Aprepitant

Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist that blocks substance P-mediated emesis signalling, used in combination antiemetic regimens to prevent chemotherapy-induced nausea and vomiting. Simson Pharma's Aprepitant reference standard and impurities support stability-indicating method development for this supportive-oncology therapy.

Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) supply high-quality Aprepitant Reference Standards, pharmacopoeial reference materials, and its related impurities to pharmaceutical manufacturers, CROs, analytical laboratories, universities, and regulatory organizations worldwide. To service the Europe and America market efficiently, Simson Pharma Limited has set up Simson Pharma Global Ltd. in United Kingdom and Simson Pharma Global LLC in USA respectively.

Pharmaceutical Reference Standards / Impurity Standards

Aprepitant
Aprepitant
  • CAT. No.A610000
  • CAS. No.170729-80-3
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Instock
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Aprepitant Form II
Aprepitant Form II
  • CAT. No.A610000B
  • CAS. No.170729-80-3
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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(S)-3`,5`-Bis(trifluoromethyl)-1-phenethanol
(S)-3`,5`-Bis(trifluoromethyl)-1-phenethanol
  • CAT. No.A610001
  • CAS. No.225920-05-8
  • Mol. F.C10H8F6O
  • Mol. W.258.16 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant USP Related Compound A
Aprepitant USP Related Compound A
  • CAT. No.A610002
  • CAS. No.1148113-53-4
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Instock
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Aprepitant M2 Metabolite (1S, 2R, 3S)-Isomer
Aprepitant M2 Metabolite (1S, 2R, 3S)-Isomer
  • CAT. No.A610003
  • CAS. No.170729-79-0
  • Mol. F.C20H18F7NO2
  • Mol. W.437.35 g/mol
  • Stock Status:Custom Synthesis
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(2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
(2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
  • CAT. No.A610003A
  • CAS. No.2475188-00-0
  • Mol. F.C20H19F7NO2Cl
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant (R,S,S)-Isomer
Aprepitant (R,S,S)-Isomer
  • CAT. No.A610004
  • CAS. No.172822-28-5
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant EP Impurity A
Aprepitant EP Impurity A
  • CAT. No.A610006
  • CAS. No.170729-76-7
  • Mol. F.C23H22F6N4O3
  • Mol. W.516.44 g/mol
  • Stock Status:Instock
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Defluoro Aprepitant Hydrochloride
Defluoro Aprepitant Hydrochloride
  • CAT. No.A610006B
  • CAS. No.NA
  • Mol. F.C23H22F6N4O3.HCl
  • Mol. W.552.90 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Related Compound B
Aprepitant Related Compound B
  • CAT. No.A610007
  • CAS. No.172822-29-6
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Limited Stock
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Aprepitant RRS Isomer Hydrochloride
Aprepitant RRS Isomer Hydrochloride
  • CAT. No.A610008
  • CAS. No.171482-05-6
  • Mol. F.C20H19F7NO2Cl
  • Mol. W.473.80 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant EP Impurity B
Aprepitant EP Impurity B
  • CAT. No.A610009
  • CAS. No.2348441-62-1
  • Mol. F.C29H25F7N4O3
  • Mol. W.610.52 g/mol
  • Stock Status:Limited Stock
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Aprepitant EP Impurity C
Aprepitant EP Impurity C
  • CAT. No.A610010
  • CAS. No.2348441-63-2
  • Mol. F.C29H25F7N4O3
  • Mol. W.610.52 g/mol
  • Stock Status:Limited Stock
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Aprepitant (S,R,S)-Isomer
Aprepitant (S,R,S)-Isomer
  • CAT. No.A610011
  • CAS. No.170902-81-5
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Instock
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5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
  • CAT. No.A610012
  • CAS. No.221350-96-5
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant (S,R,R)-Isomer
Aprepitant (S,R,R)-Isomer
  • CAT. No.A610013
  • CAS. No.1242175-34-3
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Instock
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Aprepitant (S,S,S)-Isomer
Aprepitant (S,S,S)-Isomer
  • CAT. No.A610014
  • CAS. No.1242175-40-1
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Open-Ring Methyl Ester Impurity
Aprepitant Open-Ring Methyl Ester Impurity
  • CAT. No.A610015
  • CAS. No.219821-37-1
  • Mol. F.C24H25F7N4O4
  • Mol. W.566.47 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity C Hydrochloride
Aprepitant Impurity C Hydrochloride
  • CAT. No.A610017
  • CAS. No.NA
  • Mol. F.C29H25F7N4O3.HCl
  • Mol. W.646.98 g/mol
  • Stock Status:Custom Synthesis
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(Z)-methyl 2-(1-amino-2-((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazinecarboxylate
(Z)-methyl 2-(1-amino-2-((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazinecarboxylate
  • CAT. No.A610018
  • CAS. No.NA
  • Mol. F.C24H25F7N4O4
  • Mol. W.566.47 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant N-Oxide
Aprepitant N-Oxide
  • CAT. No.A610019
  • CAS. No.172673-23-3
  • Mol. F.C23H21F7N4O4
  • Mol. W.550.43 g/mol
  • Stock Status:Instock
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Aprepitant Impurity 19
Aprepitant Impurity 19
  • CAT. No.A610020
  • CAS. No.200000-59-5
  • Mol. F.C20H18F7NO2.C7H8O3S
  • Mol. W.609.55 g/mol
  • Stock Status:Instock
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Aprepitant Impurity 4
Aprepitant Impurity 4
  • CAT. No.A610021
  • CAS. No.380499-07-0
  • Mol. F.C20H16F7NO2
  • Mol. W.435.34 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Diastereomer
Aprepitant Diastereomer
  • CAT. No.A610022
  • CAS. No.NA
  • Mol. F.C21H19F6NO3
  • Mol. W.447.37 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1R,2S,3R)-Isomer Hydrochloride
Aprepitant M2 Metabolite (1R,2S,3R)-Isomer Hydrochloride
  • CAT. No.A610023
  • CAS. No.2475187-95-0
  • Mol. F.C20H19ClF7NO2
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1R,2R,3R)-Isomer Hydrochloride
Aprepitant M2 Metabolite (1R,2R,3R)-Isomer Hydrochloride
  • CAT. No.A610024
  • CAS. No.1447693-83-5
  • Mol. F.C20H19ClF7NO2
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride
Aprepitant M2 Metabolite (1S,2R,3R)-Isomer Hydrochloride
  • CAT. No.A610025
  • CAS. No.1333998-21-2
  • Mol. F.C20H19F7NO2Cl
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1R,2S,3S)-Isomer Hydrochloride
Aprepitant M2 Metabolite (1R,2S,3S)-Isomer Hydrochloride
  • CAT. No.A610026
  • CAS. No.1333998-27-8
  • Mol. F.C20H19F7NO2Cl
  • Mol. W.473.81 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1R,2R,3S)-Isomer
Aprepitant M2 Metabolite (1R,2R,3S)-Isomer
  • CAT. No.A610027
  • CAS. No.171338-27-5
  • Mol. F.C20H18F7NO2
  • Mol. W.437.40 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite (1S,2R,3R)-Isomer
Aprepitant M2 Metabolite (1S,2R,3R)-Isomer
  • CAT. No.A610030
  • CAS. No.1242175-36-5
  • Mol. F.C20H18F7NO2
  • Mol. W.437.35 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 2
Aprepitant Impurity 2
  • CAT. No.A610031
  • CAS. No.171338-33-3
  • Mol. F.C20H19F6NO2
  • Mol. W.419.36 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant (R,S,R)-Isomer
Aprepitant (R,S,R)-Isomer
  • CAT. No.A610033
  • CAS. No.1185502-97-9
  • Mol. F.C23H21F7N4O3
  • Mol. W.534.43 g/mol
  • Stock Status:Custom Synthesis
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2-(R)-(1-(R)-(3,5-bis-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl morpholine oxalate
2-(R)-(1-(R)-(3,5-bis-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl morpholine oxalate
  • CAT. No.A610035
  • CAS. No.NA
  • Mol. F.C22H20F7NO6
  • Mol. W.527.39 g/mol
  • Stock Status:Custom Synthesis
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2-(R)-(1-(R)-(3,5-bis-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(N-methylcarboxy acetamidrazono)morpholine
2-(R)-(1-(R)-(3,5-bis-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(N-methylcarboxy acetamidrazono)morpholine
  • CAT. No.A610036
  • CAS. No.NA
  • Mol. F.C24H25F7N4O4
  • Mol. W.566.47 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 12
Aprepitant Impurity 12
  • CAT. No.A610037
  • CAS. No.NA
  • Mol. F.C5H11N3O3
  • Mol. W.161.16 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 3
Aprepitant Impurity 3
  • CAT. No.A610038
  • CAS. No.287930-75-0
  • Mol. F.C21H19F6NO3
  • Mol. W.447.37 g/mol
  • Stock Status:Instock
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Fosaprepitant Impurity 11
Fosaprepitant Impurity 11
  • CAT. No.A610039
  • CAS. No.2377328-01-1
  • Mol. F.C27H24F7NO2
  • Mol. W.527.47 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Nitroso Impurity 1
Aprepitant Nitroso Impurity 1
  • CAT. No.A610040
  • CAS. No.NA
  • Mol. F.C20H17F7N2O3
  • Mol. W.466.35 g/mol
  • Stock Status:Instock
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Aprepitant Impurity 16
Aprepitant Impurity 16
  • CAT. No.A610041
  • CAS. No.1651828-04-4
  • Mol. F.C27H24F7NO3
  • Mol. W.543.47 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Nitroso Impurity 2
Aprepitant Nitroso Impurity 2
  • CAT. No.A610042
  • CAS. No.NA
  • Mol. F.C20H17F7N2O3
  • Mol. W.466.35 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 15
Aprepitant Impurity 15
  • CAT. No.A610043
  • CAS. No.127852-28-2
  • Mol. F.C10H8F6O
  • Mol. W.258.16 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 5
Aprepitant Impurity 5
  • CAT. No.A610045
  • CAS. No.502537-39-5
  • Mol. F.C20H20F7NO3
  • Mol. W.455.37 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 6
Aprepitant Impurity 6
  • CAT. No.A610046
  • CAS. No.NA
  • Mol. F.C29H30F7NO3
  • Mol. W.573.54 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 7
Aprepitant Impurity 7
  • CAT. No.A610047
  • CAS. No.NA
  • Mol. F.C16H11F7O
  • Mol. W.352.25 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant M2 Metabolite(1R,2R,3R)-Isomer
Aprepitant M2 Metabolite(1R,2R,3R)-Isomer
  • CAT. No.A610048
  • CAS. No.380499-06-9 (R isomer)
  • Mol. F.C20H18F7NO2
  • Mol. W.437.40 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 9
Aprepitant Impurity 9
  • CAT. No.A610049
  • CAS. No.398-23-2
  • Mol. F.C12H8F2
  • Mol. W.190.19 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 13
Aprepitant Impurity 13
  • CAT. No.A610050
  • CAS. No.NA
  • Mol. F.C27H22F7NO2
  • Mol. W.525.46 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 14
Aprepitant Impurity 14
  • CAT. No.A610051
  • CAS. No.NA
  • Mol. F.C26H20F5NO2.2HF
  • Mol. W.513.45 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant Impurity 21
Aprepitant Impurity 21
  • CAT. No.A610052
  • CAS. No.NA
  • Mol. F.C26H22F7NO2 .2HF
  • Mol. W.553.46 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Aprepitant L-829615 Metabolite
Aprepitant L-829615 Metabolite
  • CAT. No.A610028
  • CAS. No.NA
  • Mol. F.C20H15F7O5
  • Mol. W.468.32 g/mol
  • Stock Status:Custom Synthesis
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Aprepitant L-829617 Metabolite
Aprepitant L-829617 Metabolite
  • CAT. No.A610029
  • CAS. No.NA
  • Mol. F.C20H17F7O5
  • Mol. W.470.33 g/mol
  • Stock Status:Custom Synthesis
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N-dealkylated carbonyl aprepitant (mixture of diasteroemers)
N-dealkylated carbonyl aprepitant (mixture of diasteroemers)
  • CAT. No.A610044
  • CAS. No.NA
  • Mol. F.C20H16F7NO3
  • Mol. W.451.33 g/mol
  • Stock Status:Custom Synthesis
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Isotope Labelled Compounds

Aprepitant D4
Aprepitant D4
  • CAT. No.A610005
  • CAS. No.1133387-60-6
  • Mol. F.C23H17D4F7N4O3
  • Mol. W.538.46 g/mol
  • Stock Status:Instock
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rac-Aprepitant-D4
rac-Aprepitant-D4
  • CAT. No.A610034
  • CAS. No.NA
  • Mol. F.C23H17D4F7N4O3
  • Mol. W.538.50 g/mol
  • Stock Status:Custom Synthesis
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