Binimetinib

Binimetinib is a selective MEK1/2 inhibitor used in combination with encorafenib for the treatment of BRAF-mutant melanoma. Simson Pharma's Binimetinib reference standard and impurities support stability-indicating method development for this targeted combination oncology therapy.

Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) supply high-quality Binimetinib Reference Standards, pharmacopoeial reference materials, and its related impurities to pharmaceutical manufacturers, CROs, analytical laboratories, universities, and regulatory organizations worldwide. To service the Europe and America market efficiently, Simson Pharma Limited has set up Simson Pharma Global Ltd. in United Kingdom and Simson Pharma Global LLC in USA respectively.

Pharmaceutical Reference Standards / Impurity Standards

Binimetinib
Binimetinib
  • CAT. No.B1270000
  • CAS. No.606143-89-9
  • Mol. F.C17H15BrF2N4O3
  • Mol. W.441.20 g/mol
  • Stock Status:Instock
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N-desmethyl Binimetinib
N-desmethyl Binimetinib
  • CAT. No.B1270003
  • CAS. No.NA
  • Mol. F.C16H13BrF2N4O3
  • Mol. W.427.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Acid Impurity
Binimetinib Acid Impurity
  • CAT. No.B1270004
  • CAS. No.1415564-99-6
  • Mol. F.C15H10BrF2N3O2
  • Mol. W.382.16 g/mol
  • Stock Status:Instock
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Binimetinib Des Ethanediol Impurity
Binimetinib Des Ethanediol Impurity
  • CAT. No.B1270005
  • CAS. No.NA
  • Mol. F.C15H11BrF2N4O
  • Mol. W.381.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Methyl Ester
Binimetinib Methyl Ester
  • CAT. No.B1270006
  • CAS. No.NA
  • Mol. F.C16H12BrF2N3O2
  • Mol. W.396.19 g/mol
  • Stock Status:Instock
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Binimetinib Impurity 20
Binimetinib Impurity 20
  • CAT. No.B1270007
  • CAS. No.NA
  • Mol. F.C15H11BrF2N4O2
  • Mol. W.397.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib N-Oxide
Binimetinib N-Oxide
  • CAT. No.B1270008
  • CAS. No.NA
  • Mol. F.C17H14BrF2N4O4
  • Mol. W.456.22 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Dimer Impurity
Binimetinib Dimer Impurity
  • CAT. No.B1270009
  • CAS. No.NA
  • Mol. F.C23H17Br2F3N4O3
  • Mol. W.614.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Ethyleneglycol Ester
Binimetinib Ethyleneglycol Ester
  • CAT. No.B1270010
  • CAS. No.NA
  • Mol. F.C17H15BrF2N4O3
  • Mol. W.441.23 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 2
Binimetinib Impurity 2
  • CAT. No.B1270011
  • CAS. No.391212-29-6
  • Mol. F.C4H9NO2
  • Mol. W.103.12 g/mol
  • Stock Status:Instock
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Binimetinib Impurity 1
Binimetinib Impurity 1
  • CAT. No.B1270012
  • CAS. No.284030-58-6
  • Mol. F.C8H6F2N2O4
  • Mol. W.232.14 g/mol
  • Stock Status:Instock
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Binimetinib Cyclized impurity
Binimetinib Cyclized impurity
  • CAT. No.B1270013
  • CAS. No.NA
  • Mol. F.C21H23BrF2N4O4
  • Mol. W.513.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 11
Binimetinib Impurity 11
  • CAT. No.B1270016
  • CAS. No.391212-30-9
  • Mol. F.C12H11NO4
  • Mol. W.233.22 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Impurity
Binimetinib Des Bromo Impurity
  • CAT. No.B1270017
  • CAS. No.NA
  • Mol. F.C17H16F2N4O3
  • Mol. W.362.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Acid Impurity
Binimetinib Des Bromo Acid Impurity
  • CAT. No.B1270018
  • CAS. No.2649854-87-3
  • Mol. F.C15H11F2N3O2
  • Mol. W.303.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Des Bromo Vinyloxy Impurity
Binimetinib Des Bromo Vinyloxy Impurity
  • CAT. No.B1270019
  • CAS. No.2649854-88-4
  • Mol. F.C19H18F2N4O3
  • Mol. W.388.37 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Ethyl Ether Impurity
Binimetinib Ethyl Ether Impurity
  • CAT. No.B1270020
  • CAS. No.NA
  • Mol. F.C19H19BrF2N4O3
  • Mol. W.469.28 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 10
Binimetinib Impurity 10
  • CAT. No.B1270021
  • CAS. No.2509103-99-3
  • Mol. F.C17H14BrF2N3O2
  • Mol. W.410.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 16
Binimetinib Impurity 16
  • CAT. No.B1270022
  • CAS. No.NA
  • Mol. F.C19H17BrF2N4O4
  • Mol. W.483.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 17
Binimetinib Impurity 17
  • CAT. No.B1270023
  • CAS. No.NA
  • Mol. F.C19H17BrF2N4O3
  • Mol. W.467.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 18
Binimetinib Impurity 18
  • CAT. No.B1270024
  • CAS. No.918321-31-0
  • Mol. F.C7H6FN3O4
  • Mol. W.215.14 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 19
Binimetinib Impurity 19
  • CAT. No.B1270025
  • CAS. No.NA
  • Mol. F.C7H4F2N2O4
  • Mol. W.218.11 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Dibromo Impurity
Binimetinib Dibromo Impurity
  • CAT. No.B1270027
  • CAS. No.NA
  • Mol. F.C17H15Br2FN4O3
  • Mol. W.502.13 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Binimetinib
N-Nitroso Binimetinib
  • CAT. No.B1270028
  • CAS. No.NA
  • Mol. F.C17H14BrF2N5O4
  • Mol. W.470.22 g/mol
  • Stock Status:Instock
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N-Nitroso N-Desmethyl Binimetinib
N-Nitroso N-Desmethyl Binimetinib
  • CAT. No.B1270029
  • CAS. No.NA
  • Mol. F.C16H12BrF2N5O4
  • Mol. W.456.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Acid Nitroso Impurity
Binimetinib Acid Nitroso Impurity
  • CAT. No.B1270030
  • CAS. No.NA
  • Mol. F.C15H9BrF2N4O3
  • Mol. W.411.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Nitroso Amide Impurity
Binimetinib Nitroso Amide Impurity
  • CAT. No.B1270031
  • CAS. No.NA
  • Mol. F.C21H22BrF2N5O4
  • Mol. W.526.30 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Binimetinib Impurity 1
N-Nitroso Binimetinib Impurity 1
  • CAT. No.B1270032
  • CAS. No.NA
  • Mol. F.C16H13BrF2N6O4
  • Mol. W.471.21 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 3
Binimetinib Impurity 3
  • CAT. No.B1270033
  • CAS. No.NA
  • Mol. F.C19H16BrF2N5O4
  • Mol. W.496.26 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 4
Binimetinib Impurity 4
  • CAT. No.B1270034
  • CAS. No.1415559-89-5
  • Mol. F.C16H13F2N3O2
  • Mol. W.317.29 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Des Ethanediol Impurity
N-Nitroso Des Ethanediol Impurity
  • CAT. No.B1270035
  • CAS. No.NA
  • Mol. F.C15H10BrF2N5O2
  • Mol. W.410.17 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Amide Impurity
Binimetinib Amide Impurity
  • CAT. No.B1270036
  • CAS. No.1604812-70-5
  • Mol. F.C21H23BrF2N4O3
  • Mol. W.497.33 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 5
Binimetinib Impurity 5
  • CAT. No.B1270037
  • CAS. No.2851526-49-1
  • Mol. F.C17H14BrF2N3O3
  • Mol. W.426.20 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Impurity 6
Binimetinib Impurity 6
  • CAT. No.B1270038
  • CAS. No.606143-94-6
  • Mol. F.C14H11F2N3O4
  • Mol. W.323.25 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

N-Desmethyl Binimetinib Hydrochloride
N-Desmethyl Binimetinib Hydrochloride
  • CAT. No.B1270014
  • CAS. No.NA
  • Mol. F.C16H14BrClF2N4O3
  • Mol. W.463.66 g/mol
  • Stock Status:Custom Synthesis
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Binimetinib Glucuronide
Binimetinib Glucuronide
  • CAT. No.B1270015
  • CAS. No.NA
  • Mol. F.C23H23BrF2N4O9
  • Mol. W.617.36 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Binimetinib 13C2-D4
Binimetinib 13C2-D4
  • CAT. No.B1270026
  • CAS. No.NA
  • Mol. F.C1513C2H11D4BrF2N4O3
  • Mol. W.447.24 g/mol
  • Stock Status:Instock
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