Lubiprostone Related Compounds & Impurities

Lubiprostone is a ClC-2 chloride channel activator that enhances intestinal fluid secretion, used for chronic idiopathic constipation and IBS-C.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Lubiprostone reference standards, pharmacopeial and non-pharmacopeial Lubiprostone impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Lubiprostone-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Lubiprostone
Lubiprostone
  • CAT. No.L270000
  • CAS. No.136790-76-6
  • Mol. F.C20H32F2O5
  • Mol. W.390.46 g/mol
  • Stock Status:Limited Stock
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Lubiprostone Related Compound 7
Lubiprostone Related Compound 7
  • CAT. No.L270004
  • CAS. No.NA
  • Mol. F.C20H32F2O5
  • Mol. W.390.47 g/mol
  • Stock Status:Custom Synthesis
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Lubiprostone impurity 1
Lubiprostone impurity 1
  • CAT. No.L270005
  • CAS. No.136790-76-6
  • Mol. F.C20H32F2O5
  • Mol. W.390.47g/mol
  • Stock Status:Limited Stock
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7-((1R,2R)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid
7-((1R,2R)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid
  • CAT. No.L270008
  • CAS. No.NA
  • Mol. F.C20H32F2O4
  • Mol. W.374.46 g/mol
  • Stock Status:Instock
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7-((1R,2R,3R)-2-(4,4-difluoro-3-oxo-1- octyl)-3-(phenylmethoxy)-5-oxo- cyclopentyl)heptanoic Acid
7-((1R,2R,3R)-2-(4,4-difluoro-3-oxo-1- octyl)-3-(phenylmethoxy)-5-oxo- cyclopentyl)heptanoic Acid
  • CAT. No.L270011
  • CAS. No.NA
  • Mol. F.C27H38F2O5
  • Mol. W.480.58 g/mol
  • Stock Status:Custom Synthesis
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7-((1R,2S)-2-(4,4-difluoro-3-oxo-1-octyl)-5-oxo-3-cyclopentenyl)heptanoic Acid
7-((1R,2S)-2-(4,4-difluoro-3-oxo-1-octyl)-5-oxo-3-cyclopentenyl)heptanoic Acid
  • CAT. No.L270012
  • CAS. No.NA
  • Mol. F.C20H30F2O4
  • Mol. W.372.45 g/mol
  • Stock Status:Custom Synthesis
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6-(6-Carboxyhexyl)-2-(1,1-difluoropentyl)2,8-dihydroxybicyclo[3.2.1]octan-7-one
6-(6-Carboxyhexyl)-2-(1,1-difluoropentyl)2,8-dihydroxybicyclo[3.2.1]octan-7-one
  • CAT. No.L270013
  • CAS. No.NA
  • Mol. F.C20H32F2O5
  • Mol. W.390.46 g/mol
  • Stock Status:Custom Synthesis
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1-(6-Carboxyhexyl)-8-(1,1-difluoropentyl)-8-hydroxybicyclo[3.3.0]oct-3-en-2-one
1-(6-Carboxyhexyl)-8-(1,1-difluoropentyl)-8-hydroxybicyclo[3.3.0]oct-3-en-2-one
  • CAT. No.L270014
  • CAS. No.NA
  • Mol. F.C20H30F2O4
  • Mol. W.372.45 g/mol
  • Stock Status:Custom Synthesis
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3aR,4R,5R,6aS)-2-oxo-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
3aR,4R,5R,6aS)-2-oxo-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
  • CAT. No.L270015
  • CAS. No.NA
  • Mol. F.C13H18O5
  • Mol. W.254.28 g/mol
  • Stock Status:Custom Synthesis
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(3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
(3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
  • CAT. No.L270016
  • CAS. No.NA
  • Mol. F.C13H20O5
  • Mol. W.256.29 g/mol
  • Stock Status:Custom Synthesis
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((+/-)-Corey Lactone Diol
((+/-)-Corey Lactone Diol
  • CAT. No.L270017
  • CAS. No.54423-47-1
  • Mol. F.C8H12O4
  • Mol. W.172.18 g/mol
  • Stock Status:Custom Synthesis
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Lubiprostone Impurity 1
Lubiprostone Impurity 1
  • CAT. No.L270018
  • CAS. No.NA
  • Mol. F.C20H32F2O5
  • Mol. W.390.46 g/mol
  • Stock Status:Custom Synthesis
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Lubiprostone Impurity ll
Lubiprostone Impurity ll
  • CAT. No.L270019
  • CAS. No.NA
  • Mol. F.C20H32F2O5
  • Mol. W.390.46 g/mol
  • Stock Status:Custom Synthesis
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Lubiprostone Hemiketal
Lubiprostone Hemiketal
  • CAT. No.L270021
  • CAS. No.333963-40-9
  • Mol. F.C20H32F2O5
  • Mol. W.390.46 g/mol
  • Stock Status:Under Synthesis
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5-Amino Lenalidomide
5-Amino Lenalidomide
  • CAT. No.L270022
  • CAS. No.191732-74-8
  • Mol. F.C13H13N3O3
  • Mol. W.259.26 g/mol
  • Stock Status:Custom Synthesis
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7-((1R,2R,3R)-2-(4,4-difluoro-3-oxooctyl)-5-oxo-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoic acid
7-((1R,2R,3R)-2-(4,4-difluoro-3-oxooctyl)-5-oxo-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoic acid
  • CAT. No.L270023
  • CAS. No.NA
  • Mol. F.C25H40F2O6
  • Mol. W.474.58 g/mol
  • Stock Status:Custom Synthesis
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cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate
cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate
  • CAT. No.L270024
  • CAS. No.NA
  • Mol. F.C27H44F2O5
  • Mol. W.486.63 g/mol
  • Stock Status:Custom Synthesis
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(Z)-benzyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate
(Z)-benzyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate
  • CAT. No.L270025
  • CAS. No.NA
  • Mol. F.C27H36F2O5
  • Mol. W.478.57 g/mol
  • Stock Status:Custom Synthesis
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7-(2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanamide (RS)
7-(2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanamide (RS)
  • CAT. No.L270026
  • CAS. No.NA
  • Mol. F.C20H31F2NO3
  • Mol. W.371.46 g/mol
  • Stock Status:Custom Synthesis
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Lubiprostone Impurity 6
Lubiprostone Impurity 6
  • CAT. No.L270027
  • CAS. No.136790-78-8
  • Mol. F.C32H44F2O5
  • Mol. W.546.69 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

15-Hydroxy Lubiprostone
15-Hydroxy Lubiprostone
  • CAT. No.L270001
  • CAS. No.47592-30-4
  • Mol. F.C20H34F2O5
  • Mol. W.392.48 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Lubiprostone D7
Lubiprostone D7
  • CAT. No.L270002
  • CAS. No.1217675-13-2
  • Mol. F.C20H25D7F2O5
  • Mol. W.397.51 g/mol
  • Stock Status:Custom Synthesis
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15-Hydroxy Lubiprostone-d4
15-Hydroxy Lubiprostone-d4
  • CAT. No.L270003
  • CAS. No.NA
  • Mol. F.C20H30D4F2O5
  • Mol. W.396.51 g/mol
  • Stock Status:Custom Synthesis
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15-Hydroxy Lubiprostone-D7
15-Hydroxy Lubiprostone-D7
  • CAT. No.L270020
  • CAS. No.475992-30-4(non-labelled)
  • Mol. F.C20H27D7F2O5
  • Mol. W.399.52 g/mol
  • Stock Status:Custom Synthesis
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