Efinaconazole Related Compounds & Impurities

Efinaconazole is a triazole antifungal that inhibits ergosterol biosynthesis, formulated as a 10% topical solution for toenail onychomycosis.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Efinaconazole reference standards, pharmacopeial and non-pharmacopeial Efinaconazole impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Efinaconazole-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Efinaconazole
Efinaconazole
  • CAT. No.E620000
  • CAS. No.164650-44-6
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Instock
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Efinaconazole (2S,3R) Epoxide
Efinaconazole (2S,3R) Epoxide
  • CAT. No.E620001
  • CAS. No.135270-07-4
  • Mol. F.C12H11F2N3O
  • Mol. W.251.24 g/mol
  • Stock Status:Custom Synthesis
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Enatiomer of Efinaconazole
Enatiomer of Efinaconazole
  • CAT. No.E620002
  • CAS. No.164650-45-7
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Instock
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(R,R)-Efinaconazole Epoxide
(R,R)-Efinaconazole Epoxide
  • CAT. No.E620003
  • CAS. No.135270-13-2
  • Mol. F.C12H11F2N3O
  • Mol. W.251.23 g/mol
  • Stock Status:Custom Synthesis
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(S,S)-Efinaconazole Epoxide
(S,S)-Efinaconazole Epoxide
  • CAT. No.E620004
  • CAS. No.135270-10-9
  • Mol. F.C12H11F2N3O
  • Mol. W.251.23 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity A7
Efinaconazole Impurity A7
  • CAT. No.E620005
  • CAS. No.135270-05-2
  • Mol. F.C12H13F2N3O2
  • Mol. W.269.25 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 4
Efinaconazole Impurity 4
  • CAT. No.E620006
  • CAS. No.135270-11-0
  • Mol. F.C12H13F2N3O2
  • Mol. W.269.25 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 1
Efinaconazole Impurity 1
  • CAT. No.E620007
  • CAS. No.135272-36-5
  • Mol. F.C12H13F2N3O2
  • Mol. W.269.25 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 27
Efinaconazole Impurity 27
  • CAT. No.E620008
  • CAS. No.136081-74-8
  • Mol. F.C15H19NO3
  • Mol. W.261.32 g/mol
  • Stock Status:Instock
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Efinaconazole Impurity 3
Efinaconazole Impurity 3
  • CAT. No.E620009
  • CAS. No.19980-00-8
  • Mol. F.C13H17NO2
  • Mol. W.219.28 g/mol
  • Stock Status:Instock
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Efinaconazole Impurity 28
Efinaconazole Impurity 28
  • CAT. No.E620010
  • CAS. No.63608-15-1
  • Mol. F.C13H16ClNO
  • Mol. W.237.72 g/mol
  • Stock Status:Instock
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Effinaconazole Methylene Methanone Impurity
Effinaconazole Methylene Methanone Impurity
  • CAT. No.E620011
  • CAS. No.188904-84-9
  • Mol. F.C13H15NO
  • Mol. W.201.26g/mol
  • Stock Status:Instock
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4-methylenepiperidine
4-methylenepiperidine
  • CAT. No.E620012
  • CAS. No.148133-82-8
  • Mol. F.C6H11N
  • Mol. W.97.16 g/mol
  • Stock Status:Custom Synthesis
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Effinaconazole Methylene Impurity
Effinaconazole Methylene Impurity
  • CAT. No.E620012A
  • CAS. No.144230-50-2
  • Mol. F.C6H12ClN
  • Mol. W.133.6 g/mol
  • Stock Status:Instock
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(2R,3S)-Efinaconazole
(2R,3S)-Efinaconazole
  • CAT. No.E620013
  • CAS. No.2055038-60-1
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Instock
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(2S,3R)-Efinaconazole
(2S,3R)-Efinaconazole
  • CAT. No.E620014
  • CAS. No.2055038-61-2
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Instock
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Efinaconazole Impurity 9
Efinaconazole Impurity 9
  • CAT. No.E620015
  • CAS. No.1175536-50-1
  • Mol. F.C13H17F2N3O5S
  • Mol. W.365.35 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole N-Oxide
Efinaconazole N-Oxide
  • CAT. No.E620017
  • CAS. No.2055038-63-4
  • Mol. F.C18H22F2N4O2
  • Mol. W.364.40 g/mol
  • Stock Status:Instock
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Efinaconazole Diol Impurity
Efinaconazole Diol Impurity
  • CAT. No.E620018
  • CAS. No.133775-25-4
  • Mol. F.C12H13F2N3O2
  • Mol. W.269.25 g/mol
  • Stock Status:Instock
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Adipic acid, propyl 2-propyl ester
Adipic acid, propyl 2-propyl ester
  • CAT. No.E620019
  • CAS. No.NA
  • Mol. F.C12H22O4
  • Mol. W.230.30 g/mol
  • Stock Status:Custom Synthesis
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Methoxyacetic Acid, Dodecyl Ester
Methoxyacetic Acid, Dodecyl Ester
  • CAT. No.E620020
  • CAS. No.959247-28-0
  • Mol. F.C15H30O3
  • Mol. W.258.40 g/mol
  • Stock Status:Custom Synthesis
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Methoxyacetic acid tridecyl ester
Methoxyacetic acid tridecyl ester
  • CAT. No.E620021
  • CAS. No.959246-45-8
  • Mol. F.C16H32O3
  • Mol. W.272.42 g/mol
  • Stock Status:Custom Synthesis
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Methoxyacetic acid, tetradecyl ester
Methoxyacetic acid, tetradecyl ester
  • CAT. No.E620022
  • CAS. No.959263-00-4
  • Mol. F.C17H34O3
  • Mol. W.286.45 g/mol
  • Stock Status:Custom Synthesis
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Methoxyacetic acid, pentadecyl ester
Methoxyacetic acid, pentadecyl ester
  • CAT. No.E620023
  • CAS. No.959264-10-9
  • Mol. F.C18H36O3
  • Mol. W.300.48 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole(2R,3R)Regiamer
Efinaconazole(2R,3R)Regiamer
  • CAT. No.E620024
  • CAS. No.2122222-10-8
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Custom Synthesis
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4-Methyl-1,2,3,6-Tetrahydropyridine Hydrochloride
4-Methyl-1,2,3,6-Tetrahydropyridine Hydrochloride
  • CAT. No.E620025
  • CAS. No.95019-16-2
  • Mol. F.C6H11N.HCl
  • Mol. W.133.62 g/mol
  • Stock Status:Custom Synthesis
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4-Chloromethyl-piperidine
4-Chloromethyl-piperidine
  • CAT. No.E620026
  • CAS. No.58013-32-4
  • Mol. F.C6H12ClN
  • Mol. W.133.62 g/mol
  • Stock Status:Custom Synthesis
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4-(Tert-butoxymethyl)Piperidine
4-(Tert-butoxymethyl)Piperidine
  • CAT. No.E620027
  • CAS. No.184042-90-8
  • Mol. F.C10H21NO
  • Mol. W.171.28 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole KSM - Protected Epoxy Impurity
Efinaconazole KSM - Protected Epoxy Impurity
  • CAT. No.E620028
  • CAS. No.135267-12-8
  • Mol. F.C15H18F2O3
  • Mol. W.284.30 g/mol
  • Stock Status:Custom Synthesis
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(2R,3R)-3-(2,4-Difluorophenyl)-3,4-Epoxybutan-2-ol
(2R,3R)-3-(2,4-Difluorophenyl)-3,4-Epoxybutan-2-ol
  • CAT. No.E620029
  • CAS. No.126918-35-2
  • Mol. F.C10H10F2O2
  • Mol. W.200.18 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 29
Efinaconazole Impurity 29
  • CAT. No.E620030
  • CAS. No.2055912-03-1
  • Mol. F.C24H32FN5O
  • Mol. W.425.55 g/mol
  • Stock Status:Custom Synthesis
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N,N-Dimethylformamide Azine Dihydrochloride
N,N-Dimethylformamide Azine Dihydrochloride
  • CAT. No.E620031
  • CAS. No.868670-46-6
  • Mol. F.C6H14N4.2HCl
  • Mol. W.215.12 g/mol
  • Stock Status:Custom Synthesis
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N,N'-Dimethylformamide Azine
N,N'-Dimethylformamide Azine
  • CAT. No.E620031A
  • CAS. No.16114-05-9
  • Mol. F.C6H14N4
  • Mol. W.142.20 g/mol
  • Stock Status:Custom Synthesis
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(3R)-2-(2,4-Difluorophenyl)-3-(3-Methylenepiperidin-1-yl)-1- (1H-1,2,4-Triazol-1-yl)Butan-2-ol
(3R)-2-(2,4-Difluorophenyl)-3-(3-Methylenepiperidin-1-yl)-1- (1H-1,2,4-Triazol-1-yl)Butan-2-ol
  • CAT. No.E620032
  • CAS. No.164650-54-8
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity A1
Efinaconazole Impurity A1
  • CAT. No.E620033
  • CAS. No.126918-17-0
  • Mol. F.C14H16F2O3
  • Mol. W.270.27 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole
Efinaconazole
  • CAT. No.E620034
  • CAS. No.NA
  • Mol. F.C18H22F2N4O
  • Mol. W.348.39 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 31
Efinaconazole Impurity 31
  • CAT. No.E620035
  • CAS. No.127001-03-0
  • Mol. F.C14H16F2O3
  • Mol. W.270.27 g/mol
  • Stock Status:Custom Synthesis
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Tetraphenyl dipropyleneglycol diphosphate
Tetraphenyl dipropyleneglycol diphosphate
  • CAT. No.E620041
  • CAS. No.80584-85-6
  • Mol. F.C30H32O7P2
  • Mol. W.566.52 g/mol
  • Stock Status:Custom Synthesis
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3,8-Dimethylundecane
3,8-Dimethylundecane
  • CAT. No.E620042
  • CAS. No.17301-30-3
  • Mol. F.C13H28
  • Mol. W.184.36 g/mol
  • Stock Status:Custom Synthesis
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1-pentyl-2-propyl-Cyclopentane
1-pentyl-2-propyl-Cyclopentane
  • CAT. No.E620045
  • CAS. No.62199-51-3
  • Mol. F.C13H26
  • Mol. W.182.35 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 18
Efinaconazole Impurity 18
  • CAT. No.E620046
  • CAS. No.150803-08-0
  • Mol. F.C12H14FN3O2
  • Mol. W.251.30 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 19
Efinaconazole Impurity 19
  • CAT. No.E620047
  • CAS. No.NA
  • Mol. F.C12H15N3O2
  • Mol. W.233.27 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 20
Efinaconazole Impurity 20
  • CAT. No.E620048
  • CAS. No.135133-23-2
  • Mol. F.C17H21F2N3O3
  • Mol. W.353.36 g/mol
  • Stock Status:Custom Synthesis
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(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol & (2R,3S)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol {enantiomeric mixture}Impurity -A3
(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol & (2R,3S)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol {enantiomeric mixture}Impurity -A3
  • CAT. No.E620049
  • CAS. No.135272-36-5 & 135270-11-0
  • Mol. F.C24H26F4N6O4
  • Mol. W.538.49 g/mol
  • Stock Status:Custom Synthesis
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(2R,3R)-2-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol
(2R,3R)-2-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol
  • CAT. No.E620051
  • CAS. No.NA
  • Mol. F.C12H15N3O2
  • Mol. W.233.27 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Epoxide
Efinaconazole Epoxide
  • CAT. No.E620053
  • CAS. No.NA
  • Mol. F.C18H22F2N4O2
  • Mol. W.364.39 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole 4-Desfluoro Impurity
Efinaconazole 4-Desfluoro Impurity
  • CAT. No.E620054
  • CAS. No.NA
  • Mol. F.C18H23FN4O
  • Mol. W.330.40 g/mol
  • Stock Status:Custom Synthesis
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4,6-dimethyldodecane
4,6-dimethyldodecane
  • CAT. No.E620055
  • CAS. No.NA
  • Mol. F.C14H30
  • Mol. W.198.39 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 22
Efinaconazole Impurity 22
  • CAT. No.E620056
  • CAS. No.241479-73-2
  • Mol. F.C12H11F2N3O
  • Mol. W.251.23 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 17
Efinaconazole Impurity 17
  • CAT. No.E620057
  • CAS. No.2055038-64-5
  • Mol. F.C18H23FN4O
  • Mol. W.330.40 g/mol
  • Stock Status:Custom Synthesis
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(2R,3R)-2-(2,4-Difluorophenyl)-1-(4H-1,2,4-triazol-4-yl)butane-2,3-diol
(2R,3R)-2-(2,4-Difluorophenyl)-1-(4H-1,2,4-triazol-4-yl)butane-2,3-diol
  • CAT. No.E620058
  • CAS. No.2122222-14-2
  • Mol. F.C12H13F2N3O2
  • Mol. W.269.25 g/mol
  • Stock Status:Custom Synthesis
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(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl methanesulfonate
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl methanesulfonate
  • CAT. No.E620059
  • CAS. No.133775-26-5
  • Mol. F.C13H15F2N3O4S
  • Mol. W.347.34 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 34
Efinaconazole Impurity 34
  • CAT. No.E620060
  • CAS. No.6965-45-3
  • Mol. F.C12H6F4
  • Mol. W.226.17 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 25
Efinaconazole Impurity 25
  • CAT. No.E620061
  • CAS. No.241479-75-4
  • Mol. F.C13H14F2N4O2
  • Mol. W.296.27 g/mol
  • Stock Status:Custom Synthesis
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(2S,3R)-3-(2,5-diflurophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazole-1-yl)thiobutyramide
(2S,3R)-3-(2,5-diflurophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazole-1-yl)thiobutyramide
  • CAT. No.E620062
  • CAS. No.2170932-49-5
  • Mol. F.C13H14F2N4OS
  • Mol. W.312.34 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 15
Efinaconazole Impurity 15
  • CAT. No.E620067
  • CAS. No.2252350-11-9
  • Mol. F.C18H22FN4O.F
  • Mol. W.348.39 g/mol
  • Stock Status:Custom Synthesis
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Mixture of (2R,3S) & (2S,3R) Efinaconazole
Mixture of (2R,3S) & (2S,3R) Efinaconazole
  • CAT. No.E620068
  • CAS. No.188904-85-0
  • Mol. F.C36H44F4N8O2
  • Mol. W.696.78 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 38
Efinaconazole Impurity 38
  • CAT. No.E620069
  • CAS. No.2055038-65-6
  • Mol. F.C18H24N4O
  • Mol. W.312.41 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole (2R,3S) Epoxide
Efinaconazole (2R,3S) Epoxide
  • CAT. No.E620070
  • CAS. No.127000-90-2
  • Mol. F.C12H11F2N3O
  • Mol. W.251.23 g/mol
  • Stock Status:Instock
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Efinaconazole Impurity 5
Efinaconazole Impurity 5
  • CAT. No.E620071
  • CAS. No.NA
  • Mol. F.C18H21FN4O
  • Mol. W.328.38 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 6
Efinaconazole Impurity 6
  • CAT. No.E620072
  • CAS. No.NA
  • Mol. F.C18H21FN4O
  • Mol. W.328.38 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 7
Efinaconazole Impurity 7
  • CAT. No.E620073
  • CAS. No.NA
  • Mol. F.C18H21FN4O
  • Mol. W.328.38 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 8
Efinaconazole Impurity 8
  • CAT. No.E620074
  • CAS. No.NA
  • Mol. F.C18H21FN4O
  • Mol. W.328.38 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 2
Efinaconazole Impurity 2
  • CAT. No.E620075
  • CAS. No.NA
  • Mol. F.C18H24F2N4O2
  • Mol. W.366.41 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole Impurity 10
Efinaconazole Impurity 10
  • CAT. No.E620076
  • CAS. No.NA
  • Mol. F.C18H22FN4O
  • Mol. W.329.39 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Efinaconazole H4 metabolite
Efinaconazole H4 metabolite
  • CAT. No.E620065
  • CAS. No.NA
  • Mol. F.C18H24F2N4O3
  • Mol. W.382.40 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole H3 metabolite
Efinaconazole H3 metabolite
  • CAT. No.E620066
  • CAS. No.NA
  • Mol. F.C10H9F2N3O
  • Mol. W.225.19 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Efinaconazole D4
Efinaconazole D4
  • CAT. No.E620063
  • CAS. No.NA
  • Mol. F.C18H18D4F2N4O
  • Mol. W.352.40 g/mol
  • Stock Status:Custom Synthesis
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Efinaconazole D6
Efinaconazole D6
  • CAT. No.E620064
  • CAS. No.NA
  • Mol. F.C18H16D6F2N4O
  • Mol. W.354.40 g/mol
  • Stock Status:Custom Synthesis
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