Abemaciclib

Abemaciclib is an orally administered selective CDK4/6 inhibitor that arrests the cell cycle at the G1-to-S transition in hormone receptor-positive breast cancer cells, typically used in combination with endocrine therapy. As a targeted oncology agent, precise impurity and degradation profiling is essential for both originator and generic manufacturers. Simson Pharma offers an Abemaciclib reference standard and related impurities to support this analytical demand.

Simson Pharma Global Ltd. (UK) and Simson Pharma Global LLC (USA) supply high-quality Abemaciclib Reference Standards, pharmacopoeial reference materials, and its related impurities to pharmaceutical manufacturers, CROs, analytical laboratories, universities, and regulatory organizations worldwide. To service the Europe and America market efficiently, Simson Pharma Limited has set up Simson Pharma Global Ltd. in United Kingdom and Simson Pharma Global LLC in USA respectively.

Pharmaceutical Reference Standards / Impurity Standards

Abemaciclib
Abemaciclib
  • CAT. No.A1840000
  • CAS. No.1231929-97-7
  • Mol. F.C27H32F2N8
  • Mol. W.506.59 g/mol
  • Stock Status:Instock
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Abemaciclib mesylate
Abemaciclib mesylate
  • CAT. No.A1840001
  • CAS. No.1231930-82-7
  • Mol. F.C28H36F2N8O3S
  • Mol. W.602.71 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Desfluoro Pyrimidine Imidazole Impurity
Abemaciclib Desfluoro Pyrimidine Imidazole Impurity
  • CAT. No.A1840003
  • CAS. No.NA
  • Mol. F.C27H33FN8
  • Mol. W.488.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Metabolites M2
Abemaciclib Nitroso Metabolites M2
  • CAT. No.A1840005
  • CAS. No.NA
  • Mol. F.C25H27F2N9O
  • Mol. W.507.54 g/mol
  • Stock Status:Instock
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Abemaciclib Nitroso Impurity 2
Abemaciclib Nitroso Impurity 2
  • CAT. No.A1840006
  • CAS. No.NA
  • Mol. F.C10H15N5O
  • Mol. W.221.26 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Impurity 3
Abemaciclib Nitroso Impurity 3
  • CAT. No.A1840007
  • CAS. No.NA
  • Mol. F.C10H13BrN4O
  • Mol. W.285.14 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Impurity 1
Abemaciclib Nitroso Impurity 1
  • CAT. No.A1840008
  • CAS. No.NA
  • Mol. F.C27H31F2N9O
  • Mol. W.535.59 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 11
Abemaciclib Impurity 11
  • CAT. No.A1840009
  • CAS. No.1627082-92-1
  • Mol. F.C21H18F2N6O
  • Mol. W.410.40 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 12
Abemaciclib Impurity 12
  • CAT. No.A1840010
  • CAS. No.1648707-16-7
  • Mol. F.C21H20F2N6O
  • Mol. W.410.42 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 13
Abemaciclib Impurity 13
  • CAT. No.A1840011
  • CAS. No.NA
  • Mol. F.C27H32F2N8
  • Mol. W.506.59 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 14
Abemaciclib Impurity 14
  • CAT. No.A1840012
  • CAS. No.NA
  • Mol. F.C42H44F4N12
  • Mol. W.792.90 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 15
Abemaciclib Impurity 15
  • CAT. No.A1840013
  • CAS. No.NA
  • Mol. F.C46H46F4N14
  • Mol. W.871.00 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Impurity 4
Abemaciclib Nitroso Impurity 4
  • CAT. No.A1840014
  • CAS. No.NA
  • Mol. F.C28H33F2N7O
  • Mol. W.521.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 22
Abemaciclib Impurity 22
  • CAT. No.A1840016
  • CAS. No.1231930-29-2
  • Mol. F.C11H13BrF2N2
  • Mol. W.291.10 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 7
Abemaciclib Impurity 7
  • CAT. No.A1840017
  • CAS. No.1038408-36-4
  • Mol. F.C11H13BrN2
  • Mol. W.253.14 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 6
Abemaciclib Impurity 6
  • CAT. No.A1840018
  • CAS. No.1528469-78-4
  • Mol. F.C11H13FN2
  • Mol. W.192.23 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 24
Abemaciclib Impurity 24
  • CAT. No.A1840019
  • CAS. No.1178566-52-3
  • Mol. F.C15H24N4O2
  • Mol. W.292.40 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 18
Abemaciclib Impurity 18
  • CAT. No.A1840021
  • CAS. No.NA
  • Mol. F.C28H33F2N7O
  • Mol. W.521.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 17
Abemaciclib Impurity 17
  • CAT. No.A1840022
  • CAS. No.NA
  • Mol. F.C28H33F2N7O
  • Mol. W.521.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 16
Abemaciclib Impurity 16
  • CAT. No.A1840023
  • CAS. No.NA
  • Mol. F.C28H33F2N7O2
  • Mol. W.537.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 28
Abemaciclib Impurity 28
  • CAT. No.A1840024
  • CAS. No.NA
  • Mol. F.C21H18F2N6O2
  • Mol. W.424.40 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 29
Abemaciclib Impurity 29
  • CAT. No.A1840025
  • CAS. No.141838-75-7
  • Mol. F.C11H14N2
  • Mol. W.174.24 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 21
Abemaciclib Impurity 21
  • CAT. No.A1840026
  • CAS. No.2189739-28-2
  • Mol. F.C10H10BrFN2
  • Mol. W.257.10 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 30
Abemaciclib Impurity 30
  • CAT. No.A1840027
  • CAS. No.NA
  • Mol. F.C27H33FN8
  • Mol. W.488.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 31
Abemaciclib Impurity 31
  • CAT. No.A1840028
  • CAS. No.1873303-32-2
  • Mol. F.C15H14ClFN4
  • Mol. W.304.75 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 32
Abemaciclib Impurity 32
  • CAT. No.A1840029
  • CAS. No.1231930-47-4
  • Mol. F.C15H14ClFN4
  • Mol. W.304.75 g/mol
  • Stock Status:Custom Synthesis
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6-Chloro-5-fluoropyrimidin-2(1H)-one
6-Chloro-5-fluoropyrimidin-2(1H)-one
  • CAT. No.A1840030
  • CAS. No.22462-34-6
  • Mol. F.C4H2ClFN2O
  • Mol. W.148.52 g/mol
  • Stock Status:Custom Synthesis
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5-(Piperazin-1-ylmethyl)pyridin-2-amine
5-(Piperazin-1-ylmethyl)pyridin-2-amine
  • CAT. No.A1840031
  • CAS. No.1178566-47-6
  • Mol. F.C10H16N4
  • Mol. W.192.26 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Impurity 5
Abemaciclib Nitroso Impurity 5
  • CAT. No.A1840033
  • CAS. No.NA
  • Mol. F.C24H25F2N9O
  • Mol. W.493.51 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib nitroso impurity 6
Abemaciclib nitroso impurity 6
  • CAT. No.A1840034
  • CAS. No.NA
  • Mol. F.C8H5BrFN3O
  • Mol. W.258.05 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 4
Abemaciclib Impurity 4
  • CAT. No.A1840035
  • CAS. No.1231930-37-2
  • Mol. F.C17H24BFN2O2
  • Mol. W.318.19 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib nitroso impurity 7
Abemaciclib nitroso impurity 7
  • CAT. No.A1840036
  • CAS. No.NA
  • Mol. F.C8H7BFN3O3
  • Mol. W.318.19 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib nitroso impurity 8
Abemaciclib nitroso impurity 8
  • CAT. No.A1840037
  • CAS. No.NA
  • Mol. F.C12H6ClF2N5O
  • Mol. W.309.66 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib nitroso impurity 9
Abemaciclib nitroso impurity 9
  • CAT. No.A1840038
  • CAS. No.NA
  • Mol. F.C10H14N4O
  • Mol. W.206.24 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib nitroso impurity 10
Abemaciclib nitroso impurity 10
  • CAT. No.A1840039
  • CAS. No.NA
  • Mol. F.C6H13N3O
  • Mol. W.143.19 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 33
Abemaciclib Impurity 33
  • CAT. No.A1840040
  • CAS. No.NA
  • Mol. F.C11H13BrF2N2
  • Mol. W.291.14 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 34
Abemaciclib Impurity 34
  • CAT. No.A1840041
  • CAS. No.NA
  • Mol. F.C14H20BrFN2
  • Mol. W.315.22 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 35
Abemaciclib Impurity 35
  • CAT. No.A1840042
  • CAS. No.NA
  • Mol. F.C12H17BrN2O
  • Mol. W.285.18 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 36
Abemaciclib Impurity 36
  • CAT. No.A1840043
  • CAS. No.3062616-90-1
  • Mol. F.C22H24F2N4
  • Mol. W.382.45 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 5
Abemaciclib Impurity 5
  • CAT. No.A1840044
  • CAS. No.2346512-66-9
  • Mol. F.C11H14BFN2O2
  • Mol. W.236.05 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib N-Oxide Impurity 1
Abemaciclib N-Oxide Impurity 1
  • CAT. No.A1840045
  • CAS. No.NA
  • Mol. F.C27H32F2N8O
  • Mol. W.522.59 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 37
Abemaciclib Impurity 37
  • CAT. No.A1840046
  • CAS. No.NA
  • Mol. F.C15H15F2N5
  • Mol. W.303.31 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 38
Abemaciclib Impurity 38
  • CAT. No.A1840047
  • CAS. No.NA
  • Mol. F.C16H14F2N6
  • Mol. W.328.32 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 39
Abemaciclib Impurity 39
  • CAT. No.A1840048
  • CAS. No.NA
  • Mol. F.C18H15F2N7
  • Mol. W.367.36 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 40
Abemaciclib Impurity 40
  • CAT. No.A1840049
  • CAS. No.NA
  • Mol. F.C12H9F2N5
  • Mol. W.261.23 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 8
Abemaciclib Impurity 8
  • CAT. No.A1840050
  • CAS. No.NA
  • Mol. F.C26H25F3N6
  • Mol. W.478.50 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 9
Abemaciclib Impurity 9
  • CAT. No.A1840051
  • CAS. No.NA
  • Mol. F.C15H13ClF2N4
  • Mol. W.322.70 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 10
Abemaciclib Impurity 10
  • CAT. No.A1840052
  • CAS. No.NA
  • Mol. F.C30H26F4N8
  • Mol. W.574.57 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib N-Oxide Impurity 2
Abemaciclib N-Oxide Impurity 2
  • CAT. No.A1840053
  • CAS. No.NA
  • Mol. F.C27H32F2N8O
  • Mol. W.522.60 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 19
Abemaciclib Impurity 19
  • CAT. No.A1840054
  • CAS. No.NA
  • Mol. F.C20H18F2N6O
  • Mol. W.396.39 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 20
Abemaciclib Impurity 20
  • CAT. No.A1840055
  • CAS. No.1231930-25-8
  • Mol. F.C12H18BrN3
  • Mol. W.284.20 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Abemaciclib Impurity 1
N-Nitroso Abemaciclib Impurity 1
  • CAT. No.A1840056
  • CAS. No.NA
  • Mol. F.C27H32FN9O
  • Mol. W.517.61 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Abemaciclib Impurity 2
N-Nitroso Abemaciclib Impurity 2
  • CAT. No.A1840057
  • CAS. No.NA
  • Mol. F.C25H26F2N10O2
  • Mol. W.536.55 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 23
Abemaciclib Impurity 23
  • CAT. No.A1840058
  • CAS. No.NA
  • Mol. F.C13H15F2N5
  • Mol. W.279.29 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Alcohol Dimer Impurity
Abemaciclib Alcohol Dimer Impurity
  • CAT. No.A1840059
  • CAS. No.NA
  • Mol. F.C37H33F4N9O
  • Mol. W.695.71 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Desethyl Dimer Impurity
Abemaciclib Desethyl Dimer Impurity
  • CAT. No.A1840060
  • CAS. No.NA
  • Mol. F.C40H40F4N12
  • Mol. W.764.82 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Des-Ethyl Nitroso Impurity
Abemaciclib Des-Ethyl Nitroso Impurity
  • CAT. No.A1840061
  • CAS. No.NA
  • Mol. F.C27H29F2N7O
  • Mol. W.505.56 g/mol
  • Stock Status:Custom Synthesis
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N-Nitroso Abemaciclib Impurity 3
N-Nitroso Abemaciclib Impurity 3
  • CAT. No.A1840062
  • CAS. No.NA
  • Mol. F.C28H29F2N7O2
  • Mol. W.533.57 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 25
Abemaciclib Impurity 25
  • CAT. No.A1840063
  • CAS. No.NA
  • Mol. F.C27H32F2N8O2
  • Mol. W.538.59 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 26
Abemaciclib Impurity 26
  • CAT. No.A1840064
  • CAS. No.NA
  • Mol. F.C30H27F4N9
  • Mol. W.589.90 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib impurity 27
Abemaciclib impurity 27
  • CAT. No.A1840065
  • CAS. No.NA
  • Mol. F.C11H12ClFN2
  • Mol. W.226.68 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 42
Abemaciclib Impurity 42
  • CAT. No.A1840067
  • CAS. No.NA
  • Mol. F.C4H3FN2O2
  • Mol. W.130.08 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Impurity 41
Abemaciclib Impurity 41
  • CAT. No.A1840068
  • CAS. No.1231930-33-8
  • Mol. F.C11H12BrFN2
  • Mol. W.271.13 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Nitroso Impurity 11
Abemaciclib Nitroso Impurity 11
  • CAT. No.A1840069
  • CAS. No.NA
  • Mol. F.C11H14BrN3O
  • Mol. W.284.15 g/mol
  • Stock Status:Custom Synthesis
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Abemaciclib Alcohol Dimer Impurity 1
Abemaciclib Alcohol Dimer Impurity 1
  • CAT. No.A1840070
  • CAS. No.NA
  • Mol. F.C36H32F4N10O
  • Mol. W.696.70 g/mol
  • Stock Status:Custom Synthesis
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Metabolites

Abemaciclib Metabolites M2
Abemaciclib Metabolites M2
  • CAT. No.A1840002
  • CAS. No.1231930-57-6
  • Mol. F.C25H28F2N8
  • Mol. W.478.54 g/mol
  • Stock Status:Instock
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Abemaciclib Metabolite M20
Abemaciclib Metabolite M20
  • CAT. No.A1840015
  • CAS. No.2138499-06-4
  • Mol. F.C27H32F2N8O
  • Mol. W.522.59 g/mol
  • Stock Status:Instock
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Abemaciclib Metabolite M18
Abemaciclib Metabolite M18
  • CAT. No.A1840020
  • CAS. No.2704316-81-2
  • Mol. F.C25H28F2N8O
  • Mol. W.494.54 g/mol
  • Stock Status:Instock
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Isotope Labelled Compounds

Abemaciclib D8
Abemaciclib D8
  • CAT. No.A1840004
  • CAS. No.2088650-53-5
  • Mol. F.C27H24D8F2N8
  • Mol. W.514.64 g/mol
  • Stock Status:Under Synthesis
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Abemaciclib D5
Abemaciclib D5
  • CAT. No.A1840032
  • CAS. No.1809251-51-1
  • Mol. F.C27H27D5F2N8
  • Mol. W.511.63 g/mol
  • Stock Status:Custom Synthesis
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