Total structure confirmation service at Simson pharma

Introduction:

In the fast-paced pharmaceutical market involving APIs, drug products, impurities and excipients, etc the need for prompt structure elucidation is vital to the product release. Simson pharma possess the necessary infrastructure and skill set to achieve the total structure confirmation in minimal time.

Let’s explore step wise flow path for structure elucidation.

1. Development of chromatography and subsequently evolving LCMS compatible method for separation of known/unknown impurities of interest.
2. Identifying the parent ion mass of impurity.
3. Performing MS/MS (product ion scanning) for estimation of fragments generated from the structure using collision energy applied to the parent ion.
4. Performing 1D and required 2D NMR experiments to confirm the structure.
5. Generation of final report after confirmation of impurities.
6. Collection of target impurities using PREP HPLC instrument whenever required.

Lab mages

Conclusion:

The total structure confirmation of impurities needs proper infrastructure, quality talent in employees and prompt execution and delivery of final report after confirmation of impurity structure, which is being performed on regular basis at Simson pharma.