Alvimopan

Alvimopan is a peripherally restricted mu-opioid receptor antagonist that accelerates gastrointestinal recovery after bowel resection surgery by blocking opioid-mediated motility suppression without crossing into the central nervous system. Simson Pharma's Alvimopan reference standard and impurities support stability-indicating testing for this perioperative GI therapy.

Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) supply high-quality Alvimopan Reference Standards, pharmacopoeial reference materials, and its related impurities to pharmaceutical manufacturers, CROs, analytical laboratories, universities, and regulatory organizations worldwide. To service the Europe and America market efficiently, Simson Pharma Limited has set up Simson Pharma Global Ltd. in United Kingdom and Simson Pharma Global LLC in USA respectively.

Pharmaceutical Reference Standards / Impurity Standards

Alvimopan
Alvimopan Dihydrate
2-(2-benzylacryamido)aceticacid
Alvimopan Impurity 27
2-((2R)-2-benzyl-3-((3R)-4-(3-hydroxyphenyl)-3-methylpiperidin-1-yl)propanamido)acetic acid
(S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid
Ethyl 2-((S)-2-benzyl-3-((3R,4R)-4-(-3-hydroxyphenyl)-3,4-dimethylpiperidin-1yl)propanamido)acetate hydrochloride
Alvimopan Isomer(2R,3S,4S)
2-((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperdin-1-yl)propanamido)acetic acid
(2S,3S,4S)-Alvimopan
Alvimopan Impurity 19
(3R,4R)-3,4-dimethyl piperidin-4-yl)phenol
Alvimopan Impurity 18
2-((R)-2-benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3.4-dimethylpiperidin-1 yl)propanamido)acetic acid hydrate
Alvimopan Impurity 20
Alvimopan Impurity 21
Alvimopan Impurity 22
Alvimopan Impurity 23
Alvimopan Impurity 24
Alvimopan Impurity 25
Alvimopan Impurity 28
Alvimopan Impurity 14
Alvimopan DMP Ester Impurity
Alvimopan Desmethyl Impurity
Alvimopan Impurity 1
Alvimopan N-Nitroso impurity 1

Metabolites

Alvimopan Metabolite
Alvimopan Acyl Glucuronide
Alvimophan metabolite (ADL08-0011)

Isotope Labelled Compounds

Alvimopan-D5
Alvimopan-D5 desglycine Metabolite
Alvimopan-d7
Alvimopan metabolite D7 (ADL08-0011), hydrochloride