Donepezil Hydrochloride Related Compounds & Impurities

Donepezil Hydrochloride is a reversible acetylcholinesterase inhibitor that enhances cholinergic neurotransmission, used for mild-to-moderate Alzheimer's disease.

Simson Pharma Limited along with its subsidiary offices Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) is a trusted manufacturer and supplier of high-quality pharmaceutical reference standards, offering a comprehensive portfolio of Donepezil Hydrochloride reference standards, pharmacopeial and non-pharmacopeial Donepezil Hydrochloride impurities, related compounds, related substances, metabolites, stable isotope-labelled compounds, deuterium labelled compounds and nitrosamine (N-NO) reference standards.

These materials support pharmaceutical research and development, product development, ANDA and DMF submissions, quality control (QC), analytical method development and validation, stability studies, impurity identification, and genotoxic impurity assessment.

Our Donepezil Hydrochloride-related reference standards are thoroughly characterized using advanced analytical techniques and are supplied with comprehensive Certificates of Analysis (COA) and supporting analytical data from our USFDA certified, ISO 17025 and ISO 17034 accredited Lab, to meet global regulatory expectations. EP and USP traceable reference standards can also be provided upon request, subject to availability. Simson is also a provider of EP and USP traceable standards. To ensure consistent quality and reliability, our reference standards are periodically re-tested according to established quality management procedures.

Pharmaceutical Reference Standards / Impurity Standards

Donepezil Hydrochloride
Donepezil Hydrochloride
  • CAT. No.D040000
  • CAS. No.120011-70-3
  • Mol. F.C24H29NO3.HCl
  • Mol. W.415.95 g/mol
  • Stock Status:Instock
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Donepezil Hydrochloride Monohydrate
Donepezil Hydrochloride Monohydrate
  • CAT. No.D040000B
  • CAS. No.884740-09-4
  • Mol. F.C24H29NO3·HCl·H2O
  • Mol. W.433.97 g/mol
  • Stock Status:Instock
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Deoxy Donepezil Hydrochloride
Deoxy Donepezil Hydrochloride
  • CAT. No.D040001
  • CAS. No.1034439-57-0
  • Mol. F.C24H32ClNO2
  • Mol. W.401.97 g/mol
  • Stock Status:Instock
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Deoxy Donapezil
Deoxy Donapezil
  • CAT. No.D040001A
  • CAS. No.844694-84-4
  • Mol. F.C24H31NO2
  • Mol. W.365.51 g/mol
  • Stock Status:Instock
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Donepezil Dehydrodeoxy Impurity
Donepezil Dehydrodeoxy Impurity
  • CAT. No.D040002
  • CAS. No.120013-45-8
  • Mol. F.C24H29NO2
  • Mol. W.363.49 g/mol
  • Stock Status:Instock
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Donepezil Impurity B Hydrochloride Salt
Donepezil Impurity B Hydrochloride Salt
  • CAT. No.D040003
  • CAS. No.120013-39-0
  • Mol. F.C17H24ClNO3
  • Mol. W.325.83 g/mol
  • Stock Status:Instock
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5-O-Desmethyl Donepezil
5-O-Desmethyl Donepezil
  • CAT. No.D040004
  • CAS. No.120013-57-2
  • Mol. F.C23H27NO3
  • Mol. W.365.47 g/mol
  • Stock Status:Instock
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Donepezil N-Oxide
Donepezil N-Oxide
  • CAT. No.D040005
  • CAS. No.120013-84-5
  • Mol. F.C24H29NO4
  • Mol. W.395.49 g/mol
  • Stock Status:Instock
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6-O-Desmethyl Donepezil
6-O-Desmethyl Donepezil
  • CAT. No.D040006
  • CAS. No.120013-56-1
  • Mol. F.C23H27NO3
  • Mol. W.365.47 g/mol
  • Stock Status:Instock
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Donepezil Impurity (USP Imp b)(5,6-Dimethoxy-2-(4-pyridylmethyl)-1-indanone)(Pyridine Analog)
Donepezil Impurity (USP Imp b)(5,6-Dimethoxy-2-(4-pyridylmethyl)-1-indanone)(Pyridine Analog)
  • CAT. No.D040007
  • CAS. No.4803-57-0
  • Mol. F.C17H17NO3
  • Mol. W.283.32 g/mol
  • Stock Status:Under Synthesis
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Donepezil Impurity 1
Donepezil Impurity 1
  • CAT. No.D040008
  • CAS. No.149874-91-9
  • Mol. F.C17H21NO3
  • Mol. W.287.35 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity
Donepezil Impurity
  • CAT. No.D040009
  • CAS. No.844694-83-3
  • Mol. F.C17H25NO2
  • Mol. W.275.39 g/mol
  • Stock Status:Custom Synthesis
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Donepezil EP Impurity B
Donepezil EP Impurity B
  • CAT. No.D040010
  • CAS. No.2107-69-9
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Instock
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Donepezil Open Ring Impurity
Donepezil Open Ring Impurity
  • CAT. No.D040011
  • CAS. No.197010-25-6
  • Mol. F.C24H29NO5
  • Mol. W.411.49 g/mol
  • Stock Status:Under Synthesis
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Donepezil Open Ring Impurity Sodium
Donepezil Open Ring Impurity Sodium
  • CAT. No.D040011A
  • CAS. No.197010-25-6 (free base)
  • Mol. F.C24H28NO5.Na
  • Mol. W.433.47 g/mol
  • Stock Status:Instock
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Donepezil Benzyl Bromide
Donepezil Benzyl Bromide
  • CAT. No.D040013
  • CAS. No.844694-85-5
  • Mol. F.C31H36BrNO3
  • Mol. W.550.53 g/mol
  • Stock Status:Instock
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Donepezil Benzyl Chloride
Donepezil Benzyl Chloride
  • CAT. No.D040013A
  • CAS. No.937362-16-8
  • Mol. F.C31H36ClNO3
  • Mol. W.506.07 g/mol
  • Stock Status:Instock
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Donepezil benzyl
Donepezil benzyl
  • CAT. No.D040013B
  • CAS. No.937362-16-8
  • Mol. F.C31H36ClNO3
  • Mol. W.506.07 g/mol
  • Stock Status:Custom Synthesis
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Hydroxy Donapezil
Hydroxy Donapezil
  • CAT. No.D040014
  • CAS. No.197010-20-1
  • Mol. F.C24H29NO4
  • Mol. W.395.50 g/mol
  • Stock Status:Instock
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Donepezil (base)
Donepezil (base)
  • CAT. No.D040015
  • CAS. No.120014-06-4
  • Mol. F.C24H29NO3
  • Mol. W.379.45 g/mol
  • Stock Status:Instock
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2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • CAT. No.D040020
  • CAS. No.NA
  • Mol. F.C24H27NO3
  • Mol. W.377.48 g/mol
  • Stock Status:Custom Synthesis
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Donepezil EP Impurity F
Donepezil EP Impurity F
  • CAT. No.D040021
  • CAS. No.145546-80-1
  • Mol. F.C24H27NO3
  • Mol. W.377.48 g/mol
  • Stock Status:Instock
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Donapezile unknown Impurity
Donapezile unknown Impurity
  • CAT. No.D040022
  • CAS. No.NA
  • Mol. F.C18H23NO3
  • Mol. W.301.17 g/mol
  • Stock Status:Custom Synthesis
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4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridine 1-oxide
4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridine 1-oxide
  • CAT. No.D040023
  • CAS. No.896134-06-8
  • Mol. F.C17H15NO4
  • Mol. W.297.31 g/mol
  • Stock Status:Instock
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3-Hydroxy Donepezil
3-Hydroxy Donepezil
  • CAT. No.D040024
  • CAS. No.2097683-67-3
  • Mol. F.C24H29NO4
  • Mol. W.395.50 g/mol
  • Stock Status:Limited Stock
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3-Hydroxy Donepezil Hydrochloride
3-Hydroxy Donepezil Hydrochloride
  • CAT. No.D040024A
  • CAS. No.2097683-67-3 (free base)
  • Mol. F.C24H29NO4.HCl
  • Mol. W.431.95 g/mol
  • Stock Status:Instock
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Donepezil O-Benzyl Enol Ether
Donepezil O-Benzyl Enol Ether
  • CAT. No.D040025
  • CAS. No.NA
  • Mol. F.C31H35NO3
  • Mol. W.469.61 g/mol
  • Stock Status:Custom Synthesis
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4,5-Dimethoxy-1-indanone
4,5-Dimethoxy-1-indanone
  • CAT. No.D040026
  • CAS. No. 6342-80-9
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Custom Synthesis
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4,6-dimethoxy-2,3-dihydroinden-1-one
4,6-dimethoxy-2,3-dihydroinden-1-one
  • CAT. No.D040027
  • CAS. No.13336-32-8
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Custom Synthesis
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4,7-Dimethoxy-1-indanone
4,7-Dimethoxy-1-indanone
  • CAT. No.D040028
  • CAS. No. 52428-09-8
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Custom Synthesis
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5,7-Dimethoxyindan-1-one
5,7-Dimethoxyindan-1-one
  • CAT. No.D040029
  • CAS. No. 880-87-5
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Custom Synthesis
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6,7-Dimethoxyindan-1-one
6,7-Dimethoxyindan-1-one
  • CAT. No.D040030
  • CAS. No.57441-74-4
  • Mol. F.C11H12O3
  • Mol. W.192.21 g/mol
  • Stock Status:Custom Synthesis
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Donepezil-4-hydroxy
Donepezil-4-hydroxy
  • CAT. No.D040031
  • CAS. No.197010-22-3
  • Mol. F.C24H29NO4
  • Mol. W.395.49 g/mol
  • Stock Status:Custom Synthesis
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Donepezil impurity C
Donepezil impurity C
  • CAT. No.D040032
  • CAS. No.NA
  • Mol. F.C31H35NO3
  • Mol. W.469.61 g/mol
  • Stock Status:Custom Synthesis
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5,6-Dimethyl-1-indanone
5,6-Dimethyl-1-indanone
  • CAT. No.D040033
  • CAS. No.16440-97-4
  • Mol. F.C11H12O
  • Mol. W.160.21 g/mol
  • Stock Status:Custom Synthesis
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2-Chloro-1-(2-thienyl)ethanone
2-Chloro-1-(2-thienyl)ethanone
  • CAT. No.D040034
  • CAS. No.29683-77-0
  • Mol. F.C6H5ClOS
  • Mol. W.160.62 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Alkene Pyridine N-oxide
Donepezil Alkene Pyridine N-oxide
  • CAT. No.D040036
  • CAS. No.2452407-68-8
  • Mol. F.C17H15NO4
  • Mol. W.299.32 g/mol
  • Stock Status:Instock
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Donepezil Impurity 13
Donepezil Impurity 13
  • CAT. No.D040037
  • CAS. No.608511-44-0
  • Mol. F.C24H27NO3
  • Mol. W.377.48 g/mol
  • Stock Status:Instock
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2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one
2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one
  • CAT. No.D040038
  • CAS. No.896134-06-8
  • Mol. F.C17H15NO4
  • Mol. W.297.31 g/mol
  • Stock Status:Instock
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Donepezil Dihydro Impurity
Donepezil Dihydro Impurity
  • CAT. No.D040039
  • CAS. No.120012-04-6
  • Mol. F.C24H31NO3
  • Mol. W.381.52 g/mol
  • Stock Status:Instock
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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-yl)methylene-1,2,3,4-tetrahydropyridine
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-yl)methylene-1,2,3,4-tetrahydropyridine
  • CAT. No.D040040
  • CAS. No.1020661-51-1
  • Mol. F.C24H25NO3
  • Mol. W.375.46 g/mol
  • Stock Status:Instock
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Donepezil Impurity E Bromide Salt
Donepezil Impurity E Bromide Salt
  • CAT. No.D040041
  • CAS. No.231283-82-2
  • Mol. F.C24H24BrNO3
  • Mol. W.454.36 g/mol
  • Stock Status:Instock
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Dehydro Donepezil(E/Z mixture)
Dehydro Donepezil(E/Z mixture)
  • CAT. No.D040042
  • CAS. No.120014-07-5
  • Mol. F.C24H27NO3
  • Mol. W.377.49 g/mol
  • Stock Status:Custom Synthesis
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Donepezil EP Impurity A
Donepezil EP Impurity A
  • CAT. No.D040043
  • CAS. No.120014-30-4
  • Mol. F.C17H23NO3
  • Mol. W.289.37 g/mol
  • Stock Status:Instock
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Donepezil EP Impurity E
Donepezil EP Impurity E
  • CAT. No.D040044
  • CAS. No.231283-82-2
  • Mol. F.C24H24BrNO3
  • Mol. W.454.36 g/mol
  • Stock Status:Custom Synthesis
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Donepezil EP Impurity G Hydrochloride
Donepezil EP Impurity G Hydrochloride
  • CAT. No.D040045
  • CAS. No.NA
  • Mol. F.C24H27NO3.HCl
  • Mol. W.413.94 g/mol
  • Stock Status:Limited Stock
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Hydroxy Donepezil (Mixture of diastereomers)
Hydroxy Donepezil (Mixture of diastereomers)
  • CAT. No.D040046
  • CAS. No.197010-20-1
  • Mol. F.C24H29NO4
  • Mol. W.395.50 g/mol
  • Stock Status:Instock
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Donepezil Pyridine Dehydro Impurity
Donepezil Pyridine Dehydro Impurity
  • CAT. No.D040047
  • CAS. No.4803-74-1
  • Mol. F.C17H15NO3
  • Mol. W.281.31 g/mol
  • Stock Status:Custom Synthesis
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Donepezil EP Impurity C
Donepezil EP Impurity C
  • CAT. No.D040048
  • CAS. No.2452407-76-8
  • Mol. F.C24H29NO4
  • Mol. W.395.49 g/mol
  • Stock Status:Limited Stock
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5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane hydrochloride
5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane hydrochloride
  • CAT. No.D040049
  • CAS. No.1034439-43-4
  • Mol. F.C17H25NO2.HCl
  • Mol. W.311.85 g/mol
  • Stock Status:Custom Synthesis
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Donepezil deoxy impurity
Donepezil deoxy impurity
  • CAT. No.D040050
  • CAS. No.844694-84-4
  • Mol. F.C24H31NO2
  • Mol. W.365.51 g/mol
  • Stock Status:Custom Synthesis
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5,6-dimethoxy-2-(1,2,3,6-tetrahydropyridin-4ylmethyl)-2,3-dihydro-1H-inden-1ol
5,6-dimethoxy-2-(1,2,3,6-tetrahydropyridin-4ylmethyl)-2,3-dihydro-1H-inden-1ol
  • CAT. No.D040051
  • CAS. No.NA
  • Mol. F.C17H23NO3
  • Mol. W.289.37 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity G Hydrochloride
Donepezil Impurity G Hydrochloride
  • CAT. No.D040052
  • CAS. No.NA
  • Mol. F.C24H27NO3.HCl
  • Mol. W.413.94 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 18
Donepezil Impurity 18
  • CAT. No.D040053
  • CAS. No.110406-97-8
  • Mol. F.C11H15ClO2
  • Mol. W.214.69 g/mol
  • Stock Status:Custom Synthesis
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alpha-(2-chloroethyl)-3,4-dimethoxybenzenemethanol
alpha-(2-chloroethyl)-3,4-dimethoxybenzenemethanol
  • CAT. No.D040054
  • CAS. No.NA
  • Mol. F.C11H15ClO3
  • Mol. W.23.69 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 2
Donepezil Impurity 2
  • CAT. No.D040055
  • CAS. No.5888-52-8
  • Mol. F.C11H16O2
  • Mol. W.180.24 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 3
Donepezil Impurity 3
  • CAT. No.D040056
  • CAS. No.104397-78-6
  • Mol. F.C11H14O4
  • Mol. W.210.23 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 21
Donepezil Impurity 21
  • CAT. No.D040057
  • CAS. No.4693-38-3
  • Mol. F.C11H13ClO3
  • Mol. W.228.67 g/mol
  • Stock Status:Custom Synthesis
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5,6-dimethoxy-2-((6-methylpyridin-2-yl)methylene)-2,3-dihydro-1H-inden-1-one
5,6-dimethoxy-2-((6-methylpyridin-2-yl)methylene)-2,3-dihydro-1H-inden-1-one
  • CAT. No.D040058
  • CAS. No.NA
  • Mol. F.C18H17NO3
  • Mol. W.295.33 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Donepezil EP Impurity A
N-Nitroso Donepezil EP Impurity A
  • CAT. No.D040059
  • CAS. No.NA
  • Mol. F.C17H22N2O4
  • Mol. W.318.37 g/mol
  • Stock Status:Instock
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Donepezil O-Benzyl Enol Ether Hydrochloride
Donepezil O-Benzyl Enol Ether Hydrochloride
  • CAT. No.D040060
  • CAS. No.NA
  • Mol. F.C31H35NO3.HCl
  • Mol. W.506.08 g/mol
  • Stock Status:Instock
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Donepezil Pyridine N-Oxide
Donepezil Pyridine N-Oxide
  • CAT. No.D040063
  • CAS. No.896134-07-9
  • Mol. F.C17H17NO4
  • Mol. W.299.32 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Hydrochloride Form-I
Donepezil Hydrochloride Form-I
  • CAT. No.D040064
  • CAS. No.120011-70-3
  • Mol. F.C24H30ClNO3
  • Mol. W.415.95 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 27
Donepezil Impurity 27
  • CAT. No.D040065
  • CAS. No.923571-15-7
  • Mol. F.C17H15NO4
  • Mol. W.297.31 g/mol
  • Stock Status:Custom Synthesis
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(R)-Donepezil
(R)-Donepezil
  • CAT. No.D040066
  • CAS. No.142698-19-9
  • Mol. F.C24H29NO3
  • Mol. W.379.49 g/mol
  • Stock Status:Custom Synthesis
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Donepezil Impurity 4
Donepezil Impurity 4
  • CAT. No.D040067
  • CAS. No.329010-67-5
  • Mol. F.C24H29NO4
  • Mol. W.395.50 g/mol
  • Stock Status:Instock
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Donepezil Impurity 5
Donepezil Impurity 5
  • CAT. No.D040068
  • CAS. No.1180668-03-4
  • Mol. F.C24H29NO4
  • Mol. W.395.49 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

6-O-Desmethyl Donepezil Hydrochloride
6-O-Desmethyl Donepezil Hydrochloride
  • CAT. No.D040061
  • CAS. No.852285-82-6
  • Mol. F.C23H28ClNO3
  • Mol. W.401.93 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Donepezil-d4 Hydrochloride
Donepezil-d4 Hydrochloride
  • CAT. No.D040016
  • CAS. No.1219798-88-5
  • Mol. F.C24H25D4NO3.HCl
  • Mol. W.419.98 g/mol
  • Stock Status:Limited Stock
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Donepezil-D7 Hydrochloride
Donepezil-D7 Hydrochloride
  • CAT. No.D040035
  • CAS. No.1261394-20-0
  • Mol. F.C24H23D7ClNO3
  • Mol. W.423.00 g/mol
  • Stock Status:Instock
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6-O-Desmethyl Donepezil Hydrochloride -D5
6-O-Desmethyl Donepezil Hydrochloride -D5
  • CAT. No.D040062
  • CAS. No.NA
  • Mol. F.C23H23D5ClNO3
  • Mol. W.406.96 g/mol
  • Stock Status:Custom Synthesis
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