Ivacaftor Related Compounds & Impurities

Ivacaftor is a CFTR potentiator that enhances chloride channel gating in specific CFTR mutations, used for cystic fibrosis.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Ivacaftor reference standards, pharmacopeial and non-pharmacopeial Ivacaftor impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Ivacaftor-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Ivacaftor Ethyl Ester Impurity
Ivacaftor Ethyl Ester Impurity
  • CAT. No.I130005
  • CAS. No.52980-28-6
  • Mol. F.C12H11NO3
  • Mol. W.217.22 g/mol
  • Stock Status:Instock
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Ivacaftor Acid Impurity
Ivacaftor Acid Impurity
  • CAT. No.I130006
  • CAS. No.13721-01-2
  • Mol. F.C10H7NO3
  • Mol. W.189.17 g/mol
  • Stock Status:Instock
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Ivacaftor
Ivacaftor
  • CAT. No.I150000
  • CAS. No.873054-44-5
  • Mol. F.C24H28N2O3
  • Mol. W.392.49 g/mol
  • Stock Status:Instock
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Hydroxymethyl Ivacaftor
Hydroxymethyl Ivacaftor
  • CAT. No.I150003
  • CAS. No.1246213-23-9
  • Mol. F.C24H28N2O4
  • Mol. W.408.49 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Carboxylic Acid
Ivacaftor Carboxylic Acid
  • CAT. No.I150004
  • CAS. No.1246213-24-0
  • Mol. F.C24H26N2O5
  • Mol. W.422.47 g/mol
  • Stock Status:Limited Stock
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Ivacaftor Amine Impurity
Ivacaftor Amine Impurity
  • CAT. No.I150005
  • CAS. No.873055-58-4
  • Mol. F.C14H23NO
  • Mol. W.221.34 g/mol
  • Stock Status:Instock
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6-Amino-2,4-di-tert-butylphenol
6-Amino-2,4-di-tert-butylphenol
  • CAT. No.I150008
  • CAS. No.1643-39-6
  • Mol. F.C14H23NO
  • Mol. W.221.34 g/mol
  • Stock Status:Instock
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Ivacaftor Ortho Isomer
Ivacaftor Ortho Isomer
  • CAT. No.I150010
  • CAS. No.873051-52-6
  • Mol. F.C24H28N2O3
  • Mol. W.392.49 g/mol
  • Stock Status:Instock
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N-Nitroso Ivacaftor
N-Nitroso Ivacaftor
  • CAT. No.I150011
  • CAS. No.NA
  • Mol. F.C24H27N3O4
  • Mol. W.421.50 g/mol
  • Stock Status:Under Synthesis
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N-Nitroso Ivacaftor Ortho Isomer
N-Nitroso Ivacaftor Ortho Isomer
  • CAT. No.I150012
  • CAS. No.NA
  • Mol. F.C24H27N3O4
  • Mol. W.421.49 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Quinoline Acid
N-Nitroso Quinoline Acid
  • CAT. No.I150013
  • CAS. No.NA
  • Mol. F.C10H6N2O4
  • Mol. W.218.17 g/mol
  • Stock Status:Under Synthesis
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N-Nitroso De-alkylated Ivacaftor
N-Nitroso De-alkylated Ivacaftor
  • CAT. No.I150014
  • CAS. No.NA
  • Mol. F.C20H19N3O4
  • Mol. W.365.38 g/mol
  • Stock Status:Limited Stock
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Ivacaftor Impurity 4
Ivacaftor Impurity 4
  • CAT. No.I150015
  • CAS. No.2760759-55-3
  • Mol. F.C34H33N3O5
  • Mol. W.563.64 g/mol
  • Stock Status:Instock
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De-Alkylated Ivacaftor
De-Alkylated Ivacaftor
  • CAT. No.I150016
  • CAS. No.873054-39-8
  • Mol. F.C20H20N2O3
  • Mol. W.336.38 g/mol
  • Stock Status:Under Synthesis
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Ivacaftor Nitroso Impurity 5
Ivacaftor Nitroso Impurity 5
  • CAT. No.I150017
  • CAS. No.NA
  • Mol. F.C14H16N2O5
  • Mol. W.292.29 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Nitroso Impurity 2
Ivacaftor Nitroso Impurity 2
  • CAT. No.I150018
  • CAS. No.NA
  • Mol. F.C12H10N2O3
  • Mol. W.230.22 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Nitroso Impurity 4
Ivacaftor Nitroso Impurity 4
  • CAT. No.I150019
  • CAS. No.NA
  • Mol. F.C9H6N2O2
  • Mol. W.174.16 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor O-beta-D-glucuronide
Ivacaftor O-beta-D-glucuronide
  • CAT. No.I150020
  • CAS. No.NA
  • Mol. F.C30H36N2O9
  • Mol. W.568.61 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 16
Ivacaftor Impurity 16
  • CAT. No.I150021
  • CAS. No.NA
  • Mol. F.C28H32N2O6
  • Mol. W.492.56 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Nitroso Impurity 6
Ivacaftor Nitroso Impurity 6
  • CAT. No.I150022
  • CAS. No.NA
  • Mol. F.C12H10N2O4
  • Mol. W.246.22 g/mol
  • Stock Status:Custom Synthesis
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4-Hydroxyquinoline-3-carboxylic acid
4-Hydroxyquinoline-3-carboxylic acid
  • CAT. No.I150023
  • CAS. No.34785-11-0
  • Mol. F.C10H7NO3
  • Mol. W.189.17 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 8
Ivacaftor Impurity 8
  • CAT. No.I150024
  • CAS. No.1182822-31-6
  • Mol. F.C16H25NO3
  • Mol. W.279.38 g/mol
  • Stock Status:Instock
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Ivacaftor Impurity 19
Ivacaftor Impurity 19
  • CAT. No.I150025
  • CAS. No.2760759-58-6
  • Mol. F.C24H28N2O3
  • Mol. W.392.49 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 11
Ivacaftor Impurity 11
  • CAT. No.I150026
  • CAS. No.NA
  • Mol. F.C24H27N2O4
  • Mol. W.407.48 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 1
Ivacaftor Impurity 1
  • CAT. No.I150027
  • CAS. No.54535-22-7
  • Mol. F.C14H17NO4
  • Mol. W.263.30 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 21
Ivacaftor Impurity 21
  • CAT. No.I150029
  • CAS. No.1623021-42-0
  • Mol. F.C16H22BrNO5
  • Mol. W.388.25 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 22
Ivacaftor Impurity 22
  • CAT. No.I150030
  • CAS. No.84210-35-5
  • Mol. F.C15H25NO
  • Mol. W.235.37 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 23
Ivacaftor Impurity 23
  • CAT. No.I150031
  • CAS. No.NA
  • Mol. F.C40H42N4O8
  • Mol. W.706.78 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 24
Ivacaftor Impurity 24
  • CAT. No.I150032
  • CAS. No.NA
  • Mol. F.C43H48N4O5
  • Mol. W.700.87 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 25
Ivacaftor Impurity 25
  • CAT. No.I150033
  • CAS. No.NA
  • Mol. F.C20H14N2O6
  • Mol. W.378.33 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 26
Ivacaftor Impurity 26
  • CAT. No.I150034
  • CAS. No.59238-67-4
  • Mol. F.C17H19NO
  • Mol. W.253.34 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 27
Ivacaftor Impurity 27
  • CAT. No.I150035
  • CAS. No.NA
  • Mol. F.C20H18N2O4
  • Mol. W.350.37 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 28
Ivacaftor Impurity 28
  • CAT. No.I150036
  • CAS. No.NA
  • Mol. F.C24H28N2O3
  • Mol. W.392.49 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 29
Ivacaftor Impurity 29
  • CAT. No.I150037
  • CAS. No.103914-79-0
  • Mol. F.C10H8N2O2
  • Mol. W.188.18 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor N-Glucuronide
Ivacaftor N-Glucuronide
  • CAT. No.I150038
  • CAS. No.NA
  • Mol. F.C30H36N2O9
  • Mol. W.568.61 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 30
Ivacaftor Impurity 30
  • CAT. No.I150039
  • CAS. No.NA
  • Mol. F.C24H28N2O5
  • Mol. W.424.49 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 20
Ivacaftor Impurity 20
  • CAT. No.I150040
  • CAS. No.NA
  • Mol. F.C20H18N2O4
  • Mol. W.350.37 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 31
Ivacaftor Impurity 31
  • CAT. No.I150041
  • CAS. No.873055-56-2
  • Mol. F.C16H23NO5
  • Mol. W.309.36 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 32
Ivacaftor Impurity 32
  • CAT. No.I150042
  • CAS. No.873055-54-0
  • Mol. F.C16H24O3
  • Mol. W.264.36 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 33
Ivacaftor Impurity 33
  • CAT. No.I150043
  • CAS. No.NA
  • Mol. F.C16H12N2O2
  • Mol. W.264.28 g/mol
  • Stock Status:Instock
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Ivacaftor Impurity 5
Ivacaftor Impurity 5
  • CAT. No.I150044
  • CAS. No.NA
  • Mol. F.C16H12N2O3
  • Mol. W.280.28 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 2
Ivacaftor Impurity 2
  • CAT. No.I150045
  • CAS. No.NA
  • Mol. F.C24H27N3O4
  • Mol. W.421.49 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Impurity 3
Ivacaftor Impurity 3
  • CAT. No.I150046
  • CAS. No.20039-94-5
  • Mol. F.C14H21NO3
  • Mol. W.251.30 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor Nitro phenol Impurity
Ivacaftor Nitro phenol Impurity
  • CAT. No.OT706820000
  • CAS. No.873055-57-3
  • Mol. F.C14H21NO3
  • Mol. W.251.32 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Ivacaftor-d18
Ivacaftor-d18
  • CAT. No.I150001
  • CAS. No.1413431-05-6
  • Mol. F.C24H10D18N2O3
  • Mol. W.410.6 g/mol
  • Stock Status:Custom Synthesis
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Ivacaftor D4
Ivacaftor D4
  • CAT. No.I150002
  • CAS. No.NA
  • Mol. F.C24H24D4N2O3
  • Mol. W.396.52 g/mol
  • Stock Status:Instock
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Ivacaftor D19
Ivacaftor D19
  • CAT. No.I150006
  • CAS. No.1413431-22-7
  • Mol. F.C24H9D19N2O3
  • Mol. W.411.61 g/mol
  • Stock Status:Under Synthesis
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Ivacaftor 13C6
Ivacaftor 13C6
  • CAT. No.I150007
  • CAS. No.NA
  • Mol. F.C1813C6H28N2O3
  • Mol. W.398.45 g/mol
  • Stock Status:Limited Stock
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Hydroxymethyl Ivacaftor D6
Hydroxymethyl Ivacaftor D6
  • CAT. No.I150028
  • CAS. No.NA
  • Mol. F.C24H22D6N2O4
  • Mol. W.414.53 g/mol
  • Stock Status:Custom Synthesis
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Deutivacaftor
Deutivacaftor
  • CAT. No.I150047
  • CAS. No.1413431-07-8
  • Mol. F.C24H19D9N2O3
  • Mol. W.401.50 g/mol
  • Stock Status:Please Enquire
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