Erlotinib Related Compounds & Impurities

Erlotinib is a reversible EGFR tyrosine kinase inhibitor used for EGFR mutation-positive non-small cell lung cancer and pancreatic cancer.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Erlotinib reference standards, pharmacopeial and non-pharmacopeial Erlotinib impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Erlotinib-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Erlotinib Hydrochloride
Erlotinib Hydrochloride
  • CAT. No.E240000
  • CAS. No.183319-69-9
  • Mol. F.C22H23N3O4.HCl
  • Mol. W.429.90 g/mol
  • Stock Status:Instock
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Erlotinib
Erlotinib
  • CAT. No.E240001
  • CAS. No.183321-74-6
  • Mol. F.C22H23N3O4
  • Mol. W.393.44 g/mol
  • Stock Status:Instock
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Erlotinib Impurity-(3-Ethynylaniline)
Erlotinib Impurity-(3-Ethynylaniline)
  • CAT. No.E240003
  • CAS. No.54060-30-9
  • Mol. F.C8H7N
  • Mol. W.117.15 g/mol
  • Stock Status:Instock
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Erlotinib Chloro Impurity
Erlotinib Chloro Impurity
  • CAT. No.E240004
  • CAS. No.183322-18-1
  • Mol. F.C14H17ClN2O4
  • Mol. W.312.75 g/mol
  • Stock Status:Instock
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Erlotinib Hydrochloride Impurity 3
Erlotinib Hydrochloride Impurity 3
  • CAT. No.E240007
  • CAS. No.1145671-52-8
  • Mol. F.C20H23N3O4
  • Mol. W.369.42 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 8
Erlotinib Impurity 8
  • CAT. No.E240008
  • CAS. No.328528-74-1
  • Mol. F.C20H22BrN3O4
  • Mol. W.448.31 g/mol
  • Stock Status:Instock
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Erlotinib Impurity M
Erlotinib Impurity M
  • CAT. No.E240009
  • CAS. No.183322-21-6
  • Mol. F.C12H11Cl3N2O2
  • Mol. W.321.59 g/mol
  • Stock Status:Instock
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1-(3-Aminophenyl)ethanone
1-(3-Aminophenyl)ethanone
  • CAT. No.E240010
  • CAS. No.99-03-6
  • Mol. F.C8H9NO
  • Mol. W.135.16 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 27
Erlotinib Impurity 27
  • CAT. No.E240011
  • CAS. No.183322-16-9
  • Mol. F.C15H22O6
  • Mol. W.298.34 g/mol
  • Stock Status:Instock
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Erlotinib Lactam Impurity
Erlotinib Lactam Impurity
  • CAT. No.E240012
  • CAS. No.179688-29-0
  • Mol. F.C14H18N2O5
  • Mol. W.294.30 g/mol
  • Stock Status:Instock
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Erlotinib Impurity D
Erlotinib Impurity D
  • CAT. No.E240015
  • CAS. No.3943-89-3
  • Mol. F.C9H10O4
  • Mol. W.182.17 g/mol
  • Stock Status:Instock
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Erlotinib impurity E
Erlotinib impurity E
  • CAT. No.E240016
  • CAS. No.179688-27-8
  • Mol. F.C15H23NO6
  • Mol. W.313.35 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 11
Erlotinib Impurity 11
  • CAT. No.E240017
  • CAS. No.179688-26-7
  • Mol. F.C15H21NO8
  • Mol. W.343.33 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 18
Erlotinib Impurity 18
  • CAT. No.E240018
  • CAS. No.236750-62-2
  • Mol. F.C13H20N2O5
  • Mol. W.284.31 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 2
Erlotinib Impurity 2
  • CAT. No.E240019
  • CAS. No.54060-30-9
  • Mol. F.C8H7N
  • Mol. W.117.15 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 14
Erlotinib Impurity 14
  • CAT. No.E240020
  • CAS. No.950596-59-5
  • Mol. F.C16H23N3O4
  • Mol. W.321.37 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 23
Erlotinib Impurity 23
  • CAT. No.E240021
  • CAS. No.1417161-98-8
  • Mol. F.C14H19N3O4
  • Mol. W.293.32 g/mol
  • Stock Status:Custom Synthesis
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Didesmethyl Erlotinib Hydrochloride Salt
Didesmethyl Erlotinib Hydrochloride Salt
  • CAT. No.E240022
  • CAS. No.183320-12-9
  • Mol. F.C20H20ClN3O4
  • Mol. W.401.84 g/mol
  • Stock Status:Custom Synthesis
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N-Methoxyethyl Erlotinib Hydrochloride
N-Methoxyethyl Erlotinib Hydrochloride
  • CAT. No.E240023
  • CAS. No.2410548-58-0 (Free base)
  • Mol. F.C25H29N3O5.HCl
  • Mol. W.487.98 g/mol
  • Stock Status:Instock
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N-Methoxyethyl Erlotinib
N-Methoxyethyl Erlotinib
  • CAT. No.E240023A
  • CAS. No.2410548-58-0
  • Mol. F.C25H29N3O5
  • Mol. W.451.52 g/mol
  • Stock Status:Instock
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3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
3-butyn-2-ol, 4-[3-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amine]phenyl]-2-methyl, hydrochloride
  • CAT. No.E240025
  • CAS. No.299912-59-7
  • Mol. F.C25H30ClN3O5
  • Mol. W.487.97 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Isopropyl Ether
Erlotinib Isopropyl Ether
  • CAT. No.E240026
  • CAS. No.1683583-39-2
  • Mol. F.C17H24N2O5
  • Mol. W.336.38 g/mol
  • Stock Status:Instock
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3-Bromo-Erlotinib Hydrochloride
3-Bromo-Erlotinib Hydrochloride
  • CAT. No.E240027
  • CAS. No.2055840-41-8
  • Mol. F.C22H22BrN3O4.HCl
  • Mol. W.448.31 g/mol
  • Stock Status:Instock
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Erlotinib Dimer 2
Erlotinib Dimer 2
  • CAT. No.E240028
  • CAS. No.NA
  • Mol. F.C28H34N4O9
  • Mol. W.570.59 g/mol
  • Stock Status:Limited Stock
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Erlotinib Chloroethene Impurity Hydrochloride
Erlotinib Chloroethene Impurity Hydrochloride
  • CAT. No.E240029
  • CAS. No.2204518-92-1(free base)
  • Mol. F.C22H25Cl2N3O4
  • Mol. W.466.36 g/mol
  • Stock Status:Instock
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ethyl2-amino-4-(2-hydroxyethoxy)-5-(2-methoxyethoxy)benzoate-
ethyl2-amino-4-(2-hydroxyethoxy)-5-(2-methoxyethoxy)benzoate-
  • CAT. No.E240033
  • CAS. No.NA
  • Mol. F.C14H21NO6
  • Mol. W.299.32 g/mol
  • Stock Status:Custom Synthesis
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ethyl2-amino-5-(2-hydroxyethoxy)-4-(2-methoxyethoxy)benzoate
ethyl2-amino-5-(2-hydroxyethoxy)-4-(2-methoxyethoxy)benzoate
  • CAT. No.E240034
  • CAS. No.NA
  • Mol. F.C14H21NO6
  • Mol. W.299.32 g/mol
  • Stock Status:Custom Synthesis
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2-Ethynylaniline
2-Ethynylaniline
  • CAT. No.E240035
  • CAS. No.52670-38-9
  • Mol. F.C8H7N
  • Mol. W.117.20 g/mol
  • Stock Status:Custom Synthesis
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4-Ethynylaniline
4-Ethynylaniline
  • CAT. No.E240036
  • CAS. No.14235-81-5
  • Mol. F.C8H7N
  • Mol. W.117.15 g/mol
  • Stock Status:Custom Synthesis
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2-((4-amino-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
2-((4-amino-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
  • CAT. No.E240037
  • CAS. No.1839513-98-2
  • Mol. F.C13H17N3O4
  • Mol. W.279.29 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 35
Erlotinib Impurity 35
  • CAT. No.E240038
  • CAS. No.1354727-63-1
  • Mol. F.C22H25N3O5
  • Mol. W.411.45 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Chloroethene Impurity
Erlotinib Chloroethene Impurity
  • CAT. No.E240039
  • CAS. No.2204518-92-1
  • Mol. F.C22H24ClN3O4
  • Mol. W.429.90 g/mol
  • Stock Status:Custom Synthesis
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Desmethyl Erlotinib
Desmethyl Erlotinib
  • CAT. No.E240040
  • CAS. No.183321-86-0
  • Mol. F.C21H21N3O4
  • Mol. W.379.41 g/mol
  • Stock Status:Custom Synthesis
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7-(2`-Desmethyl) Erlotinib
7-(2`-Desmethyl) Erlotinib
  • CAT. No.E240041
  • CAS. No.183320-29-8
  • Mol. F.C21H21N3O4
  • Mol. W.379.41 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 4
Erlotinib Impurity 4
  • CAT. No.E240042
  • CAS. No.183321-83-7
  • Mol. F.C21H20ClN3O3
  • Mol. W.397.85 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib 7-O-Chloroethyl Analog
Erlotinib 7-O-Chloroethyl Analog
  • CAT. No.E240043
  • CAS. No.183321-85-9
  • Mol. F.C21H20ClN3O3
  • Mol. W.397.85 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 1
Erlotinib Impurity 1
  • CAT. No.E240046
  • CAS. No.1710372-46-5
  • Mol. F.C14H16Cl2N2O4
  • Mol. W.347.19 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 2
Erlotinib Impurity 2
  • CAT. No.E240047
  • CAS. No.183322-19-2
  • Mol. F.C13H14Cl2N2O3
  • Mol. W.317.17 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib-3-Vinyl Hydrochloride
Erlotinib-3-Vinyl Hydrochloride
  • CAT. No.E240048
  • CAS. No.1624294-38-7
  • Mol. F.C22H25N3O4.HCl
  • Mol. W.431.91 g/mol
  • Stock Status:Custom Synthesis
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Desmethyl Erlotinib Acetate
Desmethyl Erlotinib Acetate
  • CAT. No.E240049
  • CAS. No.183320-15-2
  • Mol. F.C23H23N3O5
  • Mol. W.421.45 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib
Erlotinib
  • CAT. No.E240050
  • CAS. No.183321-74-6
  • Mol. F.C22H23N3O4
  • Mol. W.393.44 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 33
Erlotinib Impurity 33
  • CAT. No.E240051
  • CAS. No.1839513-98-2
  • Mol. F.C13H17N3O4
  • Mol. W.279.29 g/mol
  • Stock Status:Custom Synthesis
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7-O-Desmethoxy-7-O-chloroethyl Erlotinib
7-O-Desmethoxy-7-O-chloroethyl Erlotinib
  • CAT. No.E240052
  • CAS. No.183321-85-9
  • Mol. F.C21H20ClN3O3
  • Mol. W.397.85 g/mol
  • Stock Status:Custom Synthesis
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3-Ethynylaniline hydrochloride
3-Ethynylaniline hydrochloride
  • CAT. No.E240053
  • CAS. No.207226-02-6
  • Mol. F.C8H7N.HCl
  • Mol. W.153.61 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Amine Impurity
Erlotinib Amine Impurity
  • CAT. No.E240054
  • CAS. No.NA
  • Mol. F.NA
  • Mol. W.NA
  • Stock Status:Custom Synthesis
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4-Methyl Erlotinib
4-Methyl Erlotinib
  • CAT. No.E240055
  • CAS. No.1346601-52-2
  • Mol. F.C23H25N3O4
  • Mol. W.407.46 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 5
Erlotinib Impurity 5
  • CAT. No.E240060
  • CAS. No.2596073-36-6
  • Mol. F.C22H23N3O5
  • Mol. W.409.44 g/mol
  • Stock Status:Instock
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4-(3-Aminophenyl)-2-methylbutan-2-ol
4-(3-Aminophenyl)-2-methylbutan-2-ol
  • CAT. No.E240061
  • CAS. No.69936-71-6
  • Mol. F.C11H17NO
  • Mol. W.179.26 g/mol
  • Stock Status:Custom Synthesis
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N-(4-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
N-(4-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
  • CAT. No.E240062
  • CAS. No.1029721-32-1
  • Mol. F.C22H23N3O4
  • Mol. W.393.44 g/mol
  • Stock Status:Custom Synthesis
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N-(2-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
N-(2-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
  • CAT. No.E240063
  • CAS. No.NA
  • Mol. F.C22H23N3O4
  • Mol. W.393.44 g/mol
  • Stock Status:Instock
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Tetrahydro Erlotinib
Tetrahydro Erlotinib
  • CAT. No.E240064
  • CAS. No.299912-61-1
  • Mol. F.C22H27N3O4
  • Mol. W.397.47 g/mol
  • Stock Status:Instock
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4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-2-methylbutan-2-ol
4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-2-methylbutan-2-ol
  • CAT. No.E240065
  • CAS. No.NA
  • Mol. F.C25H33N3O5
  • Mol. W.455.55 g/mol
  • Stock Status:Custom Synthesis
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4-(3-Aminophenyl)-2-methylbutan-2-ol
4-(3-Aminophenyl)-2-methylbutan-2-ol
  • CAT. No.E240066
  • CAS. No.69936-71-6
  • Mol. F.C11H17NO
  • Mol. W.179.26 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 10
Erlotinib Impurity 10
  • CAT. No.E240067
  • CAS. No.183322-17-0
  • Mol. F.C15H23NO6.HCl
  • Mol. W.349.81 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity C
Erlotinib Impurity C
  • CAT. No.E240068
  • CAS. No.1312937-41-9
  • Mol. F.C15H20N2O5
  • Mol. W.308.33 g/mol
  • Stock Status:Instock
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Erlotinib Impurity F
Erlotinib Impurity F
  • CAT. No.E240070
  • CAS. No.1809951-10-7
  • Mol. F.C28H34N4O9
  • Mol. W.570.59 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 6
Erlotinib Impurity 6
  • CAT. No.E240071
  • CAS. No.183321-82-6
  • Mol. F.C20H17Cl2N3O2
  • Mol. W.402.27 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 13
Erlotinib Impurity 13
  • CAT. No.E240072
  • CAS. No.183322-20-5
  • Mol. F.C13H14Cl2N2O3
  • Mol. W.317.17 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Hydrochloride Form-B
Erlotinib Hydrochloride Form-B
  • CAT. No.E240073
  • CAS. No.183319-69-9
  • Mol. F.C22H24ClN3O4
  • Mol. W.429.90 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Nitroso Impurity
Erlotinib Nitroso Impurity
  • CAT. No.E240074
  • CAS. No.NA
  • Mol. F.C22H22N4O5
  • Mol. W.422.43 g/mol
  • Stock Status:Custom Synthesis
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6,7-Bis(2-Methoxyethoxy)-N-(3-ethylphenyl)-N-(2-methoxyethyl)quinazolin-4-amine
6,7-Bis(2-Methoxyethoxy)-N-(3-ethylphenyl)-N-(2-methoxyethyl)quinazolin-4-amine
  • CAT. No.E240075
  • CAS. No.NA
  • Mol. F.C25H33N3O5
  • Mol. W.455.55 g/mol
  • Stock Status:Custom Synthesis
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3-Vinyl Erlotinib
3-Vinyl Erlotinib
  • CAT. No.E240077
  • CAS. No.1058132-82-3
  • Mol. F.C22H25N3O4
  • Mol. W.395.45 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 31
Erlotinib Impurity 31
  • CAT. No.E240078
  • CAS. No.183320-24-3
  • Mol. F.C23H23N3O5
  • Mol. W.421.45 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Acetate
Erlotinib Acetate
  • CAT. No.E240079
  • CAS. No.2055840-54-3
  • Mol. F.C24H25N3O5
  • Mol. W.435.47 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 52
Erlotinib Impurity 52
  • CAT. No.E240080
  • CAS. No.1683583-42-7
  • Mol. F.C18H26N2O5
  • Mol. W.350.41 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 1 Hydrochloride Salt
Erlotinib Impurity 1 Hydrochloride Salt
  • CAT. No.E240081
  • CAS. No.NA
  • Mol. F.C13H14Cl2N2O3.HCl
  • Mol. W.353.63 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 7
Erlotinib Impurity 7
  • CAT. No.E240082
  • CAS. No.69088-96-6
  • Mol. F.C11H13NO
  • Mol. W.175.23 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Impurity 9 Hydrochloride
Erlotinib Impurity 9 Hydrochloride
  • CAT. No.E240083
  • CAS. No.2055840-53-2
  • Mol. F.C20H23N3O4.HCl
  • Mol. W.405.88 g/mol
  • Stock Status:Instock
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Erlotinib Impurity 12
Erlotinib Impurity 12
  • CAT. No.E240084
  • CAS. No.15411-43-5
  • Mol. F.C8H9N
  • Mol. W.119.20 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Erlotinib O-Desmethyl Metabolite Isomer
Erlotinib O-Desmethyl Metabolite Isomer
  • CAT. No.E240005
  • CAS. No.183320-29-8
  • Mol. F.C21H21N3O4
  • Mol. W.379.42 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Didesmethyl
Erlotinib Didesmethyl
  • CAT. No.E240022A
  • CAS. No.183321-84-8
  • Mol. F.C20H19N3O4
  • Mol. W.365.38 g/mol
  • Stock Status:Instock
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Erlotinib Hydroxy Metabolite
Erlotinib Hydroxy Metabolite
  • CAT. No.E240058
  • CAS. No.882420-22-6
  • Mol. F.C22H23N3O5
  • Mol. W.409.44 g/mol
  • Stock Status:Custom Synthesis
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Erlotinib Carboxylic Acid
Erlotinib Carboxylic Acid
  • CAT. No.E240076
  • CAS. No.882420-21-5
  • Mol. F.C22H25N3O6
  • Mol. W.427.45 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Erlotinib-D6 Hydrochloride
Erlotinib-D6 Hydrochloride
  • CAT. No.E240002
  • CAS. No.1189953-78-3
  • Mol. F.C22H18D6ClN3O4
  • Mol. W.435.93 g/mol
  • Stock Status:Limited Stock
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Erlotinib 13C6 Hydrochloride
Erlotinib 13C6 Hydrochloride
  • CAT. No.E240014
  • CAS. No.1210610-07-3
  • Mol. F.C1613C6H23N3O4HCl
  • Mol. W.435.82 g/mol
  • Stock Status:Custom Synthesis
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3-Ethynylaniline-D4
3-Ethynylaniline-D4
  • CAT. No.E240069
  • CAS. No.1794883-73-0
  • Mol. F.C8H3D4N
  • Mol. W.121.17 g/mol
  • Stock Status:Custom Synthesis
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