Imatinib Related Compounds & Impurities

Imatinib is a BCR-ABL tyrosine kinase inhibitor that revolutionised chronic myeloid leukaemia treatment and is also used for gastrointestinal stromal tumours.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Imatinib reference standards, pharmacopeial and non-pharmacopeial Imatinib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Imatinib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Imatinib Mesylate
Imatinib Mesylate
  • CAT. No.I020000
  • CAS. No.220127-57-1
  • Mol. F.C29H31N7O.CH4O3S
  • Mol. W.589.71 g/mol
  • Stock Status:Instock
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Imatinib methanesulfonate Beta form
Imatinib methanesulfonate Beta form
  • CAT. No.I020000A
  • CAS. No.220127-57-1
  • Mol. F.C30H35N7O4S
  • Mol. W.589.71 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Mesyalte Impurity A
Imatinib Mesyalte Impurity A
  • CAT. No.I020001
  • CAS. No.571186-92-0
  • Mol. F.C29H31N7O2
  • Mol. W.509.25 g/ mol
  • Stock Status:Limited Stock
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N-Desmethyl Imatinib Impurity
N-Desmethyl Imatinib Impurity
  • CAT. No.I020002
  • CAS. No.404844-02-6
  • Mol. F.C28H29N7O
  • Mol. W.479.59 g/mol
  • Stock Status:Instock
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Imatinib Mesylate Impurity J
Imatinib Mesylate Impurity J
  • CAT. No.I020003
  • CAS. No.571186-91-9
  • Mol. F.C29H31N7O2
  • Mol. W.509.60 g/ mol
  • Stock Status:Instock
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Imatinib EP Impurity F
Imatinib EP Impurity F
  • CAT. No.I020004
  • CAS. No.152460-10-1
  • Mol. F.C16H15N5
  • Mol. W.277.32 g/mol
  • Stock Status:Instock
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N-DesmethylImatinib-D8
N-DesmethylImatinib-D8
  • CAT. No.I020005
  • CAS. No.1185103-28-9
  • Mol. F.C28H21D8ON7
  • Mol. W.487.63 g/mol
  • Stock Status:Instock
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Imatinib
Imatinib
  • CAT. No.I020006
  • CAS. No.152459-95-5
  • Mol. F.C29H31N7O
  • Mol. W.493.60 g/mol
  • Stock Status:Instock
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4-methylbenzamide
4-methylbenzamide
  • CAT. No.I020009
  • CAS. No.619-55-6
  • Mol. F.C8H9NO
  • Mol. W.135.16 g/ mol
  • Stock Status:Instock
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Imatinib EP Impurity F
Imatinib EP Impurity F
  • CAT. No.I020011
  • CAS. No.6515-58-8
  • Mol. F.C16H15N5
  • Mol. W.277.32 g/mol
  • Stock Status:Custom Synthesis
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3-[3-(Dimethylamino)acryloyl]pyridine
3-[3-(Dimethylamino)acryloyl]pyridine
  • CAT. No.I020012
  • CAS. No.55314-16-4
  • Mol. F.C10H12N2O
  • Mol. W.176.22 g/mol
  • Stock Status:Instock
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Imatinib Impurity ( Dimethyl amine Hydrochloride)
Imatinib Impurity ( Dimethyl amine Hydrochloride)
  • CAT. No.I020013
  • CAS. No.506-59-2
  • Mol. F.C2H8ClN
  • Mol. W.81.54 g/mol
  • Stock Status:Under Synthesis
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3-Acetylpyridine
3-Acetylpyridine
  • CAT. No.I020014
  • CAS. No.350-03-8
  • Mol. F.C7H7NO
  • Mol. W.121.14 g/mol
  • Stock Status:Instock
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Imatinib (Piperidine)-N,N-DiOxide
Imatinib (Piperidine)-N,N-DiOxide
  • CAT. No.I020015
  • CAS. No.571186-93-1
  • Mol. F.C29H31N7O3
  • Mol. W.525.60 g/mol
  • Stock Status:Instock
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Imatinib Diamine Impurity
Imatinib Diamine Impurity
  • CAT. No.I020016
  • CAS. No.152460-10-1
  • Mol. F.C16H15N5
  • Mol. W.277.30 g/mol
  • Stock Status:Custom Synthesis
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Imatinib impurity A
Imatinib impurity A
  • CAT. No.I020018
  • CAS. No.55314-16-4
  • Mol. F.C10H12N2O
  • Mol. W.176.22 g/mol
  • Stock Status:Custom Synthesis
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Imatinib EP Impurity B Hydrochloride
Imatinib EP Impurity B Hydrochloride
  • CAT. No.I020020
  • CAS. No.581076-65-5 (free base)
  • Mol. F.C21H28N6O.HCl
  • Mol. W.416.95 g/mol
  • Stock Status:Instock
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Imatinib EP Impurity D
Imatinib EP Impurity D
  • CAT. No.I020021
  • CAS. No.1821122-73-9
  • Mol. F.C53H51N12O2
  • Mol. W.888.05 g/mol
  • Stock Status:Under Synthesis
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Imatinib Carboxylic Impurity
Imatinib Carboxylic Impurity
  • CAT. No.I020022
  • CAS. No.106261-49-8
  • Mol. F.C13H20Cl2N2O2
  • Mol. W.307.22 g/mol
  • Stock Status:Instock
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4-((4-methylpiperazin-1-yl)methyl)benzoic acid Dihydrochloride
4-((4-methylpiperazin-1-yl)methyl)benzoic acid Dihydrochloride
  • CAT. No.I020022A
  • CAS. No.106261-49-8
  • Mol. F.C13H20Cl2N2O2
  • Mol. W.307.22 g/mol
  • Stock Status:Instock
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Imatinib Impurity 8
Imatinib Impurity 8
  • CAT. No.I020023
  • CAS. No.152459-96-6 (free base)
  • Mol. F.C24H21N5O.CH4O3S
  • Mol. W.491.56 g/mol
  • Stock Status:Instock
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Imatinib Mesylate impurity 02
Imatinib Mesylate impurity 02
  • CAT. No.I020024
  • CAS. No.NA
  • Mol. F.C25H25N5O4S
  • Mol. W.491.56 g/mol
  • Stock Status:Custom Synthesis
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O-Toluidine
O-Toluidine
  • CAT. No.I020025
  • CAS. No.95-53-4
  • Mol. F.C7H9N
  • Mol. W.107.16 g/mol
  • Stock Status:Instock
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p-Toluic acid
p-Toluic acid
  • CAT. No.I020026
  • CAS. No.99-94-5
  • Mol. F.C8H8O2
  • Mol. W.136.15 g/mol
  • Stock Status:Instock
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2-(chloromethyl)benzoic acid
2-(chloromethyl)benzoic acid
  • CAT. No.I020027
  • CAS. No.85888-81-9
  • Mol. F.C8H7ClO2
  • Mol. W.170.59 g/mol
  • Stock Status:Custom Synthesis
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2-[(4-methylpiperazin-1-yl)methyl]Benzonitrile
2-[(4-methylpiperazin-1-yl)methyl]Benzonitrile
  • CAT. No.I020028
  • CAS. No.864069-00-1
  • Mol. F.C13H17N3
  • Mol. W.215.29 g/ mol
  • Stock Status:Instock
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3-[(4-methylpiperazin-1-yl)methyl]Benzonitrile
3-[(4-methylpiperazin-1-yl)methyl]Benzonitrile
  • CAT. No.I020029
  • CAS. No.859850-90-1
  • Mol. F.C13H17N3
  • Mol. W.215.39 g/mol
  • Stock Status:Instock
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Imatinib Meta-Methyl-Piperazine Impurity
Imatinib Meta-Methyl-Piperazine Impurity
  • CAT. No.I020030
  • CAS. No.1246819-59-9
  • Mol. F.C29H31N7O
  • Mol. W.493.60 g/mol
  • Stock Status:Instock
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3-Bromomethylbenzonitrile
3-Bromomethylbenzonitrile
  • CAT. No.I020031
  • CAS. No.28188-41-2
  • Mol. F.C8H6BrN
  • Mol. W.196.04 g/mol
  • Stock Status:Instock
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Imatinib (Piperidine)-N4-Oxide
Imatinib (Piperidine)-N4-Oxide
  • CAT. No.I020033
  • CAS. No.938082-57-6
  • Mol. F.C29H31N7O2
  • Mol. W.509.60 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 2
Imatinib Impurity 2
  • CAT. No.I020035
  • CAS. No.796738-71-1
  • Mol. F.C16H13N5O2
  • Mol. W.307.31 g/mol
  • Stock Status:Instock
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3-((4-methylpiperazin-1-yl)methyl)benzoic Acid
3-((4-methylpiperazin-1-yl)methyl)benzoic Acid
  • CAT. No.I020036
  • CAS. No.541209-42-8
  • Mol. F.C13H18N2O2
  • Mol. W.234.29 g/mol
  • Stock Status:Instock
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Imatinib Impurity 3
Imatinib Impurity 3
  • CAT. No.I020037
  • CAS. No.152459-96-6
  • Mol. F.C24H21N5O
  • Mol. W.395.46 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 5
Imatinib Impurity 5
  • CAT. No.I020038
  • CAS. No.NA
  • Mol. F.C13H18N2O2
  • Mol. W.234.30 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 6
Imatinib Impurity 6
  • CAT. No.I020039
  • CAS. No.112696-91-0
  • Mol. F.C16H15N5
  • Mol. W.277.32 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 1
Imatinib Impurity 1
  • CAT. No.I020040
  • CAS. No.404844-11-7
  • Mol. F.C24H20ClN5O
  • Mol. W.429.90 g/mol
  • Stock Status:Instock
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Imatinib EP Impurity A
Imatinib EP Impurity A
  • CAT. No.I020041
  • CAS. No.123367-26-0
  • Mol. F.C10H12N2O
  • Mol. W.176.22 g/mol
  • Stock Status:Instock
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Imatinib (Piperidine)-N,N-DiOxide Methanesulfonate
Imatinib (Piperidine)-N,N-DiOxide Methanesulfonate
  • CAT. No.I020042
  • CAS. No.NA
  • Mol. F.C30H35N7O6S
  • Mol. W.621.71 g/mol
  • Stock Status:Custom Synthesis
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4-(Dichloromethyl)benzonitrile
4-(Dichloromethyl)benzonitrile
  • CAT. No.I020043
  • CAS. No.74231-65-5
  • Mol. F.C8H5Cl2N
  • Mol. W.186.04g/mol
  • Stock Status:Custom Synthesis
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Imatinib N-Acetyl Impurity
Imatinib N-Acetyl Impurity
  • CAT. No.I020044
  • CAS. No.1321600-78-5
  • Mol. F.C31H33N7O2
  • Mol. W.535.64 g/mol
  • Stock Status:Custom Synthesis
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N-Desmethyl Imatinib Mesylate
N-Desmethyl Imatinib Mesylate
  • CAT. No.I020045
  • CAS. No.404844-03-7
  • Mol. F.C29H33N7O4S
  • Mol. W.575.68 g/mol
  • Stock Status:Instock
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Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
Des(methylpiperazinyl-N-methyl) Imatinib Dimer Impurity
  • CAT. No.I020047
  • CAS. No.1365802-18-1
  • Mol. F.C52H48N12O2
  • Mol. W.873.04 g/mol
  • Stock Status:Instock
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Imatinib Dimer Impurity 1
Imatinib Dimer Impurity 1
  • CAT. No.I020051
  • CAS. No.NA
  • Mol. F.C33H28N10O
  • Mol. W.580.64 g/mol
  • Stock Status:Instock
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Imatinib EP Impurity C hydrochloride
Imatinib EP Impurity C hydrochloride
  • CAT. No.I020052
  • CAS. No.1820893-54-6
  • Mol. F.C28H30N7OCl
  • Mol. W.516.04 g/mol
  • Stock Status:Custom Synthesis
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1-(2-Methyl-5-nitrophenyl)guanidine nitrate
1-(2-Methyl-5-nitrophenyl)guanidine nitrate
  • CAT. No.I020053
  • CAS. No.152460-08-7
  • Mol. F.C8H11N5O5
  • Mol. W.257.2 g/mol
  • Stock Status:Instock
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2-Methyl-5-nitroaniline
2-Methyl-5-nitroaniline
  • CAT. No.I020054
  • CAS. No.99-55-8
  • Mol. F.C7H8N2O2
  • Mol. W.152.15 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Nitroso Impurity 2
Imatinib Nitroso Impurity 2
  • CAT. No.I020055
  • CAS. No.152460-09-8
  • Mol. F.C16H13N5O2
  • Mol. W.307.31 g/mol
  • Stock Status:Instock
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Imatinib EP Impurity G Diydrochloride
Imatinib EP Impurity G Diydrochloride
  • CAT. No.I020056
  • CAS. No.34352-59-5
  • Mol. F.C5H14N2Cl2
  • Mol. W.173.08 g/mol
  • Stock Status:Custom Synthesis
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1-(2-Methyl-5-nitrophenyl)biguanide
1-(2-Methyl-5-nitrophenyl)biguanide
  • CAT. No.I020057
  • CAS. No.NA
  • Mol. F.C9H12N6O2
  • Mol. W.236.23 g/mol
  • Stock Status:Custom Synthesis
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N-(2-Methyl-5-nitrophenyl)-N~-Carbamoyl Guanidine
N-(2-Methyl-5-nitrophenyl)-N~-Carbamoyl Guanidine
  • CAT. No.I020058
  • CAS. No.NA
  • Mol. F.C9H11N5O3
  • Mol. W.237.22 g/mol
  • Stock Status:Custom Synthesis
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(2-Methyl-4-nitrophenyl)guanidine
(2-Methyl-4-nitrophenyl)guanidine
  • CAT. No.I020059
  • CAS. No.796738-72-2
  • Mol. F.C8H10N4O2
  • Mol. W.194.19 g/mol
  • Stock Status:Custom Synthesis
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1-(2-Methyl-3-nitrophenyl)guanidine
1-(2-Methyl-3-nitrophenyl)guanidine
  • CAT. No.I020060
  • CAS. No.870459-88-4
  • Mol. F.C8H10N4O2
  • Mol. W.194.19 g/mol
  • Stock Status:Custom Synthesis
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N-nitroso Imatinib
N-nitroso Imatinib
  • CAT. No.I020061
  • CAS. No.NA
  • Mol. F.C29H30N8O2
  • Mol. W.522.60 g/mol
  • Stock Status:Custom Synthesis
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N-Desmethyl N-Nitroso Imatinib
N-Desmethyl N-Nitroso Imatinib
  • CAT. No.I020062
  • CAS. No.2816369-80-7
  • Mol. F.C28H28N8O2
  • Mol. W.508.57 g/mol
  • Stock Status:Instock
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N-Desmethyl-N-Nitroso Imatinib Impurity 1
N-Desmethyl-N-Nitroso Imatinib Impurity 1
  • CAT. No.I020063
  • CAS. No.NA
  • Mol. F.C28H28N8O2
  • Mol. W.508.57 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Mesylate Beta Form
Imatinib Mesylate Beta Form
  • CAT. No.I020064
  • CAS. No.NA
  • Mol. F.C30H35N7O4S
  • Mol. W.589.71 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Hydrochloride Impurity G
Imatinib Hydrochloride Impurity G
  • CAT. No.I020065
  • CAS. No.50398-09-9
  • Mol. F.C5H13ClN2
  • Mol. W.136.62 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Mesylate Impurity B
Imatinib Mesylate Impurity B
  • CAT. No.I020066
  • CAS. No.581076-65-5
  • Mol. F.C21H28N6O
  • Mol. W.380.49 g/mol
  • Stock Status:Instock
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(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one-hydrochloride
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one-hydrochloride
  • CAT. No.I020068
  • CAS. No.NA
  • Mol. F.C10H13ClN2O
  • Mol. W.212.68 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Mesylate Alpha Form
Imatinib Mesylate Alpha Form
  • CAT. No.I020069
  • CAS. No.NA
  • Mol. F.C30H35N7O4S
  • Mol. W.589.71 g/mol
  • Stock Status:Custom Synthesis
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Imatinib (Piperidine)-N,N-DiOxide Dimethanesulfonate
Imatinib (Piperidine)-N,N-DiOxide Dimethanesulfonate
  • CAT. No.I020070
  • CAS. No.NA
  • Mol. F.C29H31N7O3.2(CH4O3S)
  • Mol. W.717.81 g/mol
  • Stock Status:Instock
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Imatinib Mixture of N-oxide
Imatinib Mixture of N-oxide
  • CAT. No.I020071
  • CAS. No.NA
  • Mol. F.C58H62N14O4
  • Mol. W.1019.20 g/mol
  • Stock Status:Instock
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4-Chloromethyl Benzoic Acid
4-Chloromethyl Benzoic Acid
  • CAT. No.I020072
  • CAS. No.1642-81-5
  • Mol. F.C8H7ClO2
  • Mol. W.170.59 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 9
Imatinib Impurity 9
  • CAT. No.I020073
  • CAS. No.NA
  • Mol. F.C42H47N9O2
  • Mol. W.709.88 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 23
Imatinib Impurity 23
  • CAT. No.I020074
  • CAS. No.581076-66-6
  • Mol. F.C24H19Cl2N5O
  • Mol. W.464.35 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Impurity 4
Imatinib Impurity 4
  • CAT. No.I020075
  • CAS. No.NA
  • Mol. F.C17H16N4
  • Mol. W.276.34 g/mol
  • Stock Status:Custom Synthesis
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Imatinib EP Impurity D Trifluoroacetate
Imatinib EP Impurity D Trifluoroacetate
  • CAT. No.I020076
  • CAS. No.NA
  • Mol. F.C53H51N12O2.C2HF3O2
  • Mol. W.1002.07 g/mol
  • Stock Status:Instock
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Imatinib Impurity 7
Imatinib Impurity 7
  • CAT. No.I020077
  • CAS. No.NA
  • Mol. F.C16H13N5O2
  • Mol. W.307.31 g/mol
  • Stock Status:Instock
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Imatinib Nitroso Impurity 1
Imatinib Nitroso Impurity 1
  • CAT. No.I020078
  • CAS. No.NA
  • Mol. F.C16H12N6O3
  • Mol. W.336.30 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Nitroso Impurity 3
Imatinib Nitroso Impurity 3
  • CAT. No.I020079
  • CAS. No.NA
  • Mol. F.C16H14N6O
  • Mol. W.306.30 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Imatinib Metabolite AFN911
Imatinib Metabolite AFN911
  • CAT. No.I020048
  • CAS. No.NA
  • Mol. F.C29H33N7O2
  • Mol. W.511.62 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Metabolite CGP71422
Imatinib Metabolite CGP71422
  • CAT. No.I020049
  • CAS. No.NA
  • Mol. F.C29H31N7O2
  • Mol. W.509.60 g/mol
  • Stock Status:Custom Synthesis
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Imatinib Metabolite CGP72383
Imatinib Metabolite CGP72383
  • CAT. No.I020050
  • CAS. No.NA
  • Mol. F.C29H31N7O2
  • Mol. W.509.60 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Imatinib-D3
Imatinib-D3
  • CAT. No.I020007
  • CAS. No.1134803-18-1
  • Mol. F.C29H28D3N7O
  • Mol. W.496.62 g/mol
  • Stock Status:Instock
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Imatinib-D8
Imatinib-D8
  • CAT. No.I020008
  • CAS. No.1092942-82-9
  • Mol. F.C29H23N7OD8
  • Mol. W.501.65 g/mol
  • Stock Status:Instock
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Imatinib -D4
Imatinib -D4
  • CAT. No.I020032
  • CAS. No.1134803-16-9
  • Mol. F.C29H27D4N7O
  • Mol. W.497.63 g/mol
  • Stock Status:Under Synthesis
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2-Toluidine-d7
2-Toluidine-d7
  • CAT. No.I020046
  • CAS. No.68408-22-0
  • Mol. F.CHDN
  • Mol. W.114.2g/mol
  • Stock Status:Custom Synthesis
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N Desmethyl Imatinib-D4
N Desmethyl Imatinib-D4
  • CAT. No.I020067
  • CAS. No.NA
  • Mol. F.C28H25D4N7O
  • Mol. W.483.60 g/mol
  • Stock Status:Custom Synthesis
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