Losartan Related Compounds & Impurities

Losartan is the first angiotensin II AT1 receptor blocker (ARB) approved for hypertension, diabetic nephropathy and stroke prevention.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Losartan reference standards, pharmacopeial and non-pharmacopeial Losartan impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Losartan-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Losartan Potassium
Losartan
Losartan EP Impurity A
Losartan EP Impurity B
Losartan EP Impurity C
Losartan EP Impurity D
Losartan EP Impurity E
Losartan EP Impurity F
Losartan EP Impurity G
Losartan EP Impurity H
Losartan EP Impurity I
Losartan EP Impurity J
Losartan EP Impurity K
Losartan Carboxylic Acid
Losartan Trityl Methyl Ether Impurity
Losartan Bromo N1 Trityl Impurity
N1,O-Ditrityl Losartan
Des[2`-(1H-tetrazol-5-yl)] 2-Cyanolosartan
Losartan Impurity 30
Losartan Impurity 36
Losartan Impurity 22
Losartan EP Impurity L
Losartan Impurity L Potassium
Losartan EP Impurity M
Losartan Impurity M Potassium
Losartan Impurity 35
Candesartan Dibromo N2-Trityl Impurity
2`-(2H-Tetrazol-5-yl)-[1,1`-biphenyl]-4-carbaldehyde
Losartan Ethyl Ether Impurity
Losartan Bromo N2 Trityl Impurity
Losartan Methyl Ether
Losartan Butyl Ether
Mixture of Losartan Impurity L+ Losartan Impurity M
Valsartan Impurity 15
Losartan Isopropyl Ether
Losartan Azide Impurity
Losartan Impurity 34
Losartan Impurity G
Losartan Impurity K
Losartan alpha-Butyl-Losartan Aldehyde Adduct
2`-(bromomethyl)-[1,1`-biphenyl]-2-carbonitrile
2-Butyl-4-chloro-1H-imidazole
Nitroso Losartan
Losartan Impurity 20
Losartan Impurity 12
4`-[[2-butyl-4-chloro-5-(chloromethyl)-1H-imidazol-1-yl]methyl](1,1`-biphenyl)-2-carbonitrile
(2`-(1H-tetrazol-5-yl)-[1,1`-biphenyl]-4-yl)methanamine
BCFI Nitroso Impurity
Losartan Impurity 7
Losartan Azide Nitrile Impurity
Losartan Isomer Dichloro Nitrile
Losartan Isomer Dichloro Tetrazole
Losartan Impurity 5
Losartan Isomer azide tetrazole
Losartan Dichloro Tetrazole
Losartan Amine Impurity
Irbesartan Impurity 10
2-[4-(Aminomethyl)phenyl]benzoic Acid
2-[4-(Aminomethyl)phenyl]benzamide
(2-Butyl-4-chloro-1H-imidazol-5-yl) methanamine
4`-((5-(Aminomethyl)-2-butyl-4-chloro-1H-imidazol-1-yl)methyl)-[1,1`-biphenyl]-2-carbonitrile
4`-((4-(Aminomethyl)-2-butyl-5-chloro-1H-imidazol-1-yl)methyl)-[1,1`-biphenyl]-2-carbonitrile
Losartan Amine
Losartan Impurity 11
5-(Azidomethyl)-2-butyl-4-chloro-1H-imidazole
N-Trityl Losartan Isomer
4`-[(2-butyl-5-chloro-4-formyl-1H-imidazol-1-yl)methyl]biphenyl-2-carbonitrile
5-(azidomethyl)-2-butyl-4-chloro-1-((2`-isocyano-[1,1`-biphenyl]-4-yl)methyl)-1H-imidazole
4`-(Azidomethyl)-[1,1`-biphenyl]-3-carbonitrile
5-(4`-(azidomethyl)-[1,1`-biphenyl]-3-yl)-1H-tetrazole
(2-Butyl-4-chloro-1-((2`-(1-nitroso-1H-tetrazol-5-yl)-[1,1`-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)methanol
Nitroso Losartan Impurity
(2-Butyl-4-chloro-1-nitroso-1H-imidazol-5-yl)methanol
Deshydroxymethyl Losartan Trifluoroacetic Acid Salt
Trityl Losartan
N-Trityl Losartan Carboxaldehyde
Losartan EP Impurity C-Potassium Salt
Losartan Impurity 32
Losartan Impurity 33
Losartan Dimer Azide Impurity
4`-[(2-Butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]-[1,1`-Biphenyl]-2-carbonitrile
Olmesartan Impurity 47
Losartan Potassium Bromo analog
5-phenyl-2-trityl-2H-tetrazole
2,2`-bis(1-trityl-1H-tetrazol-5-yl)-1,1`-biphenyl
Losartan TTMB Impurity
Losartan Aldehyde Impurity
N-Trityl Losartan Isomer
1H-Imidazole-4-methanesulfonicacid,2-butyl-5-chloro-alpha-hydroxy
Losartan N-Oxide Impurity
Losartan Impurity 3
Losartan Impurity 4
Losartan Impurity 2
Losartan Impurity 6
Losartan Cum-Alcohol

Metabolites

Losartan N1-Glucuronide
Losartan N2-glucuronide
LosartanCarboxylicAcidAcyl-Beta-D-Glucuronide

Isotope Labelled Compounds

Losartan Carboxylic Acid-D4
Losartan-D4