Edaravone Related Compounds & Impurities

Edaravone is a free-radical scavenger neuroprotectant used for acute ischaemic stroke (in Japan) and amyotrophic lateral sclerosis.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Edaravone reference standards, pharmacopeial and non-pharmacopeial Edaravone impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Edaravone-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Edaravone
Edaravone
  • CAT. No.E220000
  • CAS. No.89-25-8
  • Mol. F.C10H10N2O
  • Mol. W.174.20 g/mol
  • Stock Status:Instock
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Edaravone Impurity IV
Edaravone Impurity IV
  • CAT. No.E220001
  • CAS. No.7477-67-0
  • Mol. F.C20H18N4O2
  • Mol. W.346.38 g/mol
  • Stock Status:Instock
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Edaravone Dimer Impurity
Edaravone Dimer Impurity
  • CAT. No.E220002
  • CAS. No.177415-76-8
  • Mol. F.C20H18N4O2
  • Mol. W.346.38 g/mol
  • Stock Status:Instock
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3-Methyl-1-phenyl-2-pyrazoline-5-one
3-Methyl-1-phenyl-2-pyrazoline-5-one
  • CAT. No.E220003
  • CAS. No.19735-89-8
  • Mol. F.C10H10N2O
  • Mol. W.174.2 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Trimer Impurity
Edaravone Trimer Impurity
  • CAT. No.E220004
  • CAS. No.68195-63-1
  • Mol. F.C30H26N6O3
  • Mol. W.518.57 g/mol
  • Stock Status:Instock
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4,5-Dihydro-alpha-(hydroxymethyl)-alpha,3-dimethyl-5-oxo-1-phenyl-1h-pyrazole-4-methanesulfonic acid
4,5-Dihydro-alpha-(hydroxymethyl)-alpha,3-dimethyl-5-oxo-1-phenyl-1h-pyrazole-4-methanesulfonic acid
  • CAT. No.E220005A
  • CAS. No.1242471-40-4
  • Mol. F.C13H16N2O5S
  • Mol. W.312.34 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 2
Edaravone Impurity 2
  • CAT. No.E220006A
  • CAS. No.1357477-99-6
  • Mol. F.C13H14N2O6S
  • Mol. W.326.33 g/mol
  • Stock Status:Limited Stock
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Edaravone Impurity 3 Sodium Salt
Edaravone Impurity 3 Sodium Salt
  • CAT. No.E220007
  • CAS. No.1322767-63-4
  • Mol. F.C13H16N2O4S.Na
  • Mol. W.319.33 g/mol
  • Stock Status:Custom Synthesis
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Edaravone impurity P3
Edaravone impurity P3
  • CAT. No.E220008
  • CAS. No.1323485-71-7
  • Mol. F.C13H16N2O4S
  • Mol. W.296.35 g/mol
  • Stock Status:Custom Synthesis
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4,4'-(Ethane-1,1-diyl)bis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one)
4,4'-(Ethane-1,1-diyl)bis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one)
  • CAT. No.E220009
  • CAS. No.82772-85-8
  • Mol. F.C22H22N4O2
  • Mol. W.374.44 g/mol
  • Stock Status:Instock
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Edaravone N-Oxide
Edaravone N-Oxide
  • CAT. No.E220010
  • CAS. No.152494-76-3
  • Mol. F.C10H10N2O2
  • Mol. W.190.20 g/mol
  • Stock Status:Instock
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Edaravone Dimer N-Oxide
Edaravone Dimer N-Oxide
  • CAT. No.E220011
  • CAS. No.NA
  • Mol. F.C20H16N4O3
  • Mol. W.360.37 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity V
Edaravone Impurity V
  • CAT. No.E220012
  • CAS. No.124009-63-8
  • Mol. F.C30H26N6O3
  • Mol. W.518.57 g/mol
  • Stock Status:Instock
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Edaravone Impurity 8
Edaravone Impurity 8
  • CAT. No.E220013
  • CAS. No.6078-46-2
  • Mol. F.C12H16N2O2
  • Mol. W.220.30 g/mol
  • Stock Status:Instock
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Edaravone Impurity 9
Edaravone Impurity 9
  • CAT. No.E220014
  • CAS. No.1016-41-7
  • Mol. F.C12H14N2O
  • Mol. W.202.25 g/mol
  • Stock Status:Instock
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Edaravone Impurity 10
Edaravone Impurity 10
  • CAT. No.E220015
  • CAS. No.607-67-0
  • Mol. F.C10H9NO
  • Mol. W.159.19 g/mol
  • Stock Status:Instock
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Edaravone Impurity 4
Edaravone Impurity 4
  • CAT. No.E220018
  • CAS. No.NA
  • Mol. F.C12H14N2O
  • Mol. W.202.25 g/mol
  • Stock Status:Instock
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Edaravone Impurity 22
Edaravone Impurity 22
  • CAT. No.E220019
  • CAS. No.122395-42-0
  • Mol. F.C10H10N2O2
  • Mol. W.190.20 g/mol
  • Stock Status:Instock
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Edaravone Impurity 27
Edaravone Impurity 27
  • CAT. No.E220020
  • CAS. No.1005763-87-0
  • Mol. F.C10H10N2O3
  • Mol. W.206.20 g/mol
  • Stock Status:Custom Synthesis
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5-methoxy-3-methyl-1-phenyl-1H-Pyrazole
5-methoxy-3-methyl-1-phenyl-1H-Pyrazole
  • CAT. No.E220021
  • CAS. No.NA
  • Mol. F.C11H12N2O
  • Mol. W.188.23 g/mol
  • Stock Status:Custom Synthesis
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5,5`-dimethyl-2,2`-diphenyl-2`,4`-dihydro-2H,3`H-[3,4`-bipyrazol]-3`-one
5,5`-dimethyl-2,2`-diphenyl-2`,4`-dihydro-2H,3`H-[3,4`-bipyrazol]-3`-one
  • CAT. No.E220022
  • CAS. No.NA
  • Mol. F.C20H18N4O
  • Mol. W.330.38 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 16
Edaravone Impurity 16
  • CAT. No.E220023
  • CAS. No.153952-07-9
  • Mol. F.C20H18N4O3
  • Mol. W.362.38 g/mol
  • Stock Status:Instock
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(E)-methyl 3-(2-phenylhydrazono)butanoate
(E)-methyl 3-(2-phenylhydrazono)butanoate
  • CAT. No.E220029
  • CAS. No.NA
  • Mol. F.C11H14N2O2
  • Mol. W.206.24 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 11
Edaravone Impurity 11
  • CAT. No.E220030
  • CAS. No.881-05-0
  • Mol. F.C10H8N2O2
  • Mol. W.188.20 g/mol
  • Stock Status:Instock
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2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
  • CAT. No.E220032
  • CAS. No.NA
  • Mol. F.C13H16N2O3S3
  • Mol. W.344.47 g/mol
  • Stock Status:Custom Synthesis
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(1R,2R)-2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
(1R,2R)-2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
  • CAT. No.E220033
  • CAS. No.NA
  • Mol. F.C13H16N2O3S3
  • Mol. W.344.47 g/mol
  • Stock Status:Custom Synthesis
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(1R,2S)-2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
(1R,2S)-2-hydroxy-1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-1-sulfonodithioic O-acid
  • CAT. No.E220034
  • CAS. No.NA
  • Mol. F.C13H16N2O3S3
  • Mol. W.344.47 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 35
Edaravone Impurity 35
  • CAT. No.E220035
  • CAS. No.NA
  • Mol. F.C13H14N2O6S
  • Mol. W.326.33 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 37
Edaravone Impurity 37
  • CAT. No.E220036
  • CAS. No.NA
  • Mol. F.C13H15N3O3S
  • Mol. W.293.34 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 36
Edaravone Impurity 36
  • CAT. No.E220037
  • CAS. No.NA
  • Mol. F.C20H16N4O3
  • Mol. W.360.37 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Dimer Ethyl Impurity
Edaravone Dimer Ethyl Impurity
  • CAT. No.E220038
  • CAS. No.NA
  • Mol. F.C22H22N4O2
  • Mol. W.374.44 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 1
Edaravone Impurity 1
  • CAT. No.E220039
  • CAS. No.1086213-77-5
  • Mol. F.C10H10N2O3
  • Mol. W.206.20 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Impurity 3
Edaravone Impurity 3
  • CAT. No.E220040
  • CAS. No.NA
  • Mol. F.C13H15N2O4S.Na
  • Mol. W.318.32 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Edaravone O-beta-D-glucuronide
Edaravone O-beta-D-glucuronide
  • CAT. No.E220024
  • CAS. No.67566-02-3
  • Mol. F.C16H18N2O7
  • Mol. W.350.32 g/mol
  • Stock Status:Under Synthesis
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Edaravone Sulfate
Edaravone Sulfate
  • CAT. No.E220025
  • CAS. No.76407-98-2
  • Mol. F.C10H10N2O4S
  • Mol. W.254.26 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Sulfate Triethylamine
Edaravone Sulfate Triethylamine
  • CAT. No.E220026
  • CAS. No.NA
  • Mol. F.C10H10N2O4S.C6H15N
  • Mol. W.355.45 g/mol
  • Stock Status:Under Synthesis
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Isotope Labelled Compounds

Edaravone D5
Edaravone D5
  • CAT. No.E220017
  • CAS. No.1228765-67-0
  • Mol. F.C10H5D5N2O
  • Mol. W.179.23 g/mol
  • Stock Status:Under Synthesis
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Edaravone-D5 Glucuronide Sodium Salt
Edaravone-D5 Glucuronide Sodium Salt
  • CAT. No.E220027
  • CAS. No.NA
  • Mol. F.C16H12D5N2NaO7
  • Mol. W.377.34 g/mol
  • Stock Status:Custom Synthesis
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Edaravone Sulfate Triethylamine SaltD5
Edaravone Sulfate Triethylamine SaltD5
  • CAT. No.E220028
  • CAS. No.NA
  • Mol. F.C16H20D5N3O4S
  • Mol. W.360.48 g/mol
  • Stock Status:Custom Synthesis
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