Doxepin Related Compounds & Impurities

Doxepin is a tricyclic antidepressant with potent H1 and H2 antihistaminic activity, used for depression, anxiety and, at low doses, chronic insomnia.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Doxepin reference standards, pharmacopeial and non-pharmacopeial Doxepin impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Doxepin-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Doxepin Hydrochloride
Doxepin Hydrochloride
  • CAT. No.D050000
  • CAS. No.1229-29-4
  • Mol. F.C19H21NO.HCl
  • Mol. W.315.84 g/mol
  • Stock Status:Instock
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Doxepin EP impurity A
Doxepin EP impurity A
  • CAT. No.D050001
  • CAS. No.4504-87-4
  • Mol. F.C14H10O2
  • Mol. W.210.23 g/mol
  • Stock Status:Instock
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Doxepin EP Impurity B
Doxepin EP Impurity B
  • CAT. No.D050002
  • CAS. No.4504-88-5
  • Mol. F.C19H23NO2
  • Mol. W.297.39 g/mol
  • Stock Status:Instock
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Doxepin EP Impurity C
Doxepin EP Impurity C
  • CAT. No.D050003
  • CAS. No.1225-56-5
  • Mol. F.C18H19NO
  • Mol. W.265.00 g/mol
  • Stock Status:Instock
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Doxepin EP Impurity C Hydrochloride
Doxepin EP Impurity C Hydrochloride
  • CAT. No.D050003A
  • CAS. No.4504-96-5
  • Mol. F.C18H20NOCl
  • Mol. W.301.81 g/mol
  • Stock Status:Instock
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Doxepin EP Impurity D
Doxepin EP Impurity D
  • CAT. No.D050004
  • CAS. No.3607-18-9
  • Mol. F.C19H21NO
  • Mol. W.279.38 g/mol
  • Stock Status:Custom Synthesis
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Doxepin N-Oxide Impurity
Doxepin N-Oxide Impurity
  • CAT. No.D050005
  • CAS. No.22684-91-9
  • Mol. F.C19H21NO2
  • Mol. W.295.38 g/mol
  • Stock Status:Instock
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Nor Doxepin Hydrochloride
Nor Doxepin Hydrochloride
  • CAT. No.D050007
  • CAS. No.2887-91-4
  • Mol. F.C18H20ClNO
  • Mol. W.301.81 g/mol
  • Stock Status:Instock
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Doxepin Related Compound D
Doxepin Related Compound D
  • CAT. No.D050009
  • CAS. No.3607-18-9(Freebase)
  • Mol. F.C19H24ClNO
  • Mol. W.317.85 g/mol
  • Stock Status:Custom Synthesis
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(E/Z)-Doxepin Glucuronide
(E/Z)-Doxepin Glucuronide
  • CAT. No.D050011
  • CAS. No.788790-52-3
  • Mol. F.C25H29NO7
  • Mol. W.455.51 g/mol
  • Stock Status:Custom Synthesis
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Doxepin Impurity 7
Doxepin Impurity 7
  • CAT. No.D050012
  • CAS. No.21324-99-2
  • Mol. F.C16H12O2
  • Mol. W.236.26 g/mol
  • Stock Status:Custom Synthesis
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(E)-N-Acetyl-N-desmethyl Doxepin
(E)-N-Acetyl-N-desmethyl Doxepin
  • CAT. No.D050013
  • CAS. No.250331-54-5
  • Mol. F.C20H21NO2
  • Mol. W.307.39 g/mol
  • Stock Status:Instock
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1,6-Dihydrodoxepin
1,6-Dihydrodoxepin
  • CAT. No.D050014
  • CAS. No.2185273-00-9
  • Mol. F.C19H23NO
  • Mol. W.281.39 g/mol
  • Stock Status:Custom Synthesis
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Dibenz[b,e]oxepin Carbamic Acid Derivative
Dibenz[b,e]oxepin Carbamic Acid Derivative
  • CAT. No.D050015
  • CAS. No.NA
  • Mol. F.C21H20Cl3NO3
  • Mol. W.440.75 g/mol
  • Stock Status:Custom Synthesis
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(E)-N-Desmethyl-N-formyl Doxepin
(E)-N-Desmethyl-N-formyl Doxepin
  • CAT. No.D050016
  • CAS. No.250331-52-3
  • Mol. F.C19H19NO2
  • Mol. W.293.36 g/mol
  • Stock Status:Instock
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Doxepin Impurity 3 (mixture of E,Z-isomers)
Doxepin Impurity 3 (mixture of E,Z-isomers)
  • CAT. No.D050017
  • CAS. No.21324-99-2
  • Mol. F.C16H12O2
  • Mol. W.236.27 g/mol
  • Stock Status:Custom Synthesis
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2-(Dibenz[b,e]oxepin-11(6H)-ylidene)acetaldehyde
2-(Dibenz[b,e]oxepin-11(6H)-ylidene)acetaldehyde
  • CAT. No.D050018
  • CAS. No.21324-99-2
  • Mol. F.C16H12O2
  • Mol. W.236.27 g/mol
  • Stock Status:Custom Synthesis
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(E)-Doxepin
(E)-Doxepin
  • CAT. No.D050019
  • CAS. No.3607-34-9
  • Mol. F.C19H21NO
  • Mol. W.279.39 g/mol
  • Stock Status:Custom Synthesis
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(Z)-Doxepin
(Z)-Doxepin
  • CAT. No.D050020
  • CAS. No.3607-18-9
  • Mol. F.C19H21NO
  • Mol. W.279.39 g/mol
  • Stock Status:Custom Synthesis
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Doxepin EP Impurity D Hydrochloride
Doxepin EP Impurity D Hydrochloride
  • CAT. No.D050020A
  • CAS. No.25127-31-5
  • Mol. F.C19H21NO.HCl
  • Mol. W.315.84 g/mol
  • Stock Status:Custom Synthesis
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Doxepin Impurity 1
Doxepin Impurity 1
  • CAT. No.D050024
  • CAS. No.83473-99-8
  • Mol. F.C16H12O2
  • Mol. W.236.27 g/mol
  • Stock Status:Custom Synthesis
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Doxepin Impurity 2
Doxepin Impurity 2
  • CAT. No.D050025
  • CAS. No.83473-98-7
  • Mol. F.C16H12O2
  • Mol. W.236.27 g/mol
  • Stock Status:Custom Synthesis
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Doxepin-N-beta-D-Glucuronide
Doxepin-N-beta-D-Glucuronide
  • CAT. No.D050026
  • CAS. No.1075185-73-7
  • Mol. F.C25H29NO7
  • Mol. W.455.50 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso N-Desmethyl Doxepin Impurity
N-Nitroso N-Desmethyl Doxepin Impurity
  • CAT. No.D050027
  • CAS. No.NA
  • Mol. F.C18H18N2O2
  • Mol. W.294.35 g/mol
  • Stock Status:Instock
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(E)-Doxepin Hydrochloride
(E)-Doxepin Hydrochloride
  • CAT. No.D050028
  • CAS. No.4698-39-9
  • Mol. F.C19H22ClNO
  • Mol. W.315.84 g/mol
  • Stock Status:Custom Synthesis
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Doxepin Impurity 4
Doxepin Impurity 4
  • CAT. No.D050029
  • CAS. No.94432-54-9
  • Mol. F.C19H25NO
  • Mol. W.283.41 g/mol
  • Stock Status:Custom Synthesis
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Methyl-2-(phenoxymethyl)benzoate
Methyl-2-(phenoxymethyl)benzoate
  • CAT. No.D050030
  • CAS. No.NA
  • Mol. F.C15H14O3
  • Mol. W.242.27 g/mol
  • Stock Status:Custom Synthesis
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Doxepin EP Impurity B Hydrochloride Salt
Doxepin EP Impurity B Hydrochloride Salt
  • CAT. No.D050031
  • CAS. No.NA
  • Mol. F.C19H24ClNO2
  • Mol. W.333.85 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Desmethyl Cis-Doxepin
N-Nitroso Desmethyl Cis-Doxepin
  • CAT. No.D050032
  • CAS. No.NA
  • Mol. F.C18H18N2O2
  • Mol. W.294.35 g/mol
  • Stock Status:Instock
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Doxepin N-Oxide Hydrochloride
Doxepin N-Oxide Hydrochloride
  • CAT. No.D050033
  • CAS. No.2734342-87-9
  • Mol. F.C19H21NO2.HCl
  • Mol. W.331.84 g/mol
  • Stock Status:Instock
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N-Nitroso N-Desmethyl Doxepin EP impurity B
N-Nitroso N-Desmethyl Doxepin EP impurity B
  • CAT. No.D050034
  • CAS. No.NA
  • Mol. F.C18H20N2O3
  • Mol. W.312.40 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Doxepin-D3
Doxepin-D3
  • CAT. No.D050006
  • CAS. No.NA
  • Mol. F.C19H18D3NO
  • Mol. W.282.39 g/ mol
  • Stock Status:Under Synthesis
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Doxepin-d3 Hydrochloride
Doxepin-d3 Hydrochloride
  • CAT. No.D050006A
  • CAS. No.347840-07-7
  • Mol. F.C19H19D3NOCl
  • Mol. W.318.86 g/mol
  • Stock Status:Instock
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Nor Doxepin-D3 Hydrochloride
Nor Doxepin-D3 Hydrochloride
  • CAT. No.D050008
  • CAS. No.1331665-54-3
  • Mol. F.C18H17D3ClNO
  • Mol. W.304.83 g/mol
  • Stock Status:Instock
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Doxepin D6 Hydrochloride
Doxepin D6 Hydrochloride
  • CAT. No.D050021
  • CAS. No.NA
  • Mol. F.C19H15D6NO.HCl
  • Mol. W.321.87 g/mol
  • Stock Status:Instock
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Doxepin-13CD3 Hydrochloride
Doxepin-13CD3 Hydrochloride
  • CAT. No.D050022
  • CAS. No.NA
  • Mol. F.C1813CH19D3ClNO
  • Mol. W.319.85 g/mol
  • Stock Status:Custom Synthesis
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