Fosaprepitant Related Compounds & Impurities

Fosaprepitant is the phosphoryl prodrug of aprepitant, an NK1 receptor antagonist, administered intravenously for chemotherapy-induced nausea and vomiting prevention.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Fosaprepitant reference standards, pharmacopeial and non-pharmacopeial Fosaprepitant impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Fosaprepitant-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Fosaprepitant Dimeglumine
Fosaprepitant Dimeglumine
  • CAT. No.F230000
  • CAS. No.265121-04-8
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Instock
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Fosaprepitant
Fosaprepitant
  • CAT. No.F230000A
  • CAS. No.172673-20-0
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Benzyl Ester
Fosaprepitant Benzyl Ester
  • CAT. No.F230001
  • CAS. No.889852-02-2
  • Mol. F.C30H28F7N4O6P
  • Mol. W.704.54 g/mol
  • Stock Status:Instock
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Fosaprepitant Dimeglumine Impurity A
Fosaprepitant Dimeglumine Impurity A
  • CAT. No.F230002
  • CAS. No.170902-81-5
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.44 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Impurity D
Fosaprepitant Dimeglumine Impurity D
  • CAT. No.F230003
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Impurity E
Fosaprepitant Dimeglumine Impurity E
  • CAT. No.F230004
  • CAS. No.NA
  • Mol. F.C23H23F6N4O6P.2(C7H17NO5)
  • Mol. W.986.84 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Stereochemical Impurity
Fosaprepitant Dimeglumine Stereochemical Impurity
  • CAT. No.F230005
  • CAS. No.NA
  • Mol. F.C37H56F7N6O16P
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Dibenzyl Phosaprepitant
Dibenzyl Phosaprepitant
  • CAT. No.F230006
  • CAS. No.265121-01-5
  • Mol. F.C35H34F7N4O6P
  • Mol. W.794.65 g/mol
  • Stock Status:Instock
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Fosaprepitant Ester Impurity
Fosaprepitant Ester Impurity
  • CAT. No.F230007
  • CAS. No.1803189-49-2
  • Mol. F.C24H25F7N4O4
  • Mol. W.566.47 g/mol
  • Stock Status:Limited Stock
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Fosaprepitant (R,R,R)-Isomer
Fosaprepitant (R,R,R)-Isomer
  • CAT. No.F230008
  • CAS. No.1523569-90-5
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Limited Stock
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Fosaprepitant Enantiomer
Fosaprepitant Enantiomer
  • CAT. No.F230009
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P.2(C14H34O1
  • Mol. W.1004.83 g/mol
  • Stock Status:Instock
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Dibenzyl Phosphate Impurity
Dibenzyl Phosphate Impurity
  • CAT. No.F230010
  • CAS. No.1623-08-1
  • Mol. F.C14H15O4P
  • Mol. W.278.24 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Desfluoro Impurity
Fosaprepitant Desfluoro Impurity
  • CAT. No.F230011
  • CAS. No.NA
  • Mol. F.C23H23F6N4O6P
  • Mol. W.596.42 g/mol
  • Stock Status:Under Synthesis
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Fosaprepitant Dimeglumine Impurity F
Fosaprepitant Dimeglumine Impurity F
  • CAT. No.F230012
  • CAS. No.2035475-10-4
  • Mol. F.C30H28F7N4O6P
  • Mol. W.704.53 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity B
Fosaprepitant Impurity B
  • CAT. No.F230013
  • CAS. No.NA
  • Mol. F.C24H25F7N4O4
  • Mol. W.566.47 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Impurity C
Fosaprepitant Dimeglumine Impurity C
  • CAT. No.F230014
  • CAS. No.170729-80-3
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 10
Fosaprepitant Impurity 10
  • CAT. No.F230015
  • CAS. No.172673-19-7
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dibenzyl Ester
Fosaprepitant Dibenzyl Ester
  • CAT. No.F230016
  • CAS. No.265121-01-5
  • Mol. F.C37H34F7N4O6P
  • Mol. W.794.65 g/mol
  • Stock Status:Instock
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Fosaprepitant Diastereomer Impurity
Fosaprepitant Diastereomer Impurity
  • CAT. No.F230017
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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3-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl((2S,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-(methylamino)hexan-2-yl)hydrogen phosphate
3-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl((2S,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-(methylamino)hexan-2-yl)hydrogen phosphate
  • CAT. No.F230018
  • CAS. No.NA
  • Mol. F.C30H37F7N5O11P
  • Mol. W.807.60 g/mol
  • Stock Status:Custom Synthesis
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(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
  • CAT. No.F230019
  • CAS. No.171482-05-6
  • Mol. F.C20H19ClF7NO2
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine N-Oxide Impurity
Fosaprepitant Dimeglumine N-Oxide Impurity
  • CAT. No.F230020
  • CAS. No.NA
  • Mol. F.C23H22F7N4O7P.C14H34N2
  • Mol. W.1029.32 g/mol
  • Stock Status:Instock
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(3-(((2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
(3-(((2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
  • CAT. No.F230021
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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(3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
(3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
  • CAT. No.F230022
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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(3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
(3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
  • CAT. No.F230023
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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(3-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
(3-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
  • CAT. No.F230024
  • CAS. No.172822-01-4
  • Mol. F.C23H22F7N4O6P
  • Mol. W.614.41 g/mol
  • Stock Status:Custom Synthesis
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(3-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acidDimegluminesalt)-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonicacidDimeglumine salt)
(3-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acidDimegluminesalt)-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonicacidDimeglumine salt)
  • CAT. No.F230025
  • CAS. No.NA
  • Mol. F.C37H56F7N6O16P
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Impurity D
Fosaprepitant Dimeglumine Impurity D
  • CAT. No.F230026
  • CAS. No.NA
  • Mol. F.C37H56F7N6O16P
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Des Fluoro Impurity Dimeglumine Salt
Fosaprepitant Des Fluoro Impurity Dimeglumine Salt
  • CAT. No.F230027
  • CAS. No.NA
  • Mol. F.C37H57F6N6O16P
  • Mol. W.986.84 g/mol
  • Stock Status:Instock
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(3-(((2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid dimeglumine(2:1) (salt)
(3-(((2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid dimeglumine(2:1) (salt)
  • CAT. No.F230029
  • CAS. No.NA
  • Mol. F.C37H56F7N6O16P
  • Mol. W.1004.83 g/mol
  • Stock Status:Limited Stock
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Fosaprepitant Impurity 1
Fosaprepitant Impurity 1
  • CAT. No.F230030
  • CAS. No.NA
  • Mol. F.C44H62F7N6O16P
  • Mol. W.1094.96 g/mol
  • Stock Status:Instock
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Fosaprepitant Diastereomer SSR Dimeglumine Salt
Fosaprepitant Diastereomer SSR Dimeglumine Salt
  • CAT. No.F230031
  • CAS. No.NA
  • Mol. F.C37H56F7N6O16P
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 2
Fosaprepitant Impurity 2
  • CAT. No.F230032
  • CAS. No.1523569-87-0
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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(2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine Hydrochloride
(2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine Hydrochloride
  • CAT. No.F230034
  • CAS. No.1333995-14-4
  • Mol. F.C20H19ClF7NO2
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 17
Fosaprepitant Impurity 17
  • CAT. No.F230035
  • CAS. No.NA
  • Mol. F.C22H19F7N4O3
  • Mol. W.520.40 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 18
Fosaprepitant Impurity 18
  • CAT. No.F230036
  • CAS. No.NA
  • Mol. F.C30H28F7N4O7P
  • Mol. W.720.53 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 8
Fosaprepitant Impurity 8
  • CAT. No.F230037
  • CAS. No.NA
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 20
Fosaprepitant Impurity 20
  • CAT. No.F230038
  • CAS. No.NA
  • Mol. F.C23H22F7N4O7P
  • Mol. W.630.41 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 3
Fosaprepitant Impurity 3
  • CAT. No.F230039
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.809.62 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Meglumine Impurity
Fosaprepitant Meglumine Impurity
  • CAT. No.F230040
  • CAS. No.NA
  • Mol. F.C30H28F7N4O6P.C7H17NO5
  • Mol. W.898.74 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant N-phosphoryl impurity
Fosaprepitant N-phosphoryl impurity
  • CAT. No.F230041
  • CAS. No.NA
  • Mol. F.C23H23F7N4O9P2
  • Mol. W.694.39 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant O-phosphoryl impurity
Fosaprepitant O-phosphoryl impurity
  • CAT. No.F230042
  • CAS. No.NA
  • Mol. F.C23H23F7N4O9P2
  • Mol. W.694.40 g/mol
  • Stock Status:Custom Synthesis
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(1`S,2R,3S)-Fosaprepitant Dimeglumine
(1`S,2R,3S)-Fosaprepitant Dimeglumine
  • CAT. No.F230043
  • CAS. No.NA
  • Mol. F.C23H22F7N4O6P.2(C7H17NO5)
  • Mol. W.1004.83 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Dimeglumine Impurity F (Dimeglumine)
Fosaprepitant Dimeglumine Impurity F (Dimeglumine)
  • CAT. No.F230044
  • CAS. No.2035475-11-5
  • Mol. F.C30H26F7N4O6P.C7H18NO5
  • Mol. W.899.74 g/mol
  • Stock Status:Custom Synthesis
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Fosaprepitant Impurity 4
Fosaprepitant Impurity 4
  • CAT. No.F230045
  • CAS. No.2315504-34-6
  • Mol. F.C16H12FN3O3
  • Mol. W.313.30 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Fosaprepitant-D4 Dimeglumine
Fosaprepitant-D4 Dimeglumine
  • CAT. No.F230028
  • CAS. No.265121-04-8(un-labelled)
  • Mol. F.C37H52D4F7N6O16P
  • Mol. W.1008.86 g/mol
  • Stock Status:Custom Synthesis
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