C13H13BrClN5O3S
  • Mol. W.434.70 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Nitroso Pyrimidine N-Propyl Impurity
Macitentan Nitroso Pyrimidine N-Propyl Impurity
  • CAT. No.M790041
  • CAS. No.NA
  • Mol. F.C19H18Br2N6O3
  • Mol. W.538.20 g/mol
  • Stock Status:Custom Synthesis
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N-Boc-sulfamoyl Chloride
N-Boc-sulfamoyl Chloride
  • CAT. No.M790042
  • CAS. No.147000-89-3
  • Mol. F.C5H10ClNO4S
  • Mol. W.215.66 g/mol
  • Stock Status:Custom Synthesis
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5-Des-Bromo-Macitentan
5-Des-Bromo-Macitentan
  • CAT. No.M790043
  • CAS. No.2211059-00-4
  • Mol. F.C19H21BrN6O4S
  • Mol. W.509.38 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 3
Macitentan Impurity 3
  • CAT. No.M790044
  • CAS. No.NA
  • Mol. F.C8H11BrN2O3
  • Mol. W.263.09 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Macitentan Impurity 1
N-Nitroso Macitentan Impurity 1
  • CAT. No.M790045
  • CAS. No.NA
  • Mol. F.C15H18BrN5O5S
  • Mol. W.459.31 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 5
Macitentan Impurity 5
  • CAT. No.M790046
  • CAS. No.2518002-08-7
  • Mol. F.C11H8BrClN2O
  • Mol. W.299.55 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 6
Macitentan Impurity 6
  • CAT. No.M790047
  • CAS. No.2514735-21-6
  • Mol. F.C13H13BrClN3
  • Mol. W.326.62 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 7
Macitentan Impurity 7
  • CAT. No.M790048
  • CAS. No.NA
  • Mol. F.C14H17BrN4O3S
  • Mol. W.401.28 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 8
Macitentan Impurity 8
  • CAT. No.M790049
  • CAS. No.NA
  • Mol. F.C14H15BrN2O4
  • Mol. W.355.18 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 9
Macitentan Impurity 9
  • CAT. No.M790050
  • CAS. No.NA
  • Mol. F.C17H23BrN4O5S
  • Mol. W.475.36 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 10
Macitentan Impurity 10
  • CAT. No.M790051
  • CAS. No.NA
  • Mol. F.C13H15BrN4O3S
  • Mol. W.387.25 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Macitentan Hydroxy N-Propyl Impurity
N-Nitroso Macitentan Hydroxy N-Propyl Impurity
  • CAT. No.M790052
  • CAS. No.3104323-52-3
  • Mol. F.C15H17BrN4O3
  • Mol. W.381.22 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 11
Macitentan Impurity 11
  • CAT. No.M790053
  • CAS. No.3974-18-3
  • Mol. F.C10H5Cl3N2
  • Mol. W.259.52 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 1
Macitentan Impurity 1
  • CAT. No.M790054
  • CAS. No.2300968-87-8
  • Mol. F.C19H21BrN6O4S
  • Mol. W.509.38 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 12
Macitentan Impurity 12
  • CAT. No.M790055
  • CAS. No.NA
  • Mol. F.C18H17Br2N5O2
  • Mol. W.495.17 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 13
Macitentan Impurity 13
  • CAT. No.M790056
  • CAS. No.NA
  • Mol. F.C19H20Br2N6O5S
  • Mol. W.604.27 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Impurity 16
Macitentan Impurity 16
  • CAT. No.M790057
  • CAS. No.NA
  • Mol. F.C6H7BrN2O2
  • Mol. W.219.00 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

N-Despropyl Macitentan
N-Despropyl Macitentan
  • CAT. No.M790001
  • CAS. No.1103522-45-7
  • Mol. F.C16H14Br2N6O4S
  • Mol. W.546.20 g/mol
  • Stock Status:Instock
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Macitentan ACT-373898
Macitentan ACT-373898
  • CAT. No.M790025
  • CAS. No.1433875-14-9
  • Mol. F.C15H17BrN4O5S
  • Mol. W.445.29 g/mol
  • Stock Status:Custom Synthesis
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Macitentan Metabolite M7
Macitentan Metabolite M7
  • CAT. No.M790038
  • CAS. No.NA
  • Mol. F.C16H13Br2N5O5S
  • Mol. W.547.18 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Macitentan D4
Macitentan D4
  • CAT. No.M790003
  • CAS. No.1258428-05-5
  • Mol. F.C19H16D4Br2N6O4S
  • Mol. W.592.30 g/mol
  • Stock Status:Instock
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N-Despropyl Macitentan-D4
N-Despropyl Macitentan-D4
  • CAT. No.M790004
  • CAS. No.NA
  • Mol. F.C16H10D4Br2N6O4S
  • Mol. W.550.22 g/mol
  • Stock Status:Instock
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[13C2, 2H4]-Macitentan Metabolite
[13C2, 2H4]-Macitentan Metabolite
  • CAT. No.M790022
  • CAS. No.NA
  • Mol. F.C40H10D2Br2N6O4S
  • Mol. W.834.45 g/mol
  • Stock Status:Custom Synthesis
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Macitentan 13C2 D4
Macitentan 13C2 D4
  • CAT. No.M790023
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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